ARHGAP5 and SUZ12

		ARHGAP5	SUZ12
Description		Rho GTPase activating protein 5	SUZ12 polycomb repressive complex 2 subunit
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GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Cytosol Plasma Membrane Membrane	Sex Chromatin Nucleus Nucleoplasm Chromatin Silencing Complex Nucleolus RSC-type Complex Nuclear Body Protein-DNA Complex ESC/E(Z) Complex Ribonucleoprotein Complex
	Molecular Function	GTPase Activity GTPase Activator Activity Protein Binding SH2 Domain Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Corepressor Binding Chromatin Binding RNA Binding Protein Binding Enzyme Activator Activity Zinc Ion Binding Chromatin DNA Binding Sequence-specific DNA Binding Metal Ion Binding Histone H3K9me2/3 Reader Activity LncRNA Binding Promoter-specific Chromatin Binding
	Biological Process	Positive Regulation Of Mesenchymal Cell Proliferation Cell Adhesion Signal Transduction Rho Protein Signal Transduction Regulation Of Cell Size Epithelial Cell Migration Positive Regulation Of Epithelial Cell Migration Cell Migration Mammary Gland Development Regulation Of Small GTPase Mediated Signal Transduction	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Differentiation Oligodendrocyte Differentiation Random Inactivation Of X Chromosome Facultative Heterochromatin Formation
Pathways		RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RHOD GTPase cycle RHOQ GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle RHOF GTPase cycle RND3 GTPase cycle RND2 GTPase cycle RND1 GTPase cycle	PRC2 methylates histones and DNA Oxidative Stress Induced Senescence PKMTs methylate histone lysines SUMOylation of chromatin organization proteins Activation of anterior HOX genes in hindbrain development during early embryogenesis Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6 HCMV Early Events Defective pyroptosis Negative Regulation of CDH1 Gene Transcription Regulation of PD-L1(CD274) transcription
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Diseases
GWAS		Asthma ( 29273806)	High chromosomal aberration frequency (chromosome type) ( 31586183) Hip circumference adjusted for BMI ( 25673412)
Interacting Genes		13 interacting genes: ADRB2 CSDE1 FGF13 HSPA13 ITGA5 ITGB1 PTK2B PTPN18 RASA1 RHOA RND3 SMURF2 SUZ12	27 interacting genes: AEBP2 ARHGAP5 BCL11A CDK19 CDK5R1 CDK8 CREB1 EZH2 H1-1 H3-4 KLRC1 LATS2 MED17 MED6 NOL4 NR1D1 PAXIP1 PJA1 PLA2G2A PRDM14 RBBP4 RNF10 SLC2A2 TBC1D29P UBC UBE2I WDR77
Entrez ID		394	23512
HPRD ID		04060	06949
Ensembl ID		ENSG00000100852	ENSG00000178691
Uniprot IDs		Q13017	J3QQW9 Q15022
PDB IDs		2EE4 2EE5 5U4V	4W2R 5HYN 5IJ7 5IJ8 5LS6 5WAI 5WAK 5WG6 6B3W 6C23 6C24 6NQ3 6WKR 7AT8 7KSO 7KSR 7KTP 7TD5 8EQV 8FYH 8T9G 8TAS 8TB9 8VMI 8VML 8VNV 8VNZ 9C8U 9DCH
Enriched GO Terms of Interacting Partners?		Integrin Alpha5-beta1 Complex Wound Healing, Spreading Of Cells Regulation Of Developmental Process Focal Adhesion Cell-cell Adhesion Mediated By Integrin Anatomical Structure Formation Involved In Morphogenesis Plasma Membrane Regulation Of Cell-substrate Adhesion CD40 Signaling Pathway Regulation Of Cytoskeleton Organization Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Ruffle Membrane Integrin-mediated Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Wound Healing, Spreading Of Epidermal Cells Cell-matrix Adhesion Angiogenesis Ruffle Cell Differentiation Negative Regulation Of Anoikis Regulation Of Actin Cytoskeleton Organization Regulation Of Cell-matrix Adhesion Signal Transduction Regulation Of Organelle Organization Contractile Actin Filament Bundle Assembly Stress Fiber Assembly Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Bone Resorption Blood Vessel Diameter Maintenance Regulation Of Tube Size Cell-substrate Adhesion Regulation Of Supramolecular Fiber Organization Neuron Migration Regulation Of Actin Filament-based Process Regulation Of Anoikis Integrin Complex Cell Adhesion Mediated By Integrin LncRNA Binding Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Developmental Process Cerebral Cortex Cell Migration Response To Muscle Activity Positive Regulation Of Excitatory Postsynaptic Potential Cell Surface Receptor Signaling Pathway Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Apoptotic Process Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Angiogenesis	Nucleoplasm Protein Modification Process ESC/E(Z) Complex Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Initiation Positive Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of Transcription Initiation By RNA Polymerase II Protein Modification By Small Protein Conjugation Inner Cell Mass Cell Fate Commitment Regulation Of DNA-templated Transcription Initiation Protein-DNA Complex Assembly Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process CKM Complex Mediator Complex Regulation Of Developmental Process Post-translational Protein Modification Maintenance Of Cell Number Regulation Of RNA Metabolic Process Transcription Coregulator Activity DNA Replication-dependent Chromatin Assembly Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Protein Metabolic Process Transferase Complex Regulation Of Multicellular Organismal Process Regulation Of Primary Metabolic Process Negative Regulation Of RNA Metabolic Process G1 To G0 Transition Chromatin Organization Positive Regulation Of RNA Metabolic Process Protein Ubiquitination Chromatin DNA Binding Response To L-glutamate Regulation Of Cell Differentiation Regulation Of Transcription Elongation By RNA Polymerase II Chromatin Remodeling Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Gliogenesis Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Chromosome Regulation Of DNA-templated Transcription Elongation Rhythmic Process Nucleosome Assembly
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