PRICKLE1 and CECR2

		PRICKLE1	CECR2
Description		prickle planar cell polarity protein 1	CECR2 histone acetyl-lysine reader
Image		No pdb structure
GO Annotations	Cellular Component	Proteasome Complex Nucleus Cytoplasm Cytosol Postsynaptic Density Membrane Cell Trailing Edge Nuclear Membrane Glutamatergic Synapse	Euchromatin Nucleus ISWI-type Complex CERF Complex
	Molecular Function	Protein Binding Zinc Ion Binding Protein-containing Complex Binding Metal Ion Binding	Protein Binding ATP-dependent Chromatin Remodeler Activity
	Biological Process	Neural Tube Closure Tissue Homeostasis Outflow Tract Morphogenesis Protein Import Into Nucleus Apoptotic Process Cytoskeleton Organization Establishment Or Maintenance Of Cell Polarity Epidermal Growth Factor Receptor Signaling Pathway Axonogenesis Heart Development Response To Xenobiotic Stimulus Animal Organ Morphogenesis Tissue Development Gene Expression Programmed Cell Death Wnt Signaling Pathway Vesicle-mediated Transport Dendrite Development Cell Migration Establishment Of Cell Polarity Bone Mineralization Embryonic Limb Morphogenesis Cytoskeleton-dependent Intracellular Transport Neuron Projection Development Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Limb Morphogenesis Multicellular Organism Growth Embryonic Nail Plate Morphogenesis Aorta Development Post-anal Tail Morphogenesis Embryonic Digit Morphogenesis Cilium Organization Establishment Of Protein Localization Negative Regulation Of DNA-templated Transcription Neuron Projection Morphogenesis Response To Electrical Stimulus Cardiac Muscle Cell Development Wnt Signaling Pathway, Planar Cell Polarity Pathway Limb Development Cilium Assembly Face Morphogenesis Mesenchyme Development Coronary Vasculature Development Eyelid Development In Camera-type Eye Establishment Of Bipolar Cell Polarity Involved In Cell Morphogenesis Cornea Development In Camera-type Eye Renal Tubule Development Polarized Secretion Of Basement Membrane Proteins In Epithelium Tear Secretion Basement Membrane Organization Extracellular Matrix Assembly Primitive Streak Formation Negative Regulation Of Canonical Wnt Signaling Pathway Mitotic Spindle Assembly Cell-cell Adhesion Regulation Of Postsynaptic Density Assembly Maintenance Of Postsynaptic Density Structure Focal Adhesion Disassembly Anterior Visceral Endoderm Cell Migration Neuron Projection Extension Embryonic Brain Development Negative Regulation Of Cardiac Muscle Cell Myoblast Differentiation	Neural Fold Formation Neural Tube Closure Apoptotic DNA Fragmentation Chromatin Organization Chromatin Remodeling Cytoskeleton Organization Single Fertilization Vesicle-mediated Transport Neural Tube Development Inner Ear Receptor Cell Stereocilium Organization Cytoskeleton-dependent Cytokinesis Cochlea Development Execution Phase Of Apoptosis
Pathways		Asymmetric localization of PCP proteins
Drugs
Diseases		Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)
GWAS		Appendicular lean mass ( 33097823) Autoimmune thyroid diseases (Graves disease or Hashimoto's thyroiditis) ( 22922229) Blood urea nitrogen levels ( 31152163) Colorectal cancer ( 30529582 31826910) Endometrial cancer (Non-endometrioid histology) ( 30093612) Graves' disease ( 22922229) Heart failure ( 20445134) Hip circumference adjusted for BMI ( 28552196) Impulsivity (non-planning) ( 30718321) Inferior parietal cortex volume ( 31530798) Multiple sclerosis ( 31604244) Night sleep phenotypes ( 27126917) Parkinson's disease ( 27182965) Refractive error ( 32231278) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)	Waist-to-hip ratio adjusted for BMI x sex interaction ( 26426971)
Interacting Genes		14 interacting genes: ANO6 ARID2 BYSL CECR2 HIP1R JRK KIF9 LRRK2 PPP3CB PRPF31 SMURF2 TYR UTP14C VIP	3 interacting genes: LRPPRC PRICKLE1 UXT
Entrez ID		144165	27443
HPRD ID		16341	10463
Ensembl ID		ENSG00000139174	ENSG00000099954
Uniprot IDs		B3KVG3 B3KVG6 Q96MT3	B7WPH3 Q9BXF3
PDB IDs			3NXB 5V84 8RU1
Enriched GO Terms of Interacting Partners?		Regulation Of Synaptic Vesicle Endocytosis Regulation Of Endocytosis Golgi-associated Vesicle Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Dendrite Cytoplasm Regulation Of Synaptic Vesicle Recycling Positive Regulation Of Mitochondrial Membrane Permeability Positive Regulation Of Membrane Permeability Clathrin Binding Lysosome Organization Positive Regulation Of Signal Transduction Regulation Of Vacuole Organization Regulation Of Vesicle-mediated Transport Tyrosinase Activity Eye Pigment Biosynthetic Process Regulation Of CAMP/PKA Signal Transduction Type 2 Vasoactive Intestinal Polypeptide Receptor Binding Type 1 Vasoactive Intestinal Polypeptide Receptor Binding Epinephrine Secretion Regulation Of Canonical Wnt Signaling Pathway Regulation Of Mitochondrial Membrane Permeability Regulation Of Membrane Permeability Positive Regulation Of Clathrin Coat Assembly U4atac SnRNP Ribonucleoprotein Complex Localization ISWI-type Complex Regulation Of Locomotion Cellular Response To Curcumin Caveola Neck Negative Regulation Of Late Endosome To Lysosome Transport Amphisome Peroxidase Inhibitor Activity Negative Regulation Of Protein Processing Involved In Protein Targeting To Mitochondrion GTP-dependent Protein Kinase Activity Beta-catenin Destruction Complex Binding Wnt Signalosome Assembly Activation Of Blood Coagulation Via Clotting Cascade Phosphatidylserine Exposure On Blood Platelet Identical Protein Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Organelle Organization Cell Population Proliferation Melanin Biosynthetic Process From Tyrosine Prolactin Secretion Regulation Of Wnt Signaling Pathway Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway	Cytoskeleton-dependent Intracellular Transport Mitochondrion Transport Along Microtubule Establishment Of Mitochondrion Localization Beta-tubulin Binding Mitochondrion Localization Organelle Transport Along Microtubule Microtubule-based Process Anterior Visceral Endoderm Cell Migration Negative Regulation Of Cardiac Muscle Cell Myoblast Differentiation Polarized Secretion Of Basement Membrane Proteins In Epithelium Cell Trailing Edge Transport Along Microtubule Intracellular Transport Negative Regulation Of Mitochondrial MRNA Catabolic Process Negative Regulation Of Mitochondrial RNA Catabolic Process Establishment Of Bipolar Cell Polarity Involved In Cell Morphogenesis Focal Adhesion Disassembly Actin Filament Binding Microtubule-based Transport Extracellular Matrix Constituent Secretion Tear Secretion Negative Regulation Of RNA Metabolic Process Microtubule Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Localization Establishment Of Organelle Localization Establishment Of Localization In Cell Mitochondrial MRNA Polyadenylation Embryonic Nail Plate Morphogenesis Gene Expression Maintenance Of Postsynaptic Density Structure Mitochondrial RNA Catabolic Process Microtubule-based Movement Maintenance Of Postsynaptic Specialization Structure Cornea Development In Camera-type Eye RPAP3/R2TP/prefoldin-like Complex Primitive Streak Formation Microtubule Cytoskeleton Organization Organelle Localization Negative Regulation Of Cardiocyte Differentiation Eyelid Development In Camera-type Eye Regulation Of Postsynaptic Density Assembly Negative Regulation Of Macromolecule Metabolic Process Regulation Of Mitochondrial Translation Post-anal Tail Morphogenesis Embryonic Brain Development Regulation Of Postsynaptic Specialization Assembly Regulation Of Excitatory Synapse Assembly Postsynaptic Density Organization Negative Regulation Of Metabolic Process
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