ELK1 and HOXB13

Number of citations of the paper that reports this interaction (PubMedID 20211142)
41

Data Source:
BioGRID (two hybrid)

		ELK1	HOXB13
Description		ETS transcription factor ELK1	homeobox B13
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Dendrite Mitochondrial Membrane Neuronal Cell Body Axon Terminus	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Protein Binding Mediator Complex Binding Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription Regulator Inhibitor Activity Transcription Regulator Activator Activity Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Methyl-CpG Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Liver Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Response To Light Stimulus Gene Expression Cell Differentiation Lung Development Response To Ethanol Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Testosterone Stimulus Cellular Response To Lipid Cellular Response To Gamma Radiation Response To Fibroblast Growth Factor Hippocampal Neuron Apoptotic Process	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Morphogenesis Of An Epithelium Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Epidermis Development Response To Wounding Prostate Gland Development Response To Testosterone Regulation Of Growth Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis Epithelial Cell Maturation Involved In Prostate Gland Development
Pathways		ERK/MAPK targets NGF-stimulated transcription HCMV Early Events Estrogen-dependent nuclear events downstream of ESR-membrane signaling Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Drugs
Diseases
GWAS			Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Prostate cancer ( 23104005 23535732)
Interacting Genes		43 interacting genes: AKAP8 APP BRCA1 CDK6 CEBPB CREBBP CRK EMX1 EP300 EWSR1 FBXO25 FLI1 FOS GRB10 GRB2 HDAC1 HOXB13 ID1 ID2 ID3 KDM6A KLF4 MAD2L2 MAP2K1 MAP2K3 MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK8 MAPK9 MOB4 NFE2L2 PIAS2 PLCG2 SNCA SRF STARD3NL STK16 TAOK2 UBE2I USP17L2	8 interacting genes: ALX4 ELK1 HOXD4 IRF4 MEIS1 POU2F1 RAB5C ZNF490
Entrez ID		2002	10481
HPRD ID		02407	05210
Ensembl ID		ENSG00000126767	ENSG00000159184
Uniprot IDs		P19419 Q86SR6	Q4KR72 Q92826
PDB IDs		1DUX 5VVT	2CRA 5EDN 5EEA 5EF6 5EG0 5EGO 5NO6 7PSX 8BYX
Enriched GO Terms of Interacting Partners?		Intracellular Signaling Cassette Regulation Of Macromolecule Biosynthetic Process MAP Kinase Activity Regulation Of Gene Expression Cellular Senescence Stress-activated Protein Kinase Signaling Cascade Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process MAPK Cascade Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Nucleoplasm Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Intracellular Signal Transduction Positive Regulation Of Biosynthetic Process Regulation Of Primary Metabolic Process Stress-activated MAPK Cascade Positive Regulation Of Metabolic Process Regulation Of Immune System Process Protein Serine Kinase Activity Nucleus Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Response To Stress Protein Serine/threonine Kinase Activity Positive Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Cellular Response To Stress Glial Cell Development Response To Growth Factor Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Response To Radiation Response To Peptide Cytoplasm Cellular Response To Oxygen-containing Compound Regulation Of Multicellular Organismal Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Protein Kinase Activity Regulation Of Locomotion Regulation Of Signal Transduction Response To Lipopolysaccharide Anatomical Structure Morphogenesis Response To Lipid	DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin DNA Binding Positive Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Sequence-specific Double-stranded DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Pattern Specification Process Embryonic Skeletal System Morphogenesis Regulation Of Gene Expression Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Skeletal System Morphogenesis Positive Regulation Of Metabolic Process Hippocampal Neuron Apoptotic Process Animal Organ Morphogenesis Embryonic Organ Morphogenesis Regulation Of Macromolecule Metabolic Process Mediator Complex Binding Animal Organ Development Anterior/posterior Pattern Specification Cellular Response To Testosterone Stimulus Regulation Of Metabolic Process Cell Growth Involved In Cardiac Muscle Cell Development Plasma Membrane To Endosome Transport Cellular Developmental Process Transcription Regulator Activator Activity Nucleus Transcription Regulator Complex HMG Box Domain Binding Transcription Cis-regulatory Region Binding T-helper 17 Cell Lineage Commitment Regionalization Lens Morphogenesis In Camera-type Eye Positive Regulation Of Interleukin-13 Production
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