EXOSC2 and VCAM1

		EXOSC2	VCAM1
Description		exosome component 2	vascular cell adhesion molecule 1
Image
GO Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Nucleolar Exosome (RNase Complex)	Podosome Extracellular Region Extracellular Space Early Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Microvillus External Side Of Plasma Membrane Cell Surface Membrane Filopodium Sarcolemma Apical Part Of Cell Extracellular Exosome Alpha9-beta1 Integrin-vascular Cell Adhesion Molecule-1 Complex
	Molecular Function	3'-5'-RNA Exonuclease Activity RNA Binding RNA Exonuclease Activity Protein Binding 7S RNA Binding	Integrin Binding Primary Methylamine Oxidase Activity Cell Adhesion Molecule Binding Cell Adhesion Mediator Activity
	Biological Process	Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Nuclear-transcribed MRNA Catabolic Process RRNA Processing RNA Processing RNA Catabolic Process Positive Regulation Of Cell Growth U4 SnRNA 3'-end Processing CUT Catabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process TRAMP-dependent TRNA Surveillance Pathway Poly(A)-dependent SnoRNA 3'-end Processing	Response To Hypoxia Chronic Inflammatory Response Inflammatory Response Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Cell-matrix Adhesion Response To Nutrient Amine Metabolic Process Response To Zinc Ion Response To Ionizing Radiation Membrane To Membrane Docking B Cell Differentiation Response To Lipopolysaccharide Cell-cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Response To Nicotine Cellular Response To Vascular Endothelial Growth Factor Stimulus Positive Regulation Of T Cell Proliferation Response To Ethanol Leukocyte Tethering Or Rolling Cell Chemotaxis Innervation Cardiac Neuron Differentiation Cellular Response To Tumor Necrosis Factor Cell-cell Adhesion Cellular Response To Amyloid-beta
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Integrin cell surface interactions Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling
Drugs			Ethanol Carvedilol Succinobucol Clove oil
Diseases
GWAS			Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Multiple sclerosis ( 21833088 24076602 31604244) Neutrophil percentage of white cells ( 32888494) Sjögren's syndrome ( 24097067)
Interacting Genes		29 interacting genes: ADAMTS13 AMBP ANGPTL2 CACFD1 COLEC12 DIS3 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FBXW2 GALNT13 KHSRP KIFBP MRPL48 MTREX MTX2 NCS1 NELFB PALS2 PTEN RNF8 SBK3 ST6GALNAC1 UPF1 VCAM1 ZNF408	15 interacting genes: CCL17 CCL22 CTSG ELANE ETFA EXOSC2 EZR IL13 ITGAD ITGB1 ITGB7 MSN TRIM54 TRIM65 USP2
Entrez ID		23404	7412
HPRD ID		03758	01888
Ensembl ID		ENSG00000130713	ENSG00000162692
Uniprot IDs		B3KQW2 Q13868	P19320
PDB IDs		2NN6 6D6Q 6D6R 6H25 9G8M 9G8N 9G8O 9G8P	1IJ9 1VCA 1VSC
Enriched GO Terms of Interacting Partners?		Exosome (RNase Complex) Nuclear Exosome (RNase Complex) Nuclear MRNA Surveillance Cytoplasmic Exosome (RNase Complex) RRNA Catabolic Process U4 SnRNA 3'-end Processing Nucleolar Exosome (RNase Complex) RNA Exonuclease Activity Exoribonuclease Complex Nuclear RNA Surveillance RNA Surveillance SnRNA 3'-end Processing SnRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process SnRNA Processing RNA Catabolic Process MRNA Catabolic Process MRNA 3'-UTR AU-rich Region Binding 3'-5'-RNA Exonuclease Activity RRNA Processing Nucleobase-containing Compound Catabolic Process U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing RNA 3'-end Processing RRNA Metabolic Process MRNA Metabolic Process Macromolecule Catabolic Process Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance TRAMP-dependent TRNA Surveillance Pathway Nuclear Polyadenylation-dependent RRNA Catabolic Process Poly(A)-dependent SnoRNA 3'-end Processing RRNA 3'-end Processing TRNA Decay DNA Deamination Sno(s)RNA Metabolic Process RNA Processing DNA Modification Nucleolus RNA Binding Catabolic Process RNA Metabolic Process Negative Regulation Of Gene Expression Macromolecule Metabolic Process Nucleic Acid Metabolic Process Histone MRNA Catabolic Process 3'-UTR-mediated MRNA Destabilization Maturation Of 5.8S RRNA Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process	Immune System Process Immune Response Leukocyte Cell-cell Adhesion Leukocyte Migration Cell Adhesion Molecule Binding Integrin Complex Killing Of Cells Of Another Organism Inflammatory Response Heterotypic Cell-cell Adhesion Cell Migration Defense Response Membrane To Membrane Docking Cell Motility Response To Other Organism Cell Killing Defense Response To Symbiont Positive Regulation Of Early Endosome To Late Endosome Transport Defense Response To Other Organism Positive Regulation Of Protein Localization To Early Endosome Neutrophil-mediated Killing Of Bacterium Filopodium Cell-cell Adhesion Positive Regulation Of Protein Localization To Endosome Response To External Biotic Stimulus Uropod Integrin-mediated Signaling Pathway Cell-matrix Adhesion Establishment Of Epithelial Cell Apical/basal Polarity Mononuclear Cell Migration Regulation Of Early Endosome To Late Endosome Transport Extracellular Space Leukocyte Tethering Or Rolling Neutrophil Mediated Immunity Cell Surface Establishment Of Apical/basal Cell Polarity Leukocyte Adhesion To Vascular Endothelial Cell Polarized Epithelial Cell Differentiation Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Cell Adhesion Mediated By Integrin Microvillus Membrane Gland Morphogenesis Establishment Of Epithelial Cell Polarity Cell-substrate Adhesion Antimicrobial Humoral Response Killing By Host Of Symbiont Cells Cytokine-mediated Signaling Pathway Focal Adhesion T Cell Migration Biological Process Involved In Interaction With Symbiont
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?