ST6GALNAC1 and NDST1

		ST6GALNAC1	NDST1
Description		ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1	N-deacetylase and N-sulfotransferase 1
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Membrane	Golgi Membrane Golgi Apparatus Membrane Trans-Golgi Network Membrane
	Molecular Function	Alpha-N-acetylgalactosaminide Alpha-2,6-sialyltransferase Activity Protein Binding Sialyltransferase Activity Transferase Activity Glycosyltransferase Activity	Catalytic Activity Protein Binding Sulfotransferase Activity Heparan Sulfate N-sulfotransferase Activity Transferase Activity Hydrolase Activity Deacetylase Activity N-acetylglucosamine Deacetylase Activity Heparan Sulfate N-deacetylase Activity
	Biological Process	Protein Glycosylation Oligosaccharide Biosynthetic Process Host-mediated Modulation Of Intestinal Microbiota Composition Host-mediated Perturbation Of Symbiont Process	Polysaccharide Biosynthetic Process Cardiac Septum Development Inflammatory Response Heart Development Respiratory Gaseous Exchange By Respiratory System Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Animal Organ Morphogenesis Heparan Sulfate Proteoglycan Biosynthetic Process Glycosaminoglycan Metabolic Process Heparin Proteoglycan Biosynthetic Process Forebrain Development Midbrain Development Aorta Development Positive Regulation Of MAPK Cascade Positive Regulation Of Smoothened Signaling Pathway Embryonic Neurocranium Morphogenesis Embryonic Viscerocranium Morphogenesis Coronary Vasculature Development
Pathways		Sialic acid metabolism	HS-GAG biosynthesis
Drugs			Adenosine 3',5'-diphosphate
Diseases
GWAS			Appendicular lean mass ( 33097823) Blood protein levels ( 30072576) Cholangiocarcinoma in primary sclerosing cholangitis ( 28779025) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Neutrophil count ( 32888494)
Interacting Genes		3 interacting genes: CFTR EXOSC2 NDST1	9 interacting genes: ABLIM3 ADAM18 CAMK2A HMGXB3 ITGA11 LCOR RUNX1 ST6GALNAC1 SYNPO
Entrez ID		55808	3340
HPRD ID		15340	02912
Ensembl ID		ENSG00000070526	ENSG00000070614
Uniprot IDs		Q9NSC7	A8K8T3 P52848
PDB IDs			1NST 8CCY 8CD0 8CHS
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Anion Channel Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Heparan Sulfate N-sulfotransferase Activity Heparan Sulfate N-deacetylase Activity N-acetylglucosamine Deacetylase Activity Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Positive Regulation Of Enamel Mineralization Transepithelial Water Transport Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Positive Regulation Of Monoatomic Anion Transport Membrane Hyperpolarization Embryonic Neurocranium Morphogenesis Heparin Proteoglycan Biosynthetic Process Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) 7S RNA Binding TRAMP-dependent TRNA Surveillance Pathway TRNA Surveillance Nuclear Polyadenylation-dependent RRNA Catabolic Process U4 SnRNA 3'-end Processing CUT Catabolic Process Poly(A)-dependent SnoRNA 3'-end Processing Amelogenesis ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Deacetylase Activity Embryonic Viscerocranium Morphogenesis RRNA 3'-end Processing Nucleolar Exosome (RNase Complex) TRNA Decay Heparin Proteoglycan Metabolic Process Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport Golgi-associated Vesicle Membrane Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity Cellular Response To Forskolin Animal Organ Morphogenesis Nuclear Exosome (RNase Complex) Response To Forskolin Sno(s)RNA Metabolic Process Exosome (RNase Complex) Chloride Transmembrane Transporter Activity Sperm Capacitation Heparan Sulfate Proteoglycan Biosynthetic Process SnRNA 3'-end Processing
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