SLAMF6

Description		SLAM family member 6
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GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	Protein Binding
	Biological Process	Adaptive Immune Response Immune System Process Immune Response Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-17 Production T Cell Activation Innate Immune Response Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity T-helper 17 Cell Lineage Commitment
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Graves' disease ( 23612905) Multiple sclerosis ( 24076602) Rheumatoid arthritis ( 32723749)
Novel Interacting Genes		11 novel interacting genes: BRICD5 CLDN19 CXCL14 JAGN1 PTPN11 PTPN6 RABAC1 SH2D1A TMBIM6 TMPPE ZAP70
Interacting Genes		11 interacting genes: BRICD5 CLDN19 CXCL14 JAGN1 PTPN11 PTPN6 RABAC1 SH2D1A TMBIM6 TMPPE ZAP70
Entrez ID		114836
HPRD ID		05920
Ensembl ID		ENSG00000162739
Uniprot IDs		B4E1U5 Q96DU3
PDB IDs		2IF7
Enriched GO Terms of Interacting Partners?		Phosphotyrosine Residue Binding Negative Regulation Of Neutrophil Activation Non-membrane Spanning Protein Tyrosine Phosphatase Activity Regulation Of Neutrophil Activation Neutrophil Activation Involved In Immune Response Leukocyte Mediated Immunity Immune Effector Process Peptidyl-tyrosine Dephosphorylation Platelet Formation Megakaryocyte Development Negative Regulation Of T Cell Receptor Signaling Pathway Regulation Of Lipopolysaccharide-mediated Signaling Pathway Neutrophil Activation Cell Killing Regulation Of T Cell Proliferation Natural Killer Cell Mediated Immunity Natural Killer Cell Mediated Cytotoxicity Leukocyte Activation Negative Regulation Of Immune System Process Immune System Process Regulation Of T Cell Receptor Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Mononuclear Cell Proliferation T Cell Costimulation Myeloid Cell Differentiation Peptidyl-tyrosine Phosphorylation Regulation Of Cell Adhesion Mediated By Integrin Negative Regulation Of Insulin Secretion Negative Regulation Of Peptide Secretion Positive Regulation Of T Cell Activation Cell Activation Epididymis Development Regulation Of Leukocyte Proliferation Negative Regulation Of Cortisol Secretion Negative Regulation Of Growth Hormone Secretion Neuron Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Positive Regulation Of Leukocyte Cell-cell Adhesion Myeloid Cell Development Negative Regulation Of Hormone Secretion Negative Regulation Of Protein Secretion Negative Regulation Of T Cell Proliferation Leukocyte Mediated Cytotoxicity Positive Regulation Of Lymphocyte Activation Positive Regulation Of Cell-cell Adhesion Intestinal Epithelial Cell Migration Endoribonuclease Inhibitor Activity T Cell Aggregation Mesaxon Protein Dephosphorylation Negative Regulation Of Cell Communication
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