EXOSC2 and KIFBP

		EXOSC2	KIFBP
Description		exosome component 2	kinesin family binding protein
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GO Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Nucleolar Exosome (RNase Complex)	Cytoplasm Mitochondrion Cytoskeleton
	Molecular Function	3'-5'-RNA Exonuclease Activity RNA Binding RNA Exonuclease Activity Protein Binding 7S RNA Binding	Protein Binding Kinesin Binding Protein Sequestering Activity
	Biological Process	Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Nuclear-transcribed MRNA Catabolic Process RRNA Processing RNA Processing RNA Catabolic Process Positive Regulation Of Cell Growth U4 SnRNA 3'-end Processing CUT Catabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process TRAMP-dependent TRNA Surveillance Pathway Poly(A)-dependent SnoRNA 3'-end Processing	Microtubule Cytoskeleton Organization In Utero Embryonic Development Nervous System Development Transport Along Microtubule Central Nervous System Projection Neuron Axonogenesis Cell Differentiation Mitochondrion Transport Along Microtubule Neuron Projection Maintenance
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay
Drugs
Diseases			Goldberg-Shprintzen megacolon syndrome; Goldberg-Shprintzen syndrome (GOSHS) Polymicrogyria; Bilateral frontal polymicrogyria (BFP); Bilateral frontoparietal polymicrogyria (BFPP); Bilateral perisylvian polymicrogyria (BPP); Bilateral parasagittal parieto-occipital polymicrogyria (BPOP); Bilateral generalised polymicrogyria (BGP); Unilateral Polymicrogyria (ULP)
GWAS
Interacting Genes		29 interacting genes: ADAMTS13 AMBP ANGPTL2 CACFD1 COLEC12 DIS3 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FBXW2 GALNT13 KHSRP KIFBP MRPL48 MTREX MTX2 NCS1 NELFB PALS2 PTEN RNF8 SBK3 ST6GALNAC1 UPF1 VCAM1 ZNF408	11 interacting genes: ATXN2 CEP76 DOK2 DPEP1 EXOSC2 HBP1 PLEKHF1 RGR TERF1 ZNF638 ZNF670
Entrez ID		23404	26128
HPRD ID		03758	13848
Ensembl ID		ENSG00000130713	ENSG00000198954
Uniprot IDs		B3KQW2 Q13868	Q96EK5
PDB IDs		2NN6 6D6Q 6D6R 6H25 9G8M 9G8N 9G8O 9G8P	6ZPG 6ZPH 7RSI 7RSQ 7RYP 7RYQ
Enriched GO Terms of Interacting Partners?		Exosome (RNase Complex) Nuclear Exosome (RNase Complex) Nuclear MRNA Surveillance Cytoplasmic Exosome (RNase Complex) RRNA Catabolic Process U4 SnRNA 3'-end Processing Nucleolar Exosome (RNase Complex) RNA Exonuclease Activity Exoribonuclease Complex Nuclear RNA Surveillance RNA Surveillance SnRNA 3'-end Processing SnRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process SnRNA Processing RNA Catabolic Process MRNA Catabolic Process MRNA 3'-UTR AU-rich Region Binding 3'-5'-RNA Exonuclease Activity RRNA Processing Nucleobase-containing Compound Catabolic Process U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing RNA 3'-end Processing RRNA Metabolic Process MRNA Metabolic Process Macromolecule Catabolic Process Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance TRAMP-dependent TRNA Surveillance Pathway Nuclear Polyadenylation-dependent RRNA Catabolic Process Poly(A)-dependent SnoRNA 3'-end Processing RRNA 3'-end Processing TRNA Decay DNA Deamination Sno(s)RNA Metabolic Process RNA Processing DNA Modification Nucleolus RNA Binding Catabolic Process RNA Metabolic Process Negative Regulation Of Gene Expression Macromolecule Metabolic Process Nucleic Acid Metabolic Process Histone MRNA Catabolic Process 3'-UTR-mediated MRNA Destabilization Maturation Of 5.8S RRNA Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process	Lactam Catabolic Process Antibiotic Metabolic Process Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Leukotriene D4 Catabolic Process GPI Anchor Binding Beta-lactamase Activity Glutathione Catabolic Process Modified Amino Acid Binding Metallodipeptidase Activity Photoreceptor Activity Regulation Of Establishment Of Protein Localization To Chromosome Nuclear Telomere Cap Complex Regulation Of Establishment Of Protein Localization To Telomere Telomerase Activity Telomere Localization Shelterin Complex Meiotic Telomere Clustering Telomeric D-loop Disassembly Ankyrin Repeat Binding Double-stranded Telomeric DNA Binding Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) 7S RNA Binding TRAMP-dependent TRNA Surveillance Pathway TRNA Surveillance Nuclear Polyadenylation-dependent RRNA Catabolic Process U4 SnRNA 3'-end Processing CUT Catabolic Process Poly(A)-dependent SnoRNA 3'-end Processing
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