ARID2 and ANO6

		ARID2	ANO6
Description		AT-rich interaction domain 2	anoctamin 6
Image			No pdb structure
GO Annotations	Cellular Component	Kinetochore Chromatin Nucleus Nucleoplasm Plasma Membrane Nuclear Matrix SWI/SNF Complex RSC-type Complex	Cytosol Plasma Membrane Cell Surface Membrane Monoatomic Ion Channel Complex Chloride Channel Complex Specific Granule Membrane Extracellular Exosome Tertiary Granule Membrane
	Molecular Function	DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding	Calcium-activated Cation Channel Activity Intracellularly Calcium-gated Chloride Channel Activity Voltage-gated Monoatomic Ion Channel Activity Voltage-gated Chloride Channel Activity Chloride Channel Activity Protein Binding Phospholipid Scramblase Activity Metal Ion Binding Protein Dimerization Activity
	Biological Process	Heart Morphogenesis Chromatin Organization Nucleosome Disassembly Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cell Population Proliferation Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Cell Migration Homeostatic Process Positive Regulation Of T Cell Differentiation Positive Regulation Of Cell Differentiation Positive Regulation Of Myoblast Differentiation Embryonic Organ Development Cardiac Muscle Cell Proliferation Coronary Artery Morphogenesis Regulation Of G0 To G1 Transition Circulatory System Development Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Double-strand Break Repair Regulation Of Nucleotide-excision Repair	Activation Of Blood Coagulation Via Clotting Cascade Monoatomic Ion Transport Chloride Transport Lipid Transport Blood Coagulation Plasma Membrane Phospholipid Scrambling Positive Regulation Of Bone Mineralization Bleb Assembly Monoatomic Ion Transmembrane Transport Positive Regulation Of Monoatomic Ion Transmembrane Transport Purinergic Nucleotide Receptor Signaling Pathway Sodium Ion Transmembrane Transport Positive Regulation Of Apoptotic Process Negative Regulation Of Cell Volume Pore Complex Assembly Positive Regulation Of Phagocytosis, Engulfment Calcium Activated Phosphatidylserine Scrambling Calcium Activated Phosphatidylcholine Scrambling Calcium Ion Transmembrane Transport Positive Regulation Of Monocyte Chemotaxis Phosphatidylserine Exposure On Blood Platelet Chloride Transmembrane Transport Positive Regulation Of Potassium Ion Export Across Plasma Membrane Positive Regulation Of Endothelial Cell Apoptotic Process
Pathways		RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Formation of the polybromo-BAF (pBAF) complex	Stimuli-sensing channels Neutrophil degranulation Induction of Cell-Cell Fusion
Drugs
Diseases
GWAS		Chronotype ( 30696823) Fish- and plant-related diet ( 32066663) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hippocampal atrophy ( 19668339) Intelligence (MTAG) ( 29326435) Mean corpuscular hemoglobin ( 32888494) Morning person ( 30696823) PR interval ( 32439900) Red blood cell count ( 32888494) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Triglyceride levels ( 32203549) Triglycerides ( 30275531)	Ankylosing spondylitis ( 22138694) Insomnia ( 29520036) Urate levels in obese individuals ( 25811787) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		10 interacting genes: ANO6 CCNA1 MSRA NFYC PRICKLE1 SMARCA4 SMARCE1 SUMO2 TSC22D2 YAP1	9 interacting genes: ALG10B ARID2 CPNE8 GXYLT1 LRRK2 MUC19 PRICKLE1 REDIC1 SLC2A13
Entrez ID		196528	196527
HPRD ID		16505	18746
Ensembl ID		ENSG00000189079	ENSG00000177119
Uniprot IDs		F8WCU9 Q68CP9	A0A7P0TBC5 B3KX12 Q4KMQ2
PDB IDs		7VDV 7Y8R
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Stem Cell Population Maintenance Regulation Of Stem Cell Population Maintenance Regulation Of Myoblast Differentiation BBAF Complex NBAF Complex RSC-type Complex NpBAF Complex Nucleosome Disassembly Protein-DNA Complex Disassembly Negative Regulation Of Stem Cell Differentiation Regulation Of Nucleotide-excision Repair SWI/SNF Complex Regulation Of G0 To G1 Transition Nucleosomal DNA Binding L-methionine:thioredoxin-disulfide S-oxidoreductase Activity Peptide-methionine (S)-S-oxide Reductase Activity L-methionine-(S)-S-oxide Reductase Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Transcription Coactivator Activity Positive Regulation Of Myoblast Differentiation Mesenchyme Development Enterocyte Differentiation Anterior Visceral Endoderm Cell Migration Negative Regulation Of Cardiac Muscle Cell Myoblast Differentiation Polarized Secretion Of Basement Membrane Proteins In Epithelium Cell Trailing Edge Phosphatidylserine Exposure On Blood Platelet Regulation Of Wnt Signaling Pathway Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cyclin A1-CDK1 Complex Cyclin A1-CDK2 Complex Regulation Of Stem Cell Differentiation Establishment Of Bipolar Cell Polarity Involved In Cell Morphogenesis Focal Adhesion Disassembly Activation Of Blood Coagulation Via Clotting Cascade Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Double-strand Break Repair Regulation Of Sister Chromatid Segregation Positive Regulation Of Glucose Mediated Signaling Pathway Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Cyclin A2-CDK2 Complex TEAD-YAP Complex Extracellular Matrix Constituent Secretion Tear Secretion	Myo-inositol Transmembrane Transporter Activity Myo-inositol:proton Symporter Activity Cellular Response To Curcumin Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Caveola Neck Negative Regulation Of Late Endosome To Lysosome Transport Amphisome Peroxidase Inhibitor Activity Negative Regulation Of Protein Processing Involved In Protein Targeting To Mitochondrion GTP-dependent Protein Kinase Activity Beta-catenin Destruction Complex Binding Wnt Signalosome Assembly Anterior Visceral Endoderm Cell Migration Negative Regulation Of Cardiac Muscle Cell Myoblast Differentiation Regulation Of Myoblast Differentiation Establishment Of Bipolar Cell Polarity Involved In Cell Morphogenesis Polarized Secretion Of Basement Membrane Proteins In Epithelium Focal Adhesion Disassembly Cell Trailing Edge Dolichyl Pyrophosphate Glc2Man9GlcNAc2 Alpha-1,2-glucosyltransferase Activity UDP-D-xylose:beta-D-glucoside Alpha-1,3-D-xylosyltransferase Activity Myo-inositol Transport Positive Regulation Of Protein Autoubiquitination Response To Curcumin Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Protein Catabolic Process Extracellular Matrix Constituent Secretion Tear Secretion Protein Import Into Nucleus Synaptic Vesicle Growth Cone Cytoplasmic Side Of Mitochondrial Outer Membrane Positive Regulation Of Post-translational Protein Modification Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Import Into Nucleus Positive Regulation Of Dopamine Receptor Signaling Pathway Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Multivesicular Body, Internal Vesicle Regulation Of Postsynapse Organization Regulation Of CAMKK-AMPK Signaling Cascade Regulation Of Branching Morphogenesis Of A Nerve Regulation Of Synaptic Vesicle Transport Embryonic Nail Plate Morphogenesis Maintenance Of Postsynaptic Density Structure UDP-xylosyltransferase Activity Regulation Of Protein Autoubiquitination Positive Regulation Of Synaptic Vesicle Endocytosis Negative Regulation Of Protein Targeting To Mitochondrion Regulation Of Kidney Size
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