EXOSC2 and ST6GALNAC1

Number of citations of the paper that reports this interaction (PubMedID 15231747)
47

Data Source:
BioGRID (two hybrid)

		EXOSC2	ST6GALNAC1
Description		exosome component 2	ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Nucleolar Exosome (RNase Complex)	Golgi Membrane Golgi Apparatus Membrane
	Molecular Function	3'-5'-RNA Exonuclease Activity RNA Binding RNA Exonuclease Activity Protein Binding 7S RNA Binding	Alpha-N-acetylgalactosaminide Alpha-2,6-sialyltransferase Activity Protein Binding Sialyltransferase Activity Transferase Activity Glycosyltransferase Activity
	Biological Process	Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Nuclear-transcribed MRNA Catabolic Process RRNA Processing RNA Processing RNA Catabolic Process Positive Regulation Of Cell Growth U4 SnRNA 3'-end Processing CUT Catabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process TRAMP-dependent TRNA Surveillance Pathway Poly(A)-dependent SnoRNA 3'-end Processing	Protein Glycosylation Oligosaccharide Biosynthetic Process Host-mediated Modulation Of Intestinal Microbiota Composition Host-mediated Perturbation Of Symbiont Process
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay	Sialic acid metabolism
Drugs
Diseases
GWAS
Interacting Genes		29 interacting genes: ADAMTS13 AMBP ANGPTL2 CACFD1 COLEC12 DIS3 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FBXW2 GALNT13 KHSRP KIFBP MRPL48 MTREX MTX2 NCS1 NELFB PALS2 PTEN RNF8 SBK3 ST6GALNAC1 UPF1 VCAM1 ZNF408	3 interacting genes: CFTR EXOSC2 NDST1
Entrez ID		23404	55808
HPRD ID		03758	15340
Ensembl ID		ENSG00000130713	ENSG00000070526
Uniprot IDs		B3KQW2 Q13868	Q9NSC7
PDB IDs		2NN6 6D6Q 6D6R 6H25 9G8M 9G8N 9G8O 9G8P
Enriched GO Terms of Interacting Partners?		Exosome (RNase Complex) Nuclear Exosome (RNase Complex) Nuclear MRNA Surveillance Cytoplasmic Exosome (RNase Complex) RRNA Catabolic Process U4 SnRNA 3'-end Processing Nucleolar Exosome (RNase Complex) RNA Exonuclease Activity Exoribonuclease Complex Nuclear RNA Surveillance RNA Surveillance SnRNA 3'-end Processing SnRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process SnRNA Processing RNA Catabolic Process MRNA Catabolic Process MRNA 3'-UTR AU-rich Region Binding 3'-5'-RNA Exonuclease Activity RRNA Processing Nucleobase-containing Compound Catabolic Process U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing RNA 3'-end Processing RRNA Metabolic Process MRNA Metabolic Process Macromolecule Catabolic Process Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance TRAMP-dependent TRNA Surveillance Pathway Nuclear Polyadenylation-dependent RRNA Catabolic Process Poly(A)-dependent SnoRNA 3'-end Processing RRNA 3'-end Processing TRNA Decay DNA Deamination Sno(s)RNA Metabolic Process RNA Processing DNA Modification Nucleolus RNA Binding Catabolic Process RNA Metabolic Process Negative Regulation Of Gene Expression Macromolecule Metabolic Process Nucleic Acid Metabolic Process Histone MRNA Catabolic Process 3'-UTR-mediated MRNA Destabilization Maturation Of 5.8S RRNA Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process	Positive Regulation Of Anion Channel Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Heparan Sulfate N-sulfotransferase Activity Heparan Sulfate N-deacetylase Activity N-acetylglucosamine Deacetylase Activity Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Positive Regulation Of Enamel Mineralization Transepithelial Water Transport Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Positive Regulation Of Monoatomic Anion Transport Membrane Hyperpolarization Embryonic Neurocranium Morphogenesis Heparin Proteoglycan Biosynthetic Process Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) 7S RNA Binding TRAMP-dependent TRNA Surveillance Pathway TRNA Surveillance Nuclear Polyadenylation-dependent RRNA Catabolic Process U4 SnRNA 3'-end Processing CUT Catabolic Process Poly(A)-dependent SnoRNA 3'-end Processing Amelogenesis ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Deacetylase Activity Embryonic Viscerocranium Morphogenesis RRNA 3'-end Processing Nucleolar Exosome (RNase Complex) TRNA Decay Heparin Proteoglycan Metabolic Process Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport Golgi-associated Vesicle Membrane Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity Cellular Response To Forskolin Animal Organ Morphogenesis Nuclear Exosome (RNase Complex) Response To Forskolin Sno(s)RNA Metabolic Process Exosome (RNase Complex) Chloride Transmembrane Transporter Activity Sperm Capacitation Heparan Sulfate Proteoglycan Biosynthetic Process SnRNA 3'-end Processing
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