NKX2-2 and RASSF2

		NKX2-2	RASSF2
Description		NK2 homeobox 2	Ras association domain family member 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Chromosome, Centromeric Region Kinetochore Nucleus Nucleoplasm Chromosome Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Protein-containing Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding	Protein Kinase Activity Protein Binding
	Biological Process	Type B Pancreatic Cell Differentiation Type B Pancreatic Cell Development Pancreatic A Cell Fate Commitment Type B Pancreatic Cell Fate Commitment Pancreatic PP Cell Fate Commitment Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Smoothened Signaling Pathway Nervous System Development Brain Development Response To Glucose Positive Regulation Of Gene Expression Oligodendrocyte Development Spinal Cord Motor Neuron Differentiation Spinal Cord Oligodendrocyte Cell Differentiation Spinal Cord Oligodendrocyte Cell Fate Specification Optic Nerve Development Central Nervous System Neuron Differentiation Cell Differentiation Neuron Differentiation Positive Regulation Of Epithelial Cell Differentiation Endocrine Pancreas Development Response To Progesterone Negative Regulation Of Neuron Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Cell Development Digestive Tract Development Neuron Fate Specification Astrocyte Differentiation Oligodendrocyte Differentiation Positive Regulation Of Oligodendrocyte Differentiation Ventral Spinal Cord Interneuron Fate Determination Neuroendocrine Cell Differentiation	Skeletal System Development Ossification Signal Transduction Canonical NF-kappaB Signal Transduction Positive Regulation Of Protein Autophosphorylation Negative Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Apoptotic Process Regulation Of Osteoblast Differentiation Regulation Of Osteoclast Differentiation Positive Regulation Of Protein Kinase Activity Positive Regulation Of JNK Cascade Bone Remodeling Homeostasis Of Number Of Cells Protein Stabilization Regulation Of Non-canonical NF-kappaB Signal Transduction Negative Regulation Of Non-canonical NF-kappaB Signal Transduction
Pathways		Regulation of gene expression in beta cells Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells
Drugs
Diseases
GWAS		Autism spectrum disorder ( 30804558) Chronotype ( 30696823) Ewing sarcoma ( 30093639) Hyperglycemia in higher physical activity ( 30327367) Lupus nephritis in systemic lupus erythematosus ( 24925725) Refractive error ( 32231278)	Refractive error ( 32231278) Suicide attempt severity in mood disorders ( 33783297) Systemic lupus erythematosus ( 24871463)
Interacting Genes		7 interacting genes: CDK5RAP1 DLGAP4 KIZ OLIG2 RASSF2 RECQL SPEF1	11 interacting genes: HRAS IRAK1 KDM1A KIZ KRAS NKX2-2 PRMT3 PRMT6 RASSF5 S100Z SUV39H1
Entrez ID		4821	9770
HPRD ID		05213	15218
Ensembl ID		ENSG00000125820	ENSG00000101265
Uniprot IDs		O95096	P50749
PDB IDs
Enriched GO Terms of Interacting Partners?		Double-stranded DNA Helicase Activity DNA/DNA Annealing Activity Negative Regulation Of Protein Phosphorylation Negative Regulation Of Phosphorylation Spinal Cord Oligodendrocyte Cell Fate Specification Axonemal Central Apparatus Positive Regulation Of Translational Fidelity TRNA-2-methylthio-N(6)-dimethylallyladenosine(37) Synthase Activity Methylthiotransferase Activity TRNA Methylthiolation Negative Regulation Of Phosphate Metabolic Process Spinal Cord Oligodendrocyte Cell Differentiation Oligodendrocyte Cell Fate Specification Axonemal Central Apparatus Assembly Four-way Junction Helicase Activity Positive Regulation Of Protein Autophosphorylation Negative Regulation Of Peptidyl-serine Phosphorylation Glial Cell Fate Specification Regulation Of Neuron Differentiation	Histone Methyltransferase Activity Protein-arginine Omega-N Monomethyltransferase Activity Histone H4R3 Methyltransferase Activity Glial Cell Development Protein-arginine Omega-N Asymmetric Methyltransferase Activity Protein-arginine N-methyltransferase Activity Regulation Of Multicellular Organismal Process Histone H3 Methyltransferase Activity Cellular Response To Gamma Radiation Regulation Of Long-term Neuronal Synaptic Plasticity Methyltransferase Activity Protein-membrane Adaptor Activity Methylation Regulation Of Protein Ubiquitination Regulation Of Neuronal Synaptic Plasticity Response To Gamma Radiation Positive Regulation Of Gene Expression MAPK Cascade Regulation Of Cellular Senescence Positive Regulation Of Neurogenesis Positive Regulation Of Nervous System Development Ventral Spinal Cord Interneuron Fate Determination Type B Pancreatic Cell Fate Commitment Chromatin Remodeling Epigenetic Regulation Of Gene Expression Regulation Of Post-translational Protein Modification Histone H2AR3 Methyltransferase Activity Cellular Senescence Positive Regulation Of Gliogenesis Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription GDP Binding G Protein Activity Regulation Of Macromolecule Metabolic Process Cellular Response To Ionizing Radiation Regulation Of RNA Biosynthetic Process GTPase Complex Ras Protein Signal Transduction Regulation Of Multicellular Organismal Development Pancreatic A Cell Fate Commitment Pancreatic PP Cell Fate Commitment Negative Regulation Of Retinoic Acid Biosynthetic Process Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity Histone H3R2 Methyltransferase Activity Regulation Of Cell Development Regulation Of Neurogenesis Chromatin Organization Positive Regulation Of Cell Population Proliferation Phospholipase C Activator Activity
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