EMX1 and HOXA10

Number of citations of the paper that reports this interaction (PubMedID 20211142)
41

Data Source:
BioGRID (two hybrid)

		EMX1	HOXA10
Description		empty spiracles homeobox 1	homeobox A10
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Chromosome Nucleolus Cytoplasm	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Histone Deacetylase Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	In Utero Embryonic Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Central Nervous System Development Brain Development Response To Xenobiotic Stimulus Post-embryonic Development Telencephalon Development Cerebral Cortex Regionalization Cerebral Cortex Neuron Differentiation Cerebral Cortex Development Neuron Differentiation Brain Morphogenesis Homeostasis Of Number Of Cells Radial Glial Cell Differentiation Neuroepithelial Cell Differentiation Regulation Of Oligodendrocyte Progenitor Proliferation Neuron Projection Extension	Skeletal System Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Spermatogenesis Single Fertilization Male Gonad Development Anterior/posterior Pattern Specification Proximal/distal Pattern Formation Regulation Of Gene Expression Embryonic Limb Morphogenesis Prostate Gland Development Response To Testosterone Response To Estrogen Positive Regulation Of Transcription By RNA Polymerase II Uterus Development
Pathways
Drugs			Calcitriol
Diseases
GWAS		Malaria ( 31844061) Schizophrenia ( 28991256 30285260)	Dental caries ( 23259602) Hypertension ( 30487518 31879980) Mean arterial pressure ( 30487518) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		8 interacting genes: ALX4 ELK1 GTF2A1L HOXA10 LINC00839 POLR2D PRDM4 TP63	16 interacting genes: CREBBP EMX1 EP300 FOXO1 GMNN GNG13 HMGB1 MAD1L1 MEIS1 NAB2 PBX1 POLR3D PTPN6 SIRT2 SNAPC1 SPI1
Entrez ID		2016	3206
HPRD ID		08963	00845
Ensembl ID		ENSG00000135638	ENSG00000253293
Uniprot IDs		Q04741	P31260
PDB IDs
Enriched GO Terms of Interacting Partners?		DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Embryonic Limb Morphogenesis Transcription By RNA Polymerase II Limb Morphogenesis Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Prostate Gland Development DNA-templated Transcription Positive Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA Binding Skeletal System Development Proximal/distal Pattern Formation Embryonic Hindlimb Morphogenesis Sequence-specific Double-stranded DNA Binding Embryonic Forelimb Morphogenesis Positive Regulation Of Transcription By RNA Polymerase II Hindlimb Morphogenesis Forelimb Morphogenesis Response To Testosterone Hair Follicle Development Gland Development Macromolecule Biosynthetic Process Regionalization Transcription Initiation At RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Nucleobase-containing Compound Biosynthetic Process Ectoderm And Mesoderm Interaction Epidermal Cell Division DNA-templated Transcription Initiation Hair Cycle Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Pattern Specification Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Embryonic Morphogenesis Chromatin RNA Polymerase Complex Positive Regulation Of Somatic Stem Cell Population Maintenance Cloacal Septation Squamous Basal Epithelial Stem Cell Differentiation Involved In Prostate Gland Acinus Development Sequence-specific DNA Binding Neuron Apoptotic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Hippocampal Neuron Apoptotic Process Female Genitalia Morphogenesis	DNA-binding Transcription Factor Binding Chromatin Binding Positive Regulation Of Innate Immune Response Histone H3K27 Acetyltransferase Activity Megakaryocyte Development Regulation Of Innate Immune Response Positive Regulation Of Defense Response Transcription Regulator Complex Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Nucleus Protein Acetylation Regulation Of Myeloid Progenitor Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Developmental Process Positive Regulation Of Binding Regulation Of Oligodendrocyte Progenitor Proliferation Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Hemopoiesis Positive Regulation Of Immune Response RNA Polymerase II-specific DNA-binding Transcription Factor Binding Chromatin Positive Regulation Of Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA Binding Regulation Of Immune System Process Damaged DNA Binding Transcription Corepressor Activity Regulation Of RNA Metabolic Process Activation Of Innate Immune Response Developmental Process Myeloid Cell Development Regulation Of Cell Differentiation Regulation Of Hemopoiesis Negative Regulation Of Cell-cell Adhesion Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Lymphocyte Differentiation STAT Family Protein Binding Regulation Of Cell Population Proliferation Lymphocyte Activation Sequence-specific DNA Binding Positive Regulation Of RNA Biosynthetic Process
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