NKX2-2 and DLGAP4

		NKX2-2	DLGAP4
Description		NK2 homeobox 2	DLG associated protein 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Plasma Membrane Membrane Neuromuscular Junction Synapse Glutamatergic Synapse Cholinergic Synapse Postsynaptic Specialization
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding	Protein Binding Molecular Adaptor Activity
	Biological Process	Type B Pancreatic Cell Differentiation Type B Pancreatic Cell Development Pancreatic A Cell Fate Commitment Type B Pancreatic Cell Fate Commitment Pancreatic PP Cell Fate Commitment Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Smoothened Signaling Pathway Nervous System Development Brain Development Response To Glucose Positive Regulation Of Gene Expression Oligodendrocyte Development Spinal Cord Motor Neuron Differentiation Spinal Cord Oligodendrocyte Cell Differentiation Spinal Cord Oligodendrocyte Cell Fate Specification Optic Nerve Development Central Nervous System Neuron Differentiation Cell Differentiation Neuron Differentiation Positive Regulation Of Epithelial Cell Differentiation Endocrine Pancreas Development Response To Progesterone Negative Regulation Of Neuron Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Cell Development Digestive Tract Development Neuron Fate Specification Astrocyte Differentiation Oligodendrocyte Differentiation Positive Regulation Of Oligodendrocyte Differentiation Ventral Spinal Cord Interneuron Fate Determination Neuroendocrine Cell Differentiation	Signaling Modulation Of Chemical Synaptic Transmission Regulation Of Synapse Maturation Modification Of Postsynaptic Structure
Pathways		Regulation of gene expression in beta cells Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells	Neurexins and neuroligins Neurexins and neuroligins
Drugs
Diseases
GWAS		Autism spectrum disorder ( 30804558) Chronotype ( 30696823) Ewing sarcoma ( 30093639) Hyperglycemia in higher physical activity ( 30327367) Lupus nephritis in systemic lupus erythematosus ( 24925725) Refractive error ( 32231278)	Low density lipoprotein cholesterol levels ( 32154731) Neuroblastoma or malignant cutaneous melanoma ( 31605138)
Interacting Genes		7 interacting genes: CDK5RAP1 DLGAP4 KIZ OLIG2 RASSF2 RECQL SPEF1	33 interacting genes: ABI2 ALDH16A1 ATPAF2 BIN1 DLG1 DLG3 DLG4 EXOC4 FHL3 FHL5 FKBP6 FYN GRIN1 GRIN2D MAGEA6 MPP7 MTUS2 NCK1 NCK2 NHERF1 NHERF2 NKX2-2 PALS1 PLP2 PPP1R1B SH3GL2 SH3RF1 SHANK2 SHANK3 SORBS2 SYNGAP1 UBASH3A UBC
Entrez ID		4821	22839
HPRD ID		05213	16826
Ensembl ID		ENSG00000125820	ENSG00000080845
Uniprot IDs		O95096	A0A0B4J2C2 Q9Y2H0
PDB IDs
Enriched GO Terms of Interacting Partners?		Double-stranded DNA Helicase Activity DNA/DNA Annealing Activity Negative Regulation Of Protein Phosphorylation Negative Regulation Of Phosphorylation Spinal Cord Oligodendrocyte Cell Fate Specification Axonemal Central Apparatus Positive Regulation Of Translational Fidelity TRNA-2-methylthio-N(6)-dimethylallyladenosine(37) Synthase Activity Methylthiotransferase Activity TRNA Methylthiolation Negative Regulation Of Phosphate Metabolic Process Spinal Cord Oligodendrocyte Cell Differentiation Oligodendrocyte Cell Fate Specification Axonemal Central Apparatus Assembly Four-way Junction Helicase Activity Positive Regulation Of Protein Autophosphorylation Negative Regulation Of Peptidyl-serine Phosphorylation Glial Cell Fate Specification Regulation Of Neuron Differentiation	Ionotropic Glutamate Receptor Binding Postsynaptic Density Learning Receptor Clustering Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Protein Localization To Membrane Regulation Of Neuronal Synaptic Plasticity Cytoskeletal Anchor Activity Positive Regulation Of Excitatory Postsynaptic Potential Localization Within Membrane Establishment Or Maintenance Of Cell Polarity Learning Or Memory Associative Learning Adherens Junction Postsynaptic Density Membrane Cognition Positive Regulation Of Actin Filament Polymerization Regulation Of Synaptic Plasticity Modulation Of Excitatory Postsynaptic Potential Glutamate Receptor Signaling Pathway Neuron Projection Phosphatase Binding Response To Glycine Type 2 Metabotropic Glutamate Receptor Binding Postsynaptic Density Organization Synapse Regulation Of Cellular Component Size Glutamatergic Synapse Positive Regulation Of Synaptic Transmission Vocalization Behavior Dendritic Spine Regulation Of Actin Filament Organization Scaffold Protein Binding Type 3 Metabotropic Glutamate Receptor Binding Postsynaptic Specialization Organization Signaling Adaptor Activity Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Protein Polymerization Lateral Loop Protein Localization To Cell Junction Regulation Of Translation Initiation In Response To Endoplasmic Reticulum Stress Synaptic Receptor Adaptor Activity Positive Regulation Of Cytoskeleton Organization Chemical Synaptic Transmission Ionotropic Glutamate Receptor Signaling Pathway Regulation Of Biological Quality Plasma Membrane MPP7-DLG1-LIN7 Complex
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