EMX1 and POLR2D

Number of citations of the paper that reports this interaction (PubMedID 20211142)
41

Data Source:
BioGRID (two hybrid)

		EMX1	POLR2D
Description		empty spiracles homeobox 1	RNA polymerase II subunit D
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Chromosome Nucleolus Cytoplasm	DNA-directed RNA Polymerase Complex Nucleus Nucleoplasm RNA Polymerase II, Core Complex Cytosol Nuclear Speck RNA Polymerase Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Sequence-specific Double-stranded DNA Binding	Nucleotide Binding Protein Binding Translation Initiation Factor Binding
	Biological Process	In Utero Embryonic Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Central Nervous System Development Brain Development Response To Xenobiotic Stimulus Post-embryonic Development Telencephalon Development Cerebral Cortex Regionalization Cerebral Cortex Neuron Differentiation Cerebral Cortex Development Neuron Differentiation Brain Morphogenesis Homeostasis Of Number Of Cells Radial Glial Cell Differentiation Neuroepithelial Cell Differentiation Regulation Of Oligodendrocyte Progenitor Proliferation Neuron Projection Extension	DNA-templated Transcription Initiation Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter
Pathways			Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Viral Messenger RNA Synthesis MicroRNA (miRNA) biogenesis Transcriptional regulation by small RNAs PIWI-interacting RNA (piRNA) biogenesis Activation of anterior HOX genes in hindbrain development during early embryogenesis RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes FGFR2 alternative splicing RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes mRNA Capping mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE Signaling by FGFR2 IIIa TM Estrogen-dependent gene expression Inhibition of DNA recombination at telomere
Drugs
Diseases
GWAS		Malaria ( 31844061) Schizophrenia ( 28991256 30285260)	Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549)
Interacting Genes		8 interacting genes: ALX4 ELK1 GTF2A1L HOXA10 LINC00839 POLR2D PRDM4 TP63	16 interacting genes: ATF7IP EMX1 ESR1 HOXC9 IKBKG NR5A2 POLR2A POLR2B POLR2C POLR2E POLR2G POLR2H POLR2K POLR2L TRIM29 ZSCAN1
Entrez ID		2016	5433
HPRD ID		08963	16191
Ensembl ID		ENSG00000135638	ENSG00000144231
Uniprot IDs		Q04741	O15514
PDB IDs			2C35 5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD 6DRD 6O9L 6XRE 7LBM 9EHZ 9EI1 9EI3 9EI4
Enriched GO Terms of Interacting Partners?		DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Embryonic Limb Morphogenesis Transcription By RNA Polymerase II Limb Morphogenesis Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Prostate Gland Development DNA-templated Transcription Positive Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA Binding Skeletal System Development Proximal/distal Pattern Formation Embryonic Hindlimb Morphogenesis Sequence-specific Double-stranded DNA Binding Embryonic Forelimb Morphogenesis Positive Regulation Of Transcription By RNA Polymerase II Hindlimb Morphogenesis Forelimb Morphogenesis Response To Testosterone Hair Follicle Development Gland Development Macromolecule Biosynthetic Process Regionalization Transcription Initiation At RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Nucleobase-containing Compound Biosynthetic Process Ectoderm And Mesoderm Interaction Epidermal Cell Division DNA-templated Transcription Initiation Hair Cycle Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Pattern Specification Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Embryonic Morphogenesis Chromatin RNA Polymerase Complex Positive Regulation Of Somatic Stem Cell Population Maintenance Cloacal Septation Squamous Basal Epithelial Stem Cell Differentiation Involved In Prostate Gland Acinus Development Sequence-specific DNA Binding Neuron Apoptotic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Hippocampal Neuron Apoptotic Process Female Genitalia Morphogenesis	RNA Polymerase II, Core Complex DNA-directed RNA Polymerase Complex DNA-directed RNA Polymerase Activity DNA-templated Transcription Transcription By RNA Polymerase II RNA Polymerase I Complex Nucleobase-containing Compound Biosynthetic Process RNA Polymerase III Complex DNA Binding RNA Metabolic Process Macromolecule Biosynthetic Process Nucleoplasm Nucleic Acid Metabolic Process RNA-directed RNA Polymerase Activity RNA-templated Transcription Regulation Of RNA Metabolic Process Nucleus Transcription By RNA Polymerase III Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Zinc Ion Binding Nucleobase-containing Compound Metabolic Process 5'-3' RNA Polymerase Activity TRNA Transcription By RNA Polymerase III TRNA Transcription Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Nucleolus Sequence-specific Double-stranded DNA Binding Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Ovulation Cycle Process Transcription Coregulator Binding Regulation Of Transcription By RNA Polymerase I Regulation Of Transcription By RNA Polymerase II Zygotic Genome Activation Nuclear Receptor Activity DNA-templated Transcription Elongation Regulation Of Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Glucocorticoid Biosynthetic Process Positive Regulation Of Tendon Cell Differentiation Primary Ovarian Follicle Growth Metal Ion Binding Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Prostate Epithelial Cord Elongation Positive Regulation Of Nitric-oxide Synthase Activity Morula Formation
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