SLAMF6 and TMPPE

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SLAMF6	TMPPE
Description		SLAM family member 6	transmembrane protein with metallophosphoesterase domain
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane Extracellular Exosome	Membrane
	Molecular Function	Protein Binding	Protein Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Adaptive Immune Response Immune System Process Immune Response Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-17 Production T Cell Activation Innate Immune Response Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity T-helper 17 Cell Lineage Commitment
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Graves' disease ( 23612905) Multiple sclerosis ( 24076602) Rheumatoid arthritis ( 32723749)	Asthma ( 31619474 31959851) Asthma (childhood onset) ( 31036433)
Interacting Genes		11 interacting genes: BRICD5 CLDN19 CXCL14 JAGN1 PTPN11 PTPN6 RABAC1 SH2D1A TMBIM6 TMPPE ZAP70	35 interacting genes: AGTRAP ASGR2 CD79A CLDND2 CLRN1 CNR2 CYB561 FIS1 FXYD6 FXYD6-FXYD2 GPR152 IER3IP1 KCNJ6 KLRC1 LEMD1 MS4A1 PLLP PLPPR1 PNLIPRP1 REEP6 RETREG3 RTP2 SCN3B SFXN5 SLAMF6 SLC38A1 SMAGP SSMEM1 STX3 STX8 TMEM60 TMIE TRARG1 VAMP3 YIPF1
Entrez ID		114836	643853
HPRD ID		05920	18951
Ensembl ID		ENSG00000162739	ENSG00000188167
Uniprot IDs		B4E1U5 Q96DU3	Q6ZT21
PDB IDs		2IF7
Enriched GO Terms of Interacting Partners?		Phosphotyrosine Residue Binding Negative Regulation Of Neutrophil Activation Non-membrane Spanning Protein Tyrosine Phosphatase Activity Regulation Of Neutrophil Activation Neutrophil Activation Involved In Immune Response Leukocyte Mediated Immunity Immune Effector Process Peptidyl-tyrosine Dephosphorylation Platelet Formation Megakaryocyte Development Negative Regulation Of T Cell Receptor Signaling Pathway Regulation Of Lipopolysaccharide-mediated Signaling Pathway Neutrophil Activation Cell Killing Regulation Of T Cell Proliferation Natural Killer Cell Mediated Immunity Natural Killer Cell Mediated Cytotoxicity Leukocyte Activation Negative Regulation Of Immune System Process Immune System Process Regulation Of T Cell Receptor Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Mononuclear Cell Proliferation T Cell Costimulation Myeloid Cell Differentiation Peptidyl-tyrosine Phosphorylation Regulation Of Cell Adhesion Mediated By Integrin Negative Regulation Of Insulin Secretion Negative Regulation Of Peptide Secretion Positive Regulation Of T Cell Activation Cell Activation Epididymis Development Regulation Of Leukocyte Proliferation Negative Regulation Of Cortisol Secretion Negative Regulation Of Growth Hormone Secretion Neuron Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Positive Regulation Of Leukocyte Cell-cell Adhesion Myeloid Cell Development Negative Regulation Of Hormone Secretion Negative Regulation Of Protein Secretion Negative Regulation Of T Cell Proliferation Leukocyte Mediated Cytotoxicity Positive Regulation Of Lymphocyte Activation Positive Regulation Of Cell-cell Adhesion Intestinal Epithelial Cell Migration Endoribonuclease Inhibitor Activity T Cell Aggregation Mesaxon Protein Dephosphorylation Negative Regulation Of Cell Communication	Membrane Plasma Membrane Organelle Membrane Fusion SNAP Receptor Activity Vesicle Fusion SNARE Complex Organelle Fusion Membrane Fusion Vesicle Docking Endoplasmic Reticulum Organization Organelle Localization By Membrane Tethering External Side Of Plasma Membrane Membrane Docking
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?