PRICKLE1 and ARID2

		PRICKLE1	ARID2
Description		prickle planar cell polarity protein 1	AT-rich interaction domain 2
Image		No pdb structure
GO Annotations	Cellular Component	Proteasome Complex Nucleus Cytoplasm Cytosol Postsynaptic Density Membrane Cell Trailing Edge Nuclear Membrane Glutamatergic Synapse	Kinetochore Chromatin Nucleus Nucleoplasm Plasma Membrane Nuclear Matrix SWI/SNF Complex RSC-type Complex
	Molecular Function	Protein Binding Zinc Ion Binding Protein-containing Complex Binding Metal Ion Binding	DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Neural Tube Closure Tissue Homeostasis Outflow Tract Morphogenesis Protein Import Into Nucleus Apoptotic Process Cytoskeleton Organization Establishment Or Maintenance Of Cell Polarity Epidermal Growth Factor Receptor Signaling Pathway Axonogenesis Heart Development Response To Xenobiotic Stimulus Animal Organ Morphogenesis Tissue Development Gene Expression Programmed Cell Death Wnt Signaling Pathway Vesicle-mediated Transport Dendrite Development Cell Migration Establishment Of Cell Polarity Bone Mineralization Embryonic Limb Morphogenesis Cytoskeleton-dependent Intracellular Transport Neuron Projection Development Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Limb Morphogenesis Multicellular Organism Growth Embryonic Nail Plate Morphogenesis Aorta Development Post-anal Tail Morphogenesis Embryonic Digit Morphogenesis Cilium Organization Establishment Of Protein Localization Negative Regulation Of DNA-templated Transcription Neuron Projection Morphogenesis Response To Electrical Stimulus Cardiac Muscle Cell Development Wnt Signaling Pathway, Planar Cell Polarity Pathway Limb Development Cilium Assembly Face Morphogenesis Mesenchyme Development Coronary Vasculature Development Eyelid Development In Camera-type Eye Establishment Of Bipolar Cell Polarity Involved In Cell Morphogenesis Cornea Development In Camera-type Eye Renal Tubule Development Polarized Secretion Of Basement Membrane Proteins In Epithelium Tear Secretion Basement Membrane Organization Extracellular Matrix Assembly Primitive Streak Formation Negative Regulation Of Canonical Wnt Signaling Pathway Mitotic Spindle Assembly Cell-cell Adhesion Regulation Of Postsynaptic Density Assembly Maintenance Of Postsynaptic Density Structure Focal Adhesion Disassembly Anterior Visceral Endoderm Cell Migration Neuron Projection Extension Embryonic Brain Development Negative Regulation Of Cardiac Muscle Cell Myoblast Differentiation	Heart Morphogenesis Chromatin Organization Nucleosome Disassembly Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cell Population Proliferation Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Cell Migration Homeostatic Process Positive Regulation Of T Cell Differentiation Positive Regulation Of Cell Differentiation Positive Regulation Of Myoblast Differentiation Embryonic Organ Development Cardiac Muscle Cell Proliferation Coronary Artery Morphogenesis Regulation Of G0 To G1 Transition Circulatory System Development Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Double-strand Break Repair Regulation Of Nucleotide-excision Repair
Pathways		Asymmetric localization of PCP proteins	RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Formation of the polybromo-BAF (pBAF) complex
Drugs
Diseases		Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)
GWAS		Appendicular lean mass ( 33097823) Autoimmune thyroid diseases (Graves disease or Hashimoto's thyroiditis) ( 22922229) Blood urea nitrogen levels ( 31152163) Colorectal cancer ( 30529582 31826910) Endometrial cancer (Non-endometrioid histology) ( 30093612) Graves' disease ( 22922229) Heart failure ( 20445134) Hip circumference adjusted for BMI ( 28552196) Impulsivity (non-planning) ( 30718321) Inferior parietal cortex volume ( 31530798) Multiple sclerosis ( 31604244) Night sleep phenotypes ( 27126917) Parkinson's disease ( 27182965) Refractive error ( 32231278) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)	Chronotype ( 30696823) Fish- and plant-related diet ( 32066663) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hippocampal atrophy ( 19668339) Intelligence (MTAG) ( 29326435) Mean corpuscular hemoglobin ( 32888494) Morning person ( 30696823) PR interval ( 32439900) Red blood cell count ( 32888494) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Triglyceride levels ( 32203549) Triglycerides ( 30275531)
Interacting Genes		14 interacting genes: ANO6 ARID2 BYSL CECR2 HIP1R JRK KIF9 LRRK2 PPP3CB PRPF31 SMURF2 TYR UTP14C VIP	10 interacting genes: ANO6 CCNA1 MSRA NFYC PRICKLE1 SMARCA4 SMARCE1 SUMO2 TSC22D2 YAP1
Entrez ID		144165	196528
HPRD ID		16341	16505
Ensembl ID		ENSG00000139174	ENSG00000189079
Uniprot IDs		B3KVG3 B3KVG6 Q96MT3	F8WCU9 Q68CP9
PDB IDs			7VDV 7Y8R
Enriched GO Terms of Interacting Partners?		Regulation Of Synaptic Vesicle Endocytosis Regulation Of Endocytosis Golgi-associated Vesicle Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Dendrite Cytoplasm Regulation Of Synaptic Vesicle Recycling Positive Regulation Of Mitochondrial Membrane Permeability Positive Regulation Of Membrane Permeability Clathrin Binding Lysosome Organization Positive Regulation Of Signal Transduction Regulation Of Vacuole Organization Regulation Of Vesicle-mediated Transport Tyrosinase Activity Eye Pigment Biosynthetic Process Regulation Of CAMP/PKA Signal Transduction Type 2 Vasoactive Intestinal Polypeptide Receptor Binding Type 1 Vasoactive Intestinal Polypeptide Receptor Binding Epinephrine Secretion Regulation Of Canonical Wnt Signaling Pathway Regulation Of Mitochondrial Membrane Permeability Regulation Of Membrane Permeability Positive Regulation Of Clathrin Coat Assembly U4atac SnRNP Ribonucleoprotein Complex Localization ISWI-type Complex Regulation Of Locomotion Cellular Response To Curcumin Caveola Neck Negative Regulation Of Late Endosome To Lysosome Transport Amphisome Peroxidase Inhibitor Activity Negative Regulation Of Protein Processing Involved In Protein Targeting To Mitochondrion GTP-dependent Protein Kinase Activity Beta-catenin Destruction Complex Binding Wnt Signalosome Assembly Activation Of Blood Coagulation Via Clotting Cascade Phosphatidylserine Exposure On Blood Platelet Identical Protein Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Organelle Organization Cell Population Proliferation Melanin Biosynthetic Process From Tyrosine Prolactin Secretion Regulation Of Wnt Signaling Pathway Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway	Positive Regulation Of Stem Cell Population Maintenance Regulation Of Stem Cell Population Maintenance Regulation Of Myoblast Differentiation BBAF Complex NBAF Complex RSC-type Complex NpBAF Complex Nucleosome Disassembly Protein-DNA Complex Disassembly Negative Regulation Of Stem Cell Differentiation Regulation Of Nucleotide-excision Repair SWI/SNF Complex Regulation Of G0 To G1 Transition Nucleosomal DNA Binding L-methionine:thioredoxin-disulfide S-oxidoreductase Activity Peptide-methionine (S)-S-oxide Reductase Activity L-methionine-(S)-S-oxide Reductase Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Transcription Coactivator Activity Positive Regulation Of Myoblast Differentiation Mesenchyme Development Enterocyte Differentiation Anterior Visceral Endoderm Cell Migration Negative Regulation Of Cardiac Muscle Cell Myoblast Differentiation Polarized Secretion Of Basement Membrane Proteins In Epithelium Cell Trailing Edge Phosphatidylserine Exposure On Blood Platelet Regulation Of Wnt Signaling Pathway Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cyclin A1-CDK1 Complex Cyclin A1-CDK2 Complex Regulation Of Stem Cell Differentiation Establishment Of Bipolar Cell Polarity Involved In Cell Morphogenesis Focal Adhesion Disassembly Activation Of Blood Coagulation Via Clotting Cascade Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Double-strand Break Repair Regulation Of Sister Chromatid Segregation Positive Regulation Of Glucose Mediated Signaling Pathway Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Cyclin A2-CDK2 Complex TEAD-YAP Complex Extracellular Matrix Constituent Secretion Tear Secretion
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