FBXO25 and RIOK3

Number of citations of the paper that reports this interaction (PubMedID 23940030)
41

Data Source:
BioGRID (enzymatic study)

		FBXO25	RIOK3
Description		F-box protein 25	RIO kinase 3
Image		No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleolus Cytoplasm SCF Ubiquitin Ligase Complex	Cytoplasm Cytosol Preribosome, Small Subunit Precursor
	Molecular Function	Actin Binding Ubiquitin-protein Transferase Activity Protein Binding	Nucleotide Binding Catalytic Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Caspase Binding Protein Serine Kinase Activity
	Biological Process	Protein Ubiquitination	Immune System Process Chromosome Segregation Maturation Of SSU-rRNA Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Interferon-beta Production Negative Regulation Of MDA-5 Signaling Pathway Ribosome Biogenesis Negative Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Positive Regulation Of Innate Immune Response Defense Response To Virus Cellular Response To DsRNA Cellular Response To Virus Cellular Response To DsDNA
Pathways			Major pathway of rRNA processing in the nucleolus and cytosol
Drugs			Fostamatinib
Diseases
GWAS		Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952) Nontraumatic osteonecrosis of the femoral head ( 32701715)	Anthropometric traits ( 30166351) Anthropometric traits (multi-trait analysis) ( 30166351) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 27863252 32888494) Poultry consumption ( 32066663) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Spontaneous preterm birth without premature rupture of membranes ( 31194736) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		83 interacting genes: ANKRD13A APLF AXL BMX BRME1 CDK5RAP2 CDK9 CENPB CHLSN CUL1 CXXC4 DAXX DCX DDX42 DEPTOR DNAJB2 DNAJC8 DYRK3 DYRK4 EGFR EID3 EIF4E2 ELK1 EPN1 FKBP3 G3BP1 GRK2 GTF2B GTF2IRD2 HIP1 HMCES HP1BP3 IL21 ILRUN ING3 IRS1 JHY KDR KRT8 LMCD1 LUC7L MAT2B NKX2-5 NSRP1 NUAK1 ODF2 ORC4 PADI4 PAK4 PCK1 PDGFRA PIP4K2C PPID PPP1R8 PRKCA PRKG2 PRR15 PRRG1 PSMD4 RABEP2 RBM8A RHBDD1 RIOK3 RPAP3 RPS10 RPS6KB2 SAMHD1 SERBP1 SKP1 STAC SYTL2 TBX5 TCEAL2 TCEANC TCP10L TMA7 TNIP2 TRUB1 TWF1 UBE2D3 UBQLN1 UBQLN2 WDSUB1	9 interacting genes: BCL2L11 CASP10 CDC42 CREB3L3 FBXO25 PAK2 SMURF1 TULP3 UBC
Entrez ID		26260	8780
HPRD ID		16439	04659
Ensembl ID		ENSG00000147364	ENSG00000101782
Uniprot IDs		Q8TCJ0	B0YJ89 B4E1Q4 O14730
PDB IDs			8ZDB 8ZDC 8ZDD
Enriched GO Terms of Interacting Partners?		Kinase Activity Protein Kinase Activity Protein Tyrosine Kinase Activity Nucleus Polyubiquitin Modification-dependent Protein Binding Cytosol ATP Binding Nucleotide Binding Protein Phosphorylation Phosphorylation Protein Serine/threonine Kinase Activity Apoptotic Process Atrioventricular Node Cell Fate Commitment Nucleoplasm Cell Death Programmed Cell Death Cytoplasm Protein Serine Kinase Activity His-Purkinje System Cell Differentiation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Macromolecule Metabolic Process Negative Regulation Of Signal Transduction Regulation Of Apoptotic Process Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Cardioblast Differentiation Atrioventricular Node Cell Development Bundle Of His Development Vascular Endothelial Growth Factor Binding Cellular Response To Stress Regulation Of Programmed Cell Death Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Signal Transduction Protein Metabolic Process Vascular Endothelial Growth Factor Receptor Activity Transferase Activity Proteasomal Protein Catabolic Process Cardiac Muscle Cell Fate Commitment Cardiac Ventricle Formation Negative Regulation Of Endothelial Cell Apoptotic Process Ubiquitin Ligase Complex Scaffold Activity Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Modification Process Atrial Septum Development Positive Regulation Of Natural Killer Cell Differentiation Ubiquitin-modified Protein Reader Activity ERAD Pathway Regulation Of Cell Communication Autophagosome Assembly	Positive Regulation Of Execution Phase Of Apoptosis Execution Phase Of Apoptosis Wnt Signaling Pathway, Planar Cell Polarity Pathway Adherens Junction Organization Membrane Invagination Non-canonical Wnt Signaling Pathway Positive Regulation Of Neuron Apoptotic Process BIM-BCL-2 Complex BIM-BCL-xl Complex Engulfment Of Target By Autophagosome
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