FBXO25 and ANKRD13A

Number of citations of the paper that reports this interaction (PubMedID 23940030)
41

Data Source:
BioGRID (enzymatic study)

		FBXO25	ANKRD13A
Description		F-box protein 25	ankyrin repeat domain 13A
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleolus Cytoplasm SCF Ubiquitin Ligase Complex	Cytoplasm Endosome Late Endosome Plasma Membrane Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Actin Binding Ubiquitin-protein Transferase Activity Protein Binding	Ubiquitin-modified Protein Reader Activity
	Biological Process	Protein Ubiquitination	Negative Regulation Of Receptor Internalization Negative Regulation Of Protein Localization To Endosome
Pathways
Drugs
Diseases
GWAS		Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952) Nontraumatic osteonecrosis of the femoral head ( 32701715)	Bipolar disorder ( 31043756) Metabolite levels (MHPG) ( 23319000) Systolic blood pressure ( 30578418)
Interacting Genes		83 interacting genes: ANKRD13A APLF AXL BMX BRME1 CDK5RAP2 CDK9 CENPB CHLSN CUL1 CXXC4 DAXX DCX DDX42 DEPTOR DNAJB2 DNAJC8 DYRK3 DYRK4 EGFR EID3 EIF4E2 ELK1 EPN1 FKBP3 G3BP1 GRK2 GTF2B GTF2IRD2 HIP1 HMCES HP1BP3 IL21 ILRUN ING3 IRS1 JHY KDR KRT8 LMCD1 LUC7L MAT2B NKX2-5 NSRP1 NUAK1 ODF2 ORC4 PADI4 PAK4 PCK1 PDGFRA PIP4K2C PPID PPP1R8 PRKCA PRKG2 PRR15 PRRG1 PSMD4 RABEP2 RBM8A RHBDD1 RIOK3 RPAP3 RPS10 RPS6KB2 SAMHD1 SERBP1 SKP1 STAC SYTL2 TBX5 TCEAL2 TCEANC TCP10L TMA7 TNIP2 TRUB1 TWF1 UBE2D3 UBQLN1 UBQLN2 WDSUB1	12 interacting genes: FBXO25 GRB2 LAPTM5 MFHAS1 QDPR RIPK1 RNF11 SMAD5 SMURF1 UBC VCP WBP2
Entrez ID		26260	88455
HPRD ID		16439	12458
Ensembl ID		ENSG00000147364	ENSG00000076513
Uniprot IDs		Q8TCJ0	Q3ZTS7 Q8IZ07 Q9Y5A3
PDB IDs
Enriched GO Terms of Interacting Partners?		Kinase Activity Protein Kinase Activity Protein Tyrosine Kinase Activity Nucleus Polyubiquitin Modification-dependent Protein Binding Cytosol ATP Binding Nucleotide Binding Protein Phosphorylation Phosphorylation Protein Serine/threonine Kinase Activity Apoptotic Process Atrioventricular Node Cell Fate Commitment Nucleoplasm Cell Death Programmed Cell Death Cytoplasm Protein Serine Kinase Activity His-Purkinje System Cell Differentiation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Macromolecule Metabolic Process Negative Regulation Of Signal Transduction Regulation Of Apoptotic Process Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Cardioblast Differentiation Atrioventricular Node Cell Development Bundle Of His Development Vascular Endothelial Growth Factor Binding Cellular Response To Stress Regulation Of Programmed Cell Death Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Signal Transduction Protein Metabolic Process Vascular Endothelial Growth Factor Receptor Activity Transferase Activity Proteasomal Protein Catabolic Process Cardiac Muscle Cell Fate Commitment Cardiac Ventricle Formation Negative Regulation Of Endothelial Cell Apoptotic Process Ubiquitin Ligase Complex Scaffold Activity Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Modification Process Atrial Septum Development Positive Regulation Of Natural Killer Cell Differentiation Ubiquitin-modified Protein Reader Activity ERAD Pathway Regulation Of Cell Communication Autophagosome Assembly	Ubiquitin Protein Ligase Binding Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Intracellular Signal Transduction I-SMAD Binding Protein Ubiquitination Protein Modification By Small Protein Conjugation Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Signal Transduction Post-translational Protein Modification Vacuolar Transport Regulation Of Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Ubiquitin-dependent Protein Catabolic Process Guanyl-nucleotide Exchange Factor Adaptor Activity Regulation Of Cell Communication Cytoplasm Regulation Of Signaling Mitochondrion Dihydrobiopterin Metabolic Process 6,7-dihydropteridine Reductase Activity Protein Modification Process Macromolecule Catabolic Process Modification-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Flavin Adenine Dinucleotide Catabolic Process Positive Regulation Of Intracellular Signal Transduction Induction Of Programmed Cell Death Negative Regulation Of Pre-B Cell Receptor Expression Positive Regulation Of Lysosomal Membrane Permeability Protein Targeting To Vacuole Engulfment Of Target By Autophagosome Canonical NF-kappaB Signal Transduction Regulation Of MAPK Cascade Establishment Of Protein Localization To Vacuole Positive Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Reactive Oxygen Species Metabolic Process Proteolysis Involved In Protein Catabolic Process Catabolic Process Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Response To Cytokine Stimulus Regulation Of Intracellular Signal Transduction Grb2-EGFR Complex Negative Regulation Of Fas Signaling Pathway Erythrocyte Differentiation VCP-NSFL1C Complex Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control
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