SPEF1 and NKX2-2

		SPEF1	NKX2-2
Description		sperm flagellar 1	NK2 homeobox 2
Image			No pdb structure
GO Annotations	Cellular Component	Stress Fiber Cytoplasm Cytoskeleton Microtubule Plasma Membrane Microvillus Cilium Axoneme Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lamellipodium Filopodium Motile Cilium Cell Projection Ciliary Tip 9+2 Motile Cilium Plasma Membrane Bounded Cell Projection Axonemal Central Apparatus	Chromatin Nucleus Nucleoplasm
	Molecular Function	Actin Binding Protein Binding Microtubule Binding Cytoskeletal Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding
	Biological Process	Microtubule Bundle Formation Cilium Movement Negative Regulation Of Microtubule Depolymerization Cell Migration Cell Projection Organization Lamellipodium Assembly Filopodium Assembly Regulation Of Cytoskeleton Organization Axonemal Central Apparatus Assembly Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway	Type B Pancreatic Cell Differentiation Type B Pancreatic Cell Development Pancreatic A Cell Fate Commitment Type B Pancreatic Cell Fate Commitment Pancreatic PP Cell Fate Commitment Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Smoothened Signaling Pathway Nervous System Development Brain Development Response To Glucose Positive Regulation Of Gene Expression Oligodendrocyte Development Spinal Cord Motor Neuron Differentiation Spinal Cord Oligodendrocyte Cell Differentiation Spinal Cord Oligodendrocyte Cell Fate Specification Optic Nerve Development Central Nervous System Neuron Differentiation Cell Differentiation Neuron Differentiation Positive Regulation Of Epithelial Cell Differentiation Endocrine Pancreas Development Response To Progesterone Negative Regulation Of Neuron Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Cell Development Digestive Tract Development Neuron Fate Specification Astrocyte Differentiation Oligodendrocyte Differentiation Positive Regulation Of Oligodendrocyte Differentiation Ventral Spinal Cord Interneuron Fate Determination Neuroendocrine Cell Differentiation
Pathways			Regulation of gene expression in beta cells Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells
Drugs
Diseases
GWAS		Cognitive decline rate in late mild cognitive impairment ( 26252872) Hippocampal volume ( 29860282) Lymphocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494)	Autism spectrum disorder ( 30804558) Chronotype ( 30696823) Ewing sarcoma ( 30093639) Hyperglycemia in higher physical activity ( 30327367) Lupus nephritis in systemic lupus erythematosus ( 24925725) Refractive error ( 32231278)
Interacting Genes		8 interacting genes: CFTR CYSRT1 KIZ KRT40 KRTAP13-2 NKX2-2 PLEKHF2 ZBED1	7 interacting genes: CDK5RAP1 DLGAP4 KIZ OLIG2 RASSF2 RECQL SPEF1
Entrez ID		25876	4821
HPRD ID		09839	05213
Ensembl ID		ENSG00000101222	ENSG00000125820
Uniprot IDs		Q9Y4P9	O95096
PDB IDs		2EE7
Enriched GO Terms of Interacting Partners?		Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Ventral Spinal Cord Interneuron Fate Determination Type B Pancreatic Cell Fate Commitment Protein Autosumoylation Positive Regulation Of Anion Channel Activity Pancreatic A Cell Fate Commitment Pancreatic PP Cell Fate Commitment Keratin Filament Positive Regulation Of Monoatomic Anion Transport Spinal Cord Oligodendrocyte Cell Fate Specification Positive Regulation Of Enamel Mineralization Oligodendrocyte Cell Fate Specification Transepithelial Water Transport Spinal Cord Oligodendrocyte Cell Differentiation Intermediate Filament Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Glial Cell Fate Specification Structural Molecule Activity Bicarbonate Transmembrane Transporter Activity Early Endosome Membrane Intracellular PH Elevation Response To Ketone Amelogenesis ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Type B Pancreatic Cell Differentiation Neuron Fate Determination	Double-stranded DNA Helicase Activity DNA/DNA Annealing Activity Negative Regulation Of Protein Phosphorylation Negative Regulation Of Phosphorylation Spinal Cord Oligodendrocyte Cell Fate Specification Axonemal Central Apparatus Positive Regulation Of Translational Fidelity TRNA-2-methylthio-N(6)-dimethylallyladenosine(37) Synthase Activity Methylthiotransferase Activity TRNA Methylthiolation Negative Regulation Of Phosphate Metabolic Process Spinal Cord Oligodendrocyte Cell Differentiation Oligodendrocyte Cell Fate Specification Axonemal Central Apparatus Assembly Four-way Junction Helicase Activity Positive Regulation Of Protein Autophosphorylation Negative Regulation Of Peptidyl-serine Phosphorylation Glial Cell Fate Specification Regulation Of Neuron Differentiation
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