FBXO25 and ING3

Number of citations of the paper that reports this interaction (PubMedID 23940030)
41

Data Source:
BioGRID (enzymatic study)

		FBXO25	ING3
Description		F-box protein 25	inhibitor of growth family member 3
Image		No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleolus Cytoplasm SCF Ubiquitin Ligase Complex	Nucleosome Swr1 Complex Nucleus Nucleoplasm Piccolo Histone Acetyltransferase Complex NuA4 Histone Acetyltransferase Complex
	Molecular Function	Actin Binding Ubiquitin-protein Transferase Activity Protein Binding	Zinc Ion Binding Histone H4 Acetyltransferase Activity Histone H4K5 Acetyltransferase Activity Histone H4K8 Acetyltransferase Activity Histone H4K12 Acetyltransferase Activity Histone H2A Acetyltransferase Activity Metal Ion Binding Histone H4K16 Acetyltransferase Activity Histone H3K4me3 Reader Activity
	Biological Process	Protein Ubiquitination	Chromatin Organization Chromatin Remodeling Regulation Of Apoptotic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Double-strand Break Repair
Pathways			HATs acetylate histones
Drugs
Diseases
GWAS		Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952) Nontraumatic osteonecrosis of the femoral head ( 32701715)
Interacting Genes		83 interacting genes: ANKRD13A APLF AXL BMX BRME1 CDK5RAP2 CDK9 CENPB CHLSN CUL1 CXXC4 DAXX DCX DDX42 DEPTOR DNAJB2 DNAJC8 DYRK3 DYRK4 EGFR EID3 EIF4E2 ELK1 EPN1 FKBP3 G3BP1 GRK2 GTF2B GTF2IRD2 HIP1 HMCES HP1BP3 IL21 ILRUN ING3 IRS1 JHY KDR KRT8 LMCD1 LUC7L MAT2B NKX2-5 NSRP1 NUAK1 ODF2 ORC4 PADI4 PAK4 PCK1 PDGFRA PIP4K2C PPID PPP1R8 PRKCA PRKG2 PRR15 PRRG1 PSMD4 RABEP2 RBM8A RHBDD1 RIOK3 RPAP3 RPS10 RPS6KB2 SAMHD1 SERBP1 SKP1 STAC SYTL2 TBX5 TCEAL2 TCEANC TCP10L TMA7 TNIP2 TRUB1 TWF1 UBE2D3 UBQLN1 UBQLN2 WDSUB1	10 interacting genes: APP BEX5 FBXO25 FOXP2 NR1H2 NR1H3 SIVA1 TEX11 TRIM54 USHBP1
Entrez ID		26260	54556
HPRD ID		16439	06321
Ensembl ID		ENSG00000147364	ENSG00000071243
Uniprot IDs		Q8TCJ0	B7ZKQ7 Q9NXR8
PDB IDs			1X4I 7ZMX
Enriched GO Terms of Interacting Partners?		Kinase Activity Protein Kinase Activity Protein Tyrosine Kinase Activity Nucleus Polyubiquitin Modification-dependent Protein Binding Cytosol ATP Binding Nucleotide Binding Protein Phosphorylation Phosphorylation Protein Serine/threonine Kinase Activity Apoptotic Process Atrioventricular Node Cell Fate Commitment Nucleoplasm Cell Death Programmed Cell Death Cytoplasm Protein Serine Kinase Activity His-Purkinje System Cell Differentiation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Macromolecule Metabolic Process Negative Regulation Of Signal Transduction Regulation Of Apoptotic Process Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Cardioblast Differentiation Atrioventricular Node Cell Development Bundle Of His Development Vascular Endothelial Growth Factor Binding Cellular Response To Stress Regulation Of Programmed Cell Death Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Signal Transduction Protein Metabolic Process Vascular Endothelial Growth Factor Receptor Activity Transferase Activity Proteasomal Protein Catabolic Process Cardiac Muscle Cell Fate Commitment Cardiac Ventricle Formation Negative Regulation Of Endothelial Cell Apoptotic Process Ubiquitin Ligase Complex Scaffold Activity Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Modification Process Atrial Septum Development Positive Regulation Of Natural Killer Cell Differentiation Ubiquitin-modified Protein Reader Activity ERAD Pathway Regulation Of Cell Communication Autophagosome Assembly	Negative Regulation Of Type II Interferon-mediated Signaling Pathway Negative Regulation Of Pinocytosis Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Triglyceride Biosynthetic Process Regulation Of Type II Interferon-mediated Signaling Pathway Regulation Of Response To Type II Interferon Negative Regulation Of Cholesterol Storage Negative Regulation Of Macrophage Derived Foam Cell Differentiation Phosphatidylcholine Acyl-chain Remodeling Regulation Of Triglyceride Biosynthetic Process Negative Regulation Of Lipid Storage Positive Regulation Of Triglyceride Metabolic Process Positive Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Of Small Molecule Metabolic Process Positive Regulation Of Cholesterol Efflux Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Cholesterol Transport Negative Regulation Of Lipid Transport Positive Regulation Of Fatty Acid Metabolic Process Regulation Of Triglyceride Metabolic Process Regulation Of Lipid Storage Regulation Of Fatty Acid Biosynthetic Process MRNA Transcription By RNA Polymerase II Regulation Of Cholesterol Efflux Negative Regulation Of Cold-induced Thermogenesis Negative Regulation Of Response To Endoplasmic Reticulum Stress Nuclear Receptor Activity Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway MRNA Transcription Positive Regulation Of Secretion Of Lysosomal Enzymes Negative Regulation Of Secretion Of Lysosomal Enzymes CD27 Receptor Binding Meiotic Gene Conversion Putamen Development Caudate Nucleus Development Phosphatidylcholine Metabolic Process Regulation Of Endocytosis Regulation Of Cholesterol Transport Negative Regulation Of Endocytosis Regulation Of Small Molecule Metabolic Process Regulation Of MiRNA Transcription Positive Regulation Of Transport Acetylcholine Receptor Activator Activity Regulation Of MiRNA Metabolic Process Metal Ion Binding Regulation Of Proteolysis
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