TMPPE and LEMD1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TMPPE	LEMD1
Description		transmembrane protein with metallophosphoesterase domain	LEM domain containing 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Membrane	Membrane
	Molecular Function	Protein Binding Hydrolase Activity Metal Ion Binding	Protein Binding
	Biological Process
Pathways
Drugs
Diseases
GWAS		Asthma ( 31619474 31959851) Asthma (childhood onset) ( 31036433)	Ceramide levels (C22:0) ( 32489964) Ceramide levels (C24:0) ( 32489964) Sleep (1/3-day periodicity) ( 33075057)
Interacting Genes		35 interacting genes: AGTRAP ASGR2 CD79A CLDND2 CLRN1 CNR2 CYB561 FIS1 FXYD6 FXYD6-FXYD2 GPR152 IER3IP1 KCNJ6 KLRC1 LEMD1 MS4A1 PLLP PLPPR1 PNLIPRP1 REEP6 RETREG3 RTP2 SCN3B SFXN5 SLAMF6 SLC38A1 SMAGP SSMEM1 STX3 STX8 TMEM60 TMIE TRARG1 VAMP3 YIPF1	13 interacting genes: AQP6 BLCAP EBP ERMAP JAGN1 MEOX2 MGST3 REEP4 RETREG3 SCN3B SLC16A7 TMPPE ZDHHC15
Entrez ID		643853	93273
HPRD ID		18951	13983
Ensembl ID		ENSG00000188167	ENSG00000186007
Uniprot IDs		Q6ZT21	Q68G75
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Plasma Membrane Organelle Membrane Fusion SNAP Receptor Activity Vesicle Fusion SNARE Complex Organelle Fusion Membrane Fusion Vesicle Docking Endoplasmic Reticulum Organization Organelle Localization By Membrane Tethering External Side Of Plasma Membrane Membrane Docking	Endoplasmic Reticulum Organization Membrane Endoplasmic Reticulum Tubular Network Endoplasmic Reticulum Tubular Network Organization Nitrate Transmembrane Transporter Activity Endoplasmic Reticulum Membrane Endoplasmic Reticulum Pyruvate Secondary Active Transmembrane Transporter Activity Cholesterol-5,6-oxide Hydrolase Activity PH-gated Chloride Channel Activity Nitrate Transmembrane Transport Secondary Active Monocarboxylate Transmembrane Transporter Activity C-8 Sterol Isomerase Activity Cholestenol Delta-isomerase Activity
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