DHFR

Description		dihydrofolate reductase
Image
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol
	Molecular Function	MRNA Regulatory Element Binding Translation Repressor Activity RNA Binding MRNA Binding Dihydrofolate Reductase Activity Protein Binding Folic Acid Binding Oxidoreductase Activity NADP Binding NADPH Binding Sequence-specific MRNA Binding
	Biological Process	Tetrahydrobiopterin Biosynthetic Process One-carbon Metabolic Process Negative Regulation Of Translation Axon Regeneration Response To Methotrexate Dihydrofolate Metabolic Process Tetrahydrofolate Metabolic Process Tetrahydrofolate Biosynthetic Process Folic Acid Metabolic Process Regulation Of Removal Of Superoxide Radicals
Pathways		Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation Metabolism of folate and pterines G1/S-Specific Transcription
Drugs		NADH Pyrimethamine Methotrexate Pemetrexed Gentamicin Proguanil Trimetrexate 2,4-Diamino-5-Methyl-6-[(3,4,5-Trimethoxy-N-Methylanilino)Methyl]Pyrido[2,3-D]Pyrimidine 2,4-Diamino-6-[N-(2',5'-Dimethoxybenzyl)-N-Methylamino]Quinazoline 6-(Octahydro-1h-Indol-1-Ylmethyl)Decahydroquinazoline-2,4-Diamine N6-(2,5-Dimethoxy-Benzyl)-N6-Methyl-Pyrido[2,3-D]Pyrimidine-2,4,6-Triamine 2,4-Diamino-6-[N-(3',4',5'-Trimethoxybenzyl)-N-Methylamino]Pyrido[2,3-D]Pyrimidine Sri-9662 2,4-Diamino-5-(3,4,5-Trimethoxy-Benzyl)-Pyrimidin-1-Ium Sri-9439 Nicotinamide adenine dinucleotide phosphate Piritrexim Biopterin 2,4-Diamino-6-[N-(3',5'-Dimethoxybenzyl)-N-Methylamino]Pyrido[2,3-D]Pyrimidine Iclaprim Pralatrexate 5-[(3R)-3-(5-methoxybiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine 5-[(3R)-3-(5-methoxy-4'-methylbiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine 5-[(3R)-3-(5-methoxy-3',5'-dimethylbiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine 5-[(3R)-3-(5-methoxy-2',6'-dimethylbiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine 5-[3-(2,5-dimethoxyphenyl)prop-1-yn-1-yl]-6-ethylpyrimidine-2,4-diamine [N-(2,4-DIAMINOPTERIDIN-6-YL)-METHYL]-DIBENZ[B,F]AZEPINE (4aS)-5-[(2,4-diaminopteridin-6-yl)methyl]-4a,5-dihydro-2H-dibenzo[b,f]azepin-8-ol (2R,6S)-6-{[methyl(3,4,5-trimethoxyphenyl)amino]methyl}-1,2,5,6,7,8-hexahydroquinazoline-2,4-diamine
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness ( 32963231) Glomerular filtration rate (creatinine) ( 26831199) Huntington's disease progression ( 28642124) Idiopathic downbeat nystagmus ( 32157568) Shingles ( 25297839) Subcortical volume (MOSTest) ( 32665545)
Novel Interacting Genes		18 novel interacting genes: - AMFR ASGR1 CDC42 COPS8 CRHBP DTYMK EXOC4 FKBP1A GKAP1 HSPD1 MDM2 RAE1 RHOQ THBS1 TOMM20 TOMM7 TP53
Interacting Genes		18 interacting genes: - AMFR ASGR1 CDC42 COPS8 CRHBP DTYMK EXOC4 FKBP1A GKAP1 HSPD1 MDM2 RAE1 RHOQ THBS1 TOMM20 TOMM7 TP53
Entrez ID		1719
HPRD ID		00519
Ensembl ID		ENSG00000228716
Uniprot IDs		B0YJ76 B4DM58 P00374
PDB IDs		1BOZ 1DHF 1DLR 1DLS 1DRF 1HFP 1HFQ 1HFR 1KMS 1KMV 1MVS 1MVT 1OHJ 1OHK 1PD8 1PD9 1PDB 1S3U 1S3V 1S3W 1U71 1U72 1YHO 2C2S 2C2T 2DHF 2W3A 2W3B 2W3M 3EIG 3F8Y 3F8Z 3F91 3FS6 3GHC 3GHV 3GHW 3GI2 3GYF 3L3R 3N0H 3NTZ 3NU0 3NXO 3NXR 3NXT 3NXV 3NXX 3NXY 3NZD 3OAF 3S3V 3S7A 4DDR 4G95 4KAK 4KBN 4KD7 4KEB 4KFJ 4M6J 4M6K 4M6L 4QHV 4QJC 5HPB 5HQY 5HQZ 5HSR 5HSU 5HT4 5HT5 5HUI 5HVB 5HVE 5SD6 5SD7 5SD8 5SD9 5SDA 5SDB 6A7C 6A7E 6DAV 6DE4 6VCJ 7ESE 7XI7 8WGN
Enriched GO Terms of Interacting Partners?		GBD Domain Binding Protein Transmembrane Transport Cellular Response To Actinomycin D Migrasome Response To Actinomycin D Protein Localization To Mitochondrion Cellular Response To UV-C Intracellular Signaling Cassette TOM Complex Membrane Organization Mitochondrial Outer Membrane Translocase Complex 'de Novo' Protein Folding Cellular Response To Antibiotic P53 Binding Establishment Of Protein Localization To Mitochondrion Protein Insertion Into Mitochondrial Outer Membrane Response To UV-C Protein-folding Chaperone Binding Ubiquitin Binding Cellular Response To Estrogen Stimulus Secretory Granule Mitochondrion Organization Response To Magnesium Ion Intracellular Signal Transduction Response To Xenobiotic Stimulus Positive Regulation Of Execution Phase Of Apoptosis Negative Regulation Of Protein Processing Mitochondrial Membrane Organization Negative Regulation Of Protein Maturation Protein Import Into Mitochondrial Matrix Positive Regulation Of Filopodium Assembly Amyloid Fibril Formation Protein Refolding Protein Localization To Organelle Positive Regulation Of Macrophage Activation Establishment Of Protein Localization To Organelle Cellular Response To Gamma Radiation Disordered Domain Specific Binding Negative Regulation Of Proteolysis CGMP-mediated Signaling Protein Transmembrane Transporter Activity Phagocytosis, Engulfment Protein Insertion Into Mitochondrial Membrane Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Stability Establishment Of Protein Localization To Mitochondrial Membrane Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Response To Antibiotic Protein-containing Complex Regulation Of Filopodium Assembly
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