NKX2-2 and RECQL

		NKX2-2	RECQL
Description		NK2 homeobox 2	RecQ like helicase
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Nucleus Nucleoplasm Chromosome Cytoplasm Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding	Nucleotide Binding Nucleic Acid Binding DNA Binding DNA Helicase Activity Helicase Activity Protein Binding ATP Binding Four-way Junction Helicase Activity Hydrolase Activity Isomerase Activity ATP Hydrolysis Activity Double-stranded DNA Helicase Activity 3'-5' DNA Helicase Activity Metal Ion Binding DNA/DNA Annealing Activity
	Biological Process	Type B Pancreatic Cell Differentiation Type B Pancreatic Cell Development Pancreatic A Cell Fate Commitment Type B Pancreatic Cell Fate Commitment Pancreatic PP Cell Fate Commitment Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Smoothened Signaling Pathway Nervous System Development Brain Development Response To Glucose Positive Regulation Of Gene Expression Oligodendrocyte Development Spinal Cord Motor Neuron Differentiation Spinal Cord Oligodendrocyte Cell Differentiation Spinal Cord Oligodendrocyte Cell Fate Specification Optic Nerve Development Central Nervous System Neuron Differentiation Cell Differentiation Neuron Differentiation Positive Regulation Of Epithelial Cell Differentiation Endocrine Pancreas Development Response To Progesterone Negative Regulation Of Neuron Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Cell Development Digestive Tract Development Neuron Fate Specification Astrocyte Differentiation Oligodendrocyte Differentiation Positive Regulation Of Oligodendrocyte Differentiation Ventral Spinal Cord Interneuron Fate Determination Neuroendocrine Cell Differentiation	Double-strand Break Repair Via Homologous Recombination DNA Replication DNA Repair DNA Recombination Replication Fork Processing
Pathways		Regulation of gene expression in beta cells Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells
Drugs
Diseases
GWAS		Autism spectrum disorder ( 30804558) Chronotype ( 30696823) Ewing sarcoma ( 30093639) Hyperglycemia in higher physical activity ( 30327367) Lupus nephritis in systemic lupus erythematosus ( 24925725) Refractive error ( 32231278)	Blood protein levels ( 30072576)
Interacting Genes		7 interacting genes: CDK5RAP1 DLGAP4 KIZ OLIG2 RASSF2 RECQL SPEF1	11 interacting genes: CEBPA E2F4 KPNA2 KPNA4 LINC00632 MARK3 NEIL3 NKX2-2 PLEKHA5 RPA1 UBC
Entrez ID		4821	5965
HPRD ID		05213	02762
Ensembl ID		ENSG00000125820	ENSG00000004700
Uniprot IDs		O95096	P46063
PDB IDs			2V1X 2WWY 4U7D 6JTZ 8YRS
Enriched GO Terms of Interacting Partners?		Double-stranded DNA Helicase Activity DNA/DNA Annealing Activity Negative Regulation Of Protein Phosphorylation Negative Regulation Of Phosphorylation Spinal Cord Oligodendrocyte Cell Fate Specification Axonemal Central Apparatus Positive Regulation Of Translational Fidelity TRNA-2-methylthio-N(6)-dimethylallyladenosine(37) Synthase Activity Methylthiotransferase Activity TRNA Methylthiolation Negative Regulation Of Phosphate Metabolic Process Spinal Cord Oligodendrocyte Cell Differentiation Oligodendrocyte Cell Fate Specification Axonemal Central Apparatus Assembly Four-way Junction Helicase Activity Positive Regulation Of Protein Autophosphorylation Negative Regulation Of Peptidyl-serine Phosphorylation Glial Cell Fate Specification Regulation Of Neuron Differentiation	NLS-dependent Protein Nuclear Import Complex Nucleoplasm NLS-bearing Protein Import Into Nucleus Nuclear Localization Sequence Binding Nuclear Import Signal Receptor Activity Base-excision Repair RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Hippo Signaling Male Germ Cell Nucleus Ventral Spinal Cord Interneuron Fate Determination Type B Pancreatic Cell Fate Commitment MCM Complex Binding Damaged DNA Binding Response To Vitamin B2 C/EBP Complex Entry Of Viral Genome Into Host Nucleus Through Nuclear Pore Complex Via Importin Pancreatic A Cell Fate Commitment Pancreatic PP Cell Fate Commitment Cell Development Chromatin Binding CHOP-C/EBP Complex Histone Deacetylase Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific White Fat Cell Proliferation RNA Polymerase II Transcription Regulator Complex Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Epithelial Cell Development Import Into Nucleus Protein Import Into Nucleus Viral Penetration Into Host Nucleus Spinal Cord Oligodendrocyte Cell Differentiation Oligodendrocyte Cell Fate Specification Spinal Cord Oligodendrocyte Cell Fate Specification Single-stranded Telomeric DNA Binding Single-stranded DNA Binding Depurination
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