EMX1 and ELK1

Number of citations of the paper that reports this interaction (PubMedID 20211142)
41

Data Source:
BioGRID (two hybrid)

		EMX1	ELK1
Description		empty spiracles homeobox 1	ETS transcription factor ELK1
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Chromosome Nucleolus Cytoplasm	Chromatin Nucleus Nucleoplasm Dendrite Mitochondrial Membrane Neuronal Cell Body Axon Terminus
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Sequence-specific Double-stranded DNA Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Protein Binding Mediator Complex Binding Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription Regulator Inhibitor Activity Transcription Regulator Activator Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	In Utero Embryonic Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Central Nervous System Development Brain Development Response To Xenobiotic Stimulus Post-embryonic Development Telencephalon Development Cerebral Cortex Regionalization Cerebral Cortex Neuron Differentiation Cerebral Cortex Development Neuron Differentiation Brain Morphogenesis Homeostasis Of Number Of Cells Radial Glial Cell Differentiation Neuroepithelial Cell Differentiation Regulation Of Oligodendrocyte Progenitor Proliferation Neuron Projection Extension	Liver Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Response To Light Stimulus Gene Expression Cell Differentiation Lung Development Response To Ethanol Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Testosterone Stimulus Cellular Response To Lipid Cellular Response To Gamma Radiation Response To Fibroblast Growth Factor Hippocampal Neuron Apoptotic Process
Pathways			ERK/MAPK targets NGF-stimulated transcription HCMV Early Events Estrogen-dependent nuclear events downstream of ESR-membrane signaling Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Drugs
Diseases
GWAS		Malaria ( 31844061) Schizophrenia ( 28991256 30285260)
Interacting Genes		8 interacting genes: ALX4 ELK1 GTF2A1L HOXA10 LINC00839 POLR2D PRDM4 TP63	43 interacting genes: AKAP8 APP BRCA1 CDK6 CEBPB CREBBP CRK EMX1 EP300 EWSR1 FBXO25 FLI1 FOS GRB10 GRB2 HDAC1 HOXB13 ID1 ID2 ID3 KDM6A KLF4 MAD2L2 MAP2K1 MAP2K3 MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK8 MAPK9 MOB4 NFE2L2 PIAS2 PLCG2 SNCA SRF STARD3NL STK16 TAOK2 UBE2I USP17L2
Entrez ID		2016	2002
HPRD ID		08963	02407
Ensembl ID		ENSG00000135638	ENSG00000126767
Uniprot IDs		Q04741	P19419 Q86SR6
PDB IDs			1DUX 5VVT
Enriched GO Terms of Interacting Partners?		DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Embryonic Limb Morphogenesis Transcription By RNA Polymerase II Limb Morphogenesis Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Prostate Gland Development DNA-templated Transcription Positive Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA Binding Skeletal System Development Proximal/distal Pattern Formation Embryonic Hindlimb Morphogenesis Sequence-specific Double-stranded DNA Binding Embryonic Forelimb Morphogenesis Positive Regulation Of Transcription By RNA Polymerase II Hindlimb Morphogenesis Forelimb Morphogenesis Response To Testosterone Hair Follicle Development Gland Development Macromolecule Biosynthetic Process Regionalization Transcription Initiation At RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Nucleobase-containing Compound Biosynthetic Process Ectoderm And Mesoderm Interaction Epidermal Cell Division DNA-templated Transcription Initiation Hair Cycle Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Pattern Specification Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Embryonic Morphogenesis Chromatin RNA Polymerase Complex Positive Regulation Of Somatic Stem Cell Population Maintenance Cloacal Septation Squamous Basal Epithelial Stem Cell Differentiation Involved In Prostate Gland Acinus Development Sequence-specific DNA Binding Neuron Apoptotic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Hippocampal Neuron Apoptotic Process Female Genitalia Morphogenesis	Intracellular Signaling Cassette Regulation Of Macromolecule Biosynthetic Process MAP Kinase Activity Regulation Of Gene Expression Cellular Senescence Stress-activated Protein Kinase Signaling Cascade Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process MAPK Cascade Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Nucleoplasm Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Intracellular Signal Transduction Positive Regulation Of Biosynthetic Process Regulation Of Primary Metabolic Process Stress-activated MAPK Cascade Positive Regulation Of Metabolic Process Regulation Of Immune System Process Protein Serine Kinase Activity Nucleus Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Response To Stress Protein Serine/threonine Kinase Activity Positive Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Cellular Response To Stress Glial Cell Development Response To Growth Factor Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Response To Radiation Response To Peptide Cytoplasm Cellular Response To Oxygen-containing Compound Regulation Of Multicellular Organismal Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Protein Kinase Activity Regulation Of Locomotion Regulation Of Signal Transduction Response To Lipopolysaccharide Anatomical Structure Morphogenesis Response To Lipid
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