ARHGAP17 and FNBP1

Number of citations of the paper that reports this interaction (PubMedID 11431473)
0

Data Source:
HPRD (in vitro)

		ARHGAP17	FNBP1
Description		Rho GTPase activating protein 17	formin binding protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Bicellular Tight Junction Membrane Anchoring Junction	Cytoplasm Lysosome Cytosol Cytoskeleton Plasma Membrane Clathrin-coated Pit Cell Cortex Membrane Cytoplasmic Vesicle
	Molecular Function	GTPase Activator Activity Protein Binding SH3 Domain Binding	Protein Binding Lipid Binding Identical Protein Binding
	Biological Process	Signal Transduction Regulation Of Actin Cytoskeleton Organization Regulation Of Rac Protein Signal Transduction Negative Regulation Of Small GTPase Mediated Signal Transduction	Endocytosis Signal Transduction
Pathways		CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOQ GTPase cycle RAC3 GTPase cycle	Clathrin-mediated endocytosis CDC42 GTPase cycle RHOQ GTPase cycle RHOJ GTPase cycle RND2 GTPase cycle
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223)	Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Femur bone mineral density x serum urate levels interaction ( 34046847) Gut microbiota relative abundance (unassigned genus belonging to family Clostridiales) ( 33208821) LDL peak particle diameter (total fat intake interaction) ( 26112879) Pediatric autoimmune diseases ( 26301688) Physiological dysregulation (Mahalanobis distance) ( 32235003)
Interacting Genes		16 interacting genes: ABL1 APP BTK CDC42 CRK CTTN DNMBP FNBP1 GRB2 LCK PACSIN1 PIK3R1 RAC1 SH3GLB1 SRC TRIP10	14 interacting genes: AGTR1 AKAP9 ARHGAP17 CBL CDC42 CEBPA DNM1 FASLG ITSN1 PDE6G RND2 SNX2 TNKS WASL
Entrez ID		55114	23048
HPRD ID		12207	10446
Ensembl ID		ENSG00000140750	ENSG00000187239
Uniprot IDs		Q68EM7	A0A8V8TQ35 A0A994J3U5 A0A994J3V8 B7ZL13 B7ZL14 H0Y7W6 Q96RU3
PDB IDs			2EFL
Enriched GO Terms of Interacting Partners?		Ephrin Receptor Binding Endocytosis Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Cellular Component Organization Actin Cytoskeleton Organization Phosphotyrosine Residue Binding Import Into Cell Actin Filament-based Process Regulation Of Protein-containing Complex Assembly Regulation Of Cell Projection Organization Regulation Of Endocytosis Positive Regulation Of Supramolecular Fiber Organization Cytosol Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Protein-containing Complex Assembly Cell-cell Junction Positive Regulation Of Locomotion Regulation Of Actin Filament-based Process Positive Regulation Of Lamellipodium Organization Regulation Of Supramolecular Fiber Organization Regulation Of Cell-substrate Adhesion Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of MAPK Cascade SH2 Domain Binding Cytoskeleton Organization Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Non-membrane Spanning Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cellular Component Organization Substrate Adhesion-dependent Cell Spreading Regulation Of Actin Filament Organization Phospholipase Activator Activity Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of Lamellipodium Organization B Cell Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Positive Regulation Of Organelle Organization Positive Regulation Of Intracellular Signal Transduction Fc Receptor Signaling Pathway Regulation Of Cell Adhesion Vesicle-mediated Transport Regulation Of Cytoskeleton Organization Regulation Of Substrate Adhesion-dependent Cell Spreading Signal Transduction Regulation Of Organelle Organization Regulation Of Vesicle-mediated Transport Positive Regulation Of Cell Migration Leukocyte Activation Positive Regulation Of Cell Motility	Regulation Of Cellular Component Organization Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cellular Component Organization Positive Regulation Of ERBB Signaling Pathway Positive Regulation Of Endocytosis Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Cytoplasmic Vesicle Regulation Of Plasma Membrane Organization Regulation Of Endocytosis Dendritic Spine Morphogenesis Regulation Of Postsynapse Organization Positive Regulation Of Filopodium Assembly Signal Transduction Positive Regulation Of Transport Endocytosis Dendritic Spine Organization Vesicle Budding From Membrane Protein Kinase Binding Lamellipodium Plasma Membrane Macrophage Differentiation Neuron Projection Organization Regulation Of Filopodium Assembly Postsynapse Organization Angiotensin Type I Receptor Activity Regulation Of Vesicle-mediated Transport Regulation Of Cytoskeleton Organization RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Clathrin Coat Assembly Involved In Endocytosis Positive Regulation Of Receptor-mediated Endocytosis Glutamatergic Synapse Regulation Of Transport Small GTPase-mediated Signal Transduction Bradykinin Receptor Binding Membrane Organization Positive Regulation Of Phosphatidylserine Exposure On Apoptotic Cell Surface Cellular Response To Type II Interferon Import Into Cell Establishment Of Organelle Localization Cell Projection Morphogenesis Actin Filament Organization GBD Domain Binding Storage Vacuole Response To Vitamin B2 C/EBP Complex Vesicle Scission Clathrin-coated Pit Clathrin-dependent Synaptic Vesicle Endocytosis Negative Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Telomeric
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