ANGPTL2 and EXOSC2

		ANGPTL2	EXOSC2
Description		angiopoietin like 2	exosome component 2
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix Extracellular Exosome	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Nucleolar Exosome (RNase Complex)
	Molecular Function	Signaling Receptor Binding Protein Binding	3'-5'-RNA Exonuclease Activity RNA Binding RNA Exonuclease Activity Protein Binding 7S RNA Binding
	Biological Process	Cell-cell Signaling Blood Coagulation	Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Nuclear-transcribed MRNA Catabolic Process RRNA Processing RNA Processing RNA Catabolic Process Positive Regulation Of Cell Growth U4 SnRNA 3'-end Processing CUT Catabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process TRAMP-dependent TRNA Surveillance Pathway Poly(A)-dependent SnoRNA 3'-end Processing
Pathways			ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay
Drugs
Diseases
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Intraocular pressure ( 30054594) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269)
Interacting Genes		1 interacting genes: EXOSC2	29 interacting genes: ADAMTS13 AMBP ANGPTL2 CACFD1 COLEC12 DIS3 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FBXW2 GALNT13 KHSRP KIFBP MRPL48 MTREX MTX2 NCS1 NELFB PALS2 PTEN RNF8 SBK3 ST6GALNAC1 UPF1 VCAM1 ZNF408
Entrez ID		23452	23404
HPRD ID		05415	03758
Ensembl ID		ENSG00000136859	ENSG00000130713
Uniprot IDs		Q9UKU9	B3KQW2 Q13868
PDB IDs		6Y41	2NN6 6D6Q 6D6R 6H25 9G8M 9G8N 9G8O 9G8P
Enriched GO Terms of Interacting Partners?		Cytoplasmic Exosome (RNase Complex) Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) 7S RNA Binding TRAMP-dependent TRNA Surveillance Pathway TRNA Surveillance TRNA Decay RRNA 3'-end Processing Nucleolar Exosome (RNase Complex) Nuclear Polyadenylation-dependent RRNA Catabolic Process RNA Exonuclease Activity U4 SnRNA 3'-end Processing CUT Catabolic Process Poly(A)-dependent SnoRNA 3'-end Processing Sno(s)RNA Metabolic Process Nuclear Exosome (RNase Complex) Exosome (RNase Complex) SnRNA 3'-end Processing 3'-5'-RNA Exonuclease Activity SnRNA Processing Nuclear RNA Surveillance RNA Surveillance SnRNA Metabolic Process RNA 3'-end Processing Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process Positive Regulation Of Cell Growth TRNA Metabolic Process RNA Catabolic Process RRNA Processing Positive Regulation Of Growth RRNA Metabolic Process Nucleobase-containing Compound Catabolic Process Regulation Of Cell Growth	Exosome (RNase Complex) Nuclear Exosome (RNase Complex) Nuclear MRNA Surveillance Cytoplasmic Exosome (RNase Complex) RRNA Catabolic Process U4 SnRNA 3'-end Processing Nucleolar Exosome (RNase Complex) RNA Exonuclease Activity Exoribonuclease Complex Nuclear RNA Surveillance RNA Surveillance SnRNA 3'-end Processing SnRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process SnRNA Processing RNA Catabolic Process MRNA Catabolic Process MRNA 3'-UTR AU-rich Region Binding 3'-5'-RNA Exonuclease Activity RRNA Processing Nucleobase-containing Compound Catabolic Process U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing RNA 3'-end Processing RRNA Metabolic Process MRNA Metabolic Process Macromolecule Catabolic Process Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance TRAMP-dependent TRNA Surveillance Pathway Nuclear Polyadenylation-dependent RRNA Catabolic Process Poly(A)-dependent SnoRNA 3'-end Processing RRNA 3'-end Processing TRNA Decay DNA Deamination Sno(s)RNA Metabolic Process RNA Processing DNA Modification Nucleolus RNA Binding Catabolic Process RNA Metabolic Process Negative Regulation Of Gene Expression Macromolecule Metabolic Process Nucleic Acid Metabolic Process Histone MRNA Catabolic Process 3'-UTR-mediated MRNA Destabilization Maturation Of 5.8S RRNA Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process
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