TUBB and TTBK1

Number of citations of the paper that reports this interaction (PubMedID 7556643)
0

Data Source:
HPRD (in vitro)

		TUBB	TTBK1
Description		tubulin beta class I	tau tubulin kinase 1
Image
GO Annotations	Cellular Component	Extracellular Region Nucleus Nuclear Envelope Lumen Cytoplasm Cytosol Cytoskeleton Microtubule Microtubule Cytoskeleton Protein-containing Complex Azurophil Granule Lumen Cytoplasmic Ribonucleoprotein Granule Cell Body Membrane Raft Intercellular Bridge Extracellular Exosome Mitotic Spindle	Nucleus Nucleoplasm Cytoplasm Cytosol Microtubule Associated Complex Microtubule Cytoskeleton Neuronal Cell Body Perinuclear Region Of Cytoplasm
	Molecular Function	Nucleotide Binding GTPase Activity Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding GTPase Activating Protein Binding MHC Class I Protein Binding Protein-containing Complex Binding Metal Ion Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity ATP Binding Kinase Activity Transferase Activity Tau Protein Binding Tau-protein Kinase Activity Protein Serine Kinase Activity
	Biological Process	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule-based Process Cytoskeleton-dependent Intracellular Transport Natural Killer Cell Mediated Cytotoxicity Regulation Of Synapse Organization Spindle Assembly Cell Division Odontoblast Differentiation	Signal Transduction Learning Or Memory Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Substantia Nigra Development Positive Regulation Of Protein Polymerization Positive Regulation Of Astrocyte Activation Positive Regulation Of Microglial Cell Activation
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane Neutrophil degranulation AURKA Activation by TPX2 Potential therapeutics for SARS
Drugs		Vinorelbine Vincristine Vinblastine Podofilox Colchicine Epothilone D Patupilone CYT997 CA4P ZEN-012 Tirbanibulin Copper Artenimol Vinflunine Depatuxizumab mafodotin Milataxel Colchiceine
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Decreased fine motor function in Charcot-Marie-Tooth disease 1A (eating with utensils) ( 30958311) Handedness (non-right-handed vs right-handed) ( 31504236) Left-handedness ( 32989287) Left–right brain asymmetry ( 33723403) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Adult hearing difficulty ( 31564434) Autism spectrum disorder or schizophrenia ( 28540026) Automobile speeding propensity ( 30643258) Body size at age 10 ( 32376654) Diastolic blood pressure ( 29403010) Estimated glomerular filtration rate in non-diabetics ( 31451708) General cognitive ability ( 29844566) Hemoglobin ( 32888494) Hip circumference adjusted for BMI ( 34021172) Mean arterial pressure ( 29403010) Pulse pressure ( 28739976) Red blood cell count ( 32888494) Systolic blood pressure ( 26390057 28739976 29403010)
Interacting Genes		85 interacting genes: ADAP2 ALDOA APP ARL8B ATXN3 B4GALT1 BCL2L13 BMPR2 BRCA1 CDH16 CDK1 CDKN2A CLIP1 CMTM5 CNN1 CREBBP CRIPT DISC1 DPYSL2 DUX4 DYNLL1 EML4 ESR1 FXR1 GDAP1 GRM1 HDAC6 HGS HTRA2 HTT LINC01554 LNX2 MAGEA2B MAL2 MAP1A MAP3K10 MAP4 MAP6 MAPRE1 MAPT MARK4 MRGBP MTNR1A MX1 NCALD NCAM1 NCAPH2 NDEL1 NPHP1 OGT PFDN4 PLK1 PRKN PRMT1 PTEN RAB8B RACK1 RASSF1 RSPH1 S100A8 S100A9 SDC3 SPP1 STAU1 SUMO2 SYT9 TAOK2 TBCD TBKBP1 TGM2 TINF2 TPPP TTBK1 TTK TUBA1A UBE3A USP25 VAV1 YWHAB YWHAG YWHAQ YWHAZ ZAP70 ZFYVE21 ZMYND19	5 interacting genes: CDK5R1 CSN1S1 MAP2 MAPT TUBB
Entrez ID		203068	84630
HPRD ID		01852	11653
Ensembl ID		ENSG00000196230	ENSG00000146216
Uniprot IDs		B4DMJ5 B4DQN9 B4DY90 P07437 Q5ST81 Q5SU16	Q5TCY1
PDB IDs		3QNZ 3QO0 5N5N 6I2I 6QUS 6QUY 6QVE 6QVJ 7TRG 7TTN 7TTT 7TUB 7X0S 8BPO 8T42 8U3Z 8V2J 9BP6	4BTJ 4BTK 4BTM 4NFM 4NFN 7JXX 7JXY 7Q8V 7Q8W 7QHW 7ZHN 7ZHO 7ZHP 7ZHQ 8XPZ 9HHW
Enriched GO Terms of Interacting Partners?		Microtubule-based Process Microtubule Cytoskeleton Organization Organelle Organization Microtubule Binding Microtubule Regulation Of Cellular Component Organization Cytoskeleton Organization Microtubule Polymerization Tubulin Binding Identical Protein Binding Microtubule Cytoskeleton Microtubule Associated Complex Positive Regulation Of Cell Communication Positive Regulation Of Signaling Microtubule Polymerization Or Depolymerization Cytoskeleton Cytosol Neuron Projection Regulation Of Ubiquitin-dependent Protein Catabolic Process Beta-tubulin Binding Regulation Of Organelle Organization Cytoplasm Cytoskeleton-dependent Intracellular Transport Protein Polymerization Positive Regulation Of Intracellular Signal Transduction Regulation Of Proteolysis Axon Protein Localization To Organelle Transport Along Microtubule Regulation Of Protein Localization Supramolecular Fiber Organization Positive Regulation Of Cellular Component Organization Regulation Of Signaling Regulation Of Cell Communication Positive Regulation Of Signal Transduction Regulation Of Growth Regulation Of Cellular Response To Stress Apoptotic Process Dendrite Alpha-tubulin Binding Regulation Of Microtubule-based Process Tau Protein Binding Synapse Programmed Cell Death Cell Death Microtubule-based Transport Regulation Of Microtubule Cytoskeleton Organization Axo-dendritic Transport Regulation Of Intracellular Signal Transduction Cilium Disassembly	Main Axon Regulation Of Microtubule Polymerization Regulation Of Microtubule Polymerization Or Depolymerization Microtubule Cytoskeleton Organization Regulation Of Microtubule Cytoskeleton Organization Microtubule-based Process Regulation Of Microtubule-based Process Positive Regulation Of Microtubule Polymerization Cytoskeleton Organization Microtubule Central Nervous System Neuron Development Neuron Projection Neuronal Cell Body Regulation Of Supramolecular Fiber Organization Tubulin Binding Regulation Of Neuron Projection Development Regulation Of Protein-containing Complex Assembly Response To 11-deoxycorticosterone Neuron Projection Development Regulation Of Cytoskeleton Organization Regulation Of Axon Extension Dendrite Apical Distal Dendrite Histone-dependent DNA Binding Positive Regulation Of Protein Polymerization Cell Body Cytoplasmic Ribonucleoprotein Granule Tubulin Complex Microtubule Lateral Binding Regulation Of Plasma Membrane Bounded Cell Projection Organization Dendritic Filopodium Positive Regulation Of Anterograde Synaptic Vesicle Transport Distal Dendrite Positive Regulation Of Anterograde Dense Core Granule Transport Primary Dendrite Regulation Of Cell Projection Organization Neurofibrillary Tangle Assembly Superior Olivary Nucleus Maturation Growth Cone Regulation Of Axonogenesis Dendritic Spine Response To Dehydroepiandrosterone Proximal Neuron Projection Dendritic Branch Protein Kinase 5 Complex Positive Regulation Of Supramolecular Fiber Organization Neuron Development Structural Molecule Activity Regulation Of Anatomical Structure Morphogenesis Positive Regulation Of Vesicle Transport Along Microtubule
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