PRICKLE1 and UTP14C

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		PRICKLE1	UTP14C
Description		prickle planar cell polarity protein 1	UTP14C small subunit processome component
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Proteasome Complex Nucleus Cytoplasm Cytosol Postsynaptic Density Membrane Cell Trailing Edge Nuclear Membrane Glutamatergic Synapse	Nucleus Nucleolus Cytosol Small-subunit Processome
	Molecular Function	Protein Binding Zinc Ion Binding Protein-containing Complex Binding Metal Ion Binding	Protein Binding
	Biological Process	Neural Tube Closure Tissue Homeostasis Outflow Tract Morphogenesis Protein Import Into Nucleus Apoptotic Process Cytoskeleton Organization Establishment Or Maintenance Of Cell Polarity Epidermal Growth Factor Receptor Signaling Pathway Axonogenesis Heart Development Response To Xenobiotic Stimulus Animal Organ Morphogenesis Tissue Development Gene Expression Programmed Cell Death Wnt Signaling Pathway Vesicle-mediated Transport Dendrite Development Cell Migration Establishment Of Cell Polarity Bone Mineralization Embryonic Limb Morphogenesis Cytoskeleton-dependent Intracellular Transport Neuron Projection Development Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Limb Morphogenesis Multicellular Organism Growth Embryonic Nail Plate Morphogenesis Aorta Development Post-anal Tail Morphogenesis Embryonic Digit Morphogenesis Cilium Organization Establishment Of Protein Localization Negative Regulation Of DNA-templated Transcription Neuron Projection Morphogenesis Response To Electrical Stimulus Cardiac Muscle Cell Development Wnt Signaling Pathway, Planar Cell Polarity Pathway Limb Development Cilium Assembly Face Morphogenesis Mesenchyme Development Coronary Vasculature Development Eyelid Development In Camera-type Eye Establishment Of Bipolar Cell Polarity Involved In Cell Morphogenesis Cornea Development In Camera-type Eye Renal Tubule Development Polarized Secretion Of Basement Membrane Proteins In Epithelium Tear Secretion Basement Membrane Organization Extracellular Matrix Assembly Primitive Streak Formation Negative Regulation Of Canonical Wnt Signaling Pathway Mitotic Spindle Assembly Cell-cell Adhesion Regulation Of Postsynaptic Density Assembly Maintenance Of Postsynaptic Density Structure Focal Adhesion Disassembly Anterior Visceral Endoderm Cell Migration Neuron Projection Extension Embryonic Brain Development Negative Regulation Of Cardiac Muscle Cell Myoblast Differentiation	RRNA Processing Spermatogenesis Cell Differentiation Ribosome Biogenesis Meiotic Cell Cycle
Pathways		Asymmetric localization of PCP proteins	rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases		Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)
GWAS		Appendicular lean mass ( 33097823) Autoimmune thyroid diseases (Graves disease or Hashimoto's thyroiditis) ( 22922229) Blood urea nitrogen levels ( 31152163) Colorectal cancer ( 30529582 31826910) Endometrial cancer (Non-endometrioid histology) ( 30093612) Graves' disease ( 22922229) Heart failure ( 20445134) Hip circumference adjusted for BMI ( 28552196) Impulsivity (non-planning) ( 30718321) Inferior parietal cortex volume ( 31530798) Multiple sclerosis ( 31604244) Night sleep phenotypes ( 27126917) Parkinson's disease ( 27182965) Refractive error ( 32231278) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)
Interacting Genes		14 interacting genes: ANO6 ARID2 BYSL CECR2 HIP1R JRK KIF9 LRRK2 PPP3CB PRPF31 SMURF2 TYR UTP14C VIP	34 interacting genes: ALAS1 BICD2 C8orf34 CARD10 CCDC57 CEP70 GCC1 GOLGA2 GOLGA6A HOOK1 HOOK2 JRK KANK2 KRT34 KRT40 LZTS2 MCC MEOX2 MTUS2 NAB2 NUDT15 PDE4DIP PIBF1 PRICKLE1 RABEP1 RINT1 RNF10 TEX11 TRAF1 TRAF2 TRIM27 TRIM54 TXLNA USP7
Entrez ID		144165	9724
HPRD ID		16341	12346
Ensembl ID		ENSG00000139174	ENSG00000253797
Uniprot IDs		B3KVG3 B3KVG6 Q96MT3	Q5TAP6
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Synaptic Vesicle Endocytosis Regulation Of Endocytosis Golgi-associated Vesicle Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Dendrite Cytoplasm Regulation Of Synaptic Vesicle Recycling Positive Regulation Of Mitochondrial Membrane Permeability Positive Regulation Of Membrane Permeability Clathrin Binding Lysosome Organization Positive Regulation Of Signal Transduction Regulation Of Vacuole Organization Regulation Of Vesicle-mediated Transport Tyrosinase Activity Eye Pigment Biosynthetic Process Regulation Of CAMP/PKA Signal Transduction Type 2 Vasoactive Intestinal Polypeptide Receptor Binding Type 1 Vasoactive Intestinal Polypeptide Receptor Binding Epinephrine Secretion Regulation Of Canonical Wnt Signaling Pathway Regulation Of Mitochondrial Membrane Permeability Regulation Of Membrane Permeability Positive Regulation Of Clathrin Coat Assembly U4atac SnRNP Ribonucleoprotein Complex Localization ISWI-type Complex Regulation Of Locomotion Cellular Response To Curcumin Caveola Neck Negative Regulation Of Late Endosome To Lysosome Transport Amphisome Peroxidase Inhibitor Activity Negative Regulation Of Protein Processing Involved In Protein Targeting To Mitochondrion GTP-dependent Protein Kinase Activity Beta-catenin Destruction Complex Binding Wnt Signalosome Assembly Activation Of Blood Coagulation Via Clotting Cascade Phosphatidylserine Exposure On Blood Platelet Identical Protein Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Organelle Organization Cell Population Proliferation Melanin Biosynthetic Process From Tyrosine Prolactin Secretion Regulation Of Wnt Signaling Pathway Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway	Microtubule Cytoskeleton Organization Cytoskeleton Organization Cytoskeleton Microtubule-based Process Centrosome Dynein Light Intermediate Chain Binding Cytoplasm Organelle Organization FHF Complex Microtubule Mitotic Spindle Assembly Protein Localization To Perinuclear Region Of Cytoplasm Microtubule Binding Thioesterase Binding Golgi Cis Cisterna Spindle Organization Cytoplasmic Microtubule Organization Regulation Of Microtubule Cytoskeleton Organization Vesicle-mediated Transport HOPS Complex Supramolecular Fiber Organization Cellular Component Assembly Regulation Of Cytoskeleton Organization Cytoskeleton-dependent Intracellular Transport Microtubule Organizing Center Organization Positive Regulation Of Protein Modification Process Mitotic Spindle Organization Spindle Assembly Microtubule Organizing Center Early Endosome To Late Endosome Transport Negative Regulation Of Autophagy Golgi Organization Microtubule Nucleation Intracellular Transport Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Regulation Of Organelle Organization Tumor Necrosis Factor Receptor Binding TORC2 Complex Disassembly Regulation Of Microtubule-based Process Cilium Assembly Meiotic Gene Conversion Primary Ureteric Bud Growth Anterior Visceral Endoderm Cell Migration Negative Regulation Of Cardiac Muscle Cell Myoblast Differentiation Polarized Secretion Of Basement Membrane Proteins In Epithelium Cell Trailing Edge Membraneless Organelle Assembly Golgi Vesicle Transport Microtubule Cytoskeleton Organization Involved In Mitosis
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