RAB31 and OCRL

Number of citations of the paper that reports this interaction (PubMedID 19795375)
48

Data Source:
BioGRID (pull down)

		RAB31	OCRL
Description		RAB31, member RAS oncogene family	OCRL inositol polyphosphate-5-phosphatase
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GO Annotations	Cellular Component	Phagocytic Cup Cytoplasm Endosome Early Endosome Late Endosome Golgi Apparatus Trans-Golgi Network Cytosol Plasma Membrane Endomembrane System Membrane Secretory Granule Membrane Phagocytic Vesicle Membrane Cytoplasmic Vesicle Early Endosome Membrane Trans-Golgi Network Membrane Early Phagosome Membrane Phagocytic Vesicle	Photoreceptor Outer Segment Nucleus Cytoplasm Lysosome Endosome Early Endosome Golgi Apparatus Golgi Stack Golgi-associated Vesicle Trans-Golgi Network Cytosol Plasma Membrane Clathrin-coated Pit Cilium Microtubule Cytoskeleton Membrane Clathrin-coated Vesicle Phagocytic Vesicle Membrane Cytoplasmic Vesicle Early Endosome Membrane Centriolar Satellite Ciliary Basal Body Cell Projection Neuron Projection
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding	Phosphatidylinositol-4,5-bisphosphate 5-phosphatase Activity Inositol-polyphosphate 5-phosphatase Activity GTPase Activator Activity Protein Binding Hydrolase Activity Phosphatase Activity Small GTPase Binding Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase Activity Phosphatidylinositol Bisphosphate Phosphatase Activity Phosphatidylinositol Phosphate 5-phosphatase Activity Phosphatidylinositol Phosphate 4-phosphatase Activity Phosphatidylinositol-3,5-bisphosphate 5-phosphatase Activity Inositol-1,4,5-trisphosphate 5-phosphatase Activity Inositol-1,3,4,5-tetrakisphosphate 5-phosphatase Activity Inositol Phosphate Phosphatase Activity
	Biological Process	Intracellular Protein Transport Endocytosis Receptor Internalization Cellular Response To Insulin Stimulus Golgi To Plasma Membrane Protein Transport Regulated Exocytosis Golgi Vesicle Transport Positive Regulation Of Phagocytosis, Engulfment Phagosome Maturation	In Utero Embryonic Development Lipid Metabolic Process Phosphatidylinositol Biosynthetic Process Signal Transduction Cell Projection Organization Phosphatidylinositol-3-phosphate Biosynthetic Process Inositol Phosphate Metabolic Process Phosphatidylinositol Metabolic Process Phosphatidylinositol Dephosphorylation Cilium Assembly Membrane Organization
Pathways		Neutrophil degranulation RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs	Synthesis of PIPs at the plasma membrane Synthesis of PIPs at the Golgi membrane Synthesis of IP2, IP, and Ins in the cytosol Synthesis of IP3 and IP4 in the cytosol Golgi Associated Vesicle Biogenesis Clathrin-mediated endocytosis RHOJ GTPase cycle RAC3 GTPase cycle
Drugs
Diseases			Dent disease, including: Dent disease 1; Dent disease 2; X-linked recessive nephrolithiasis ; Hypophosphatemic rickets; Low-molecular-weight proteinuria with hypercalciuria and nephrocalcinosis Lowe syndrome; Oculocerebrorenal Dystrophy (OCRL)
GWAS		Age at first sexual intercourse ( 27089180) Basophil count ( 32888494) Blood pressure (age interaction) ( 24954895) Bone fracture in osteoporosis ( 28580392) Dupuytren's disease ( 28886342) Lung adenocarcinoma ( 28604730)
Interacting Genes		7 interacting genes: ALS2CL EEA1 EGFR IRAK1 MAPK6 MPP3 OCRL	14 interacting genes: CDC42 CLTC GOLGA5 GRB2 LHX3 RAB14 RAB1A RAB31 RAB5A RAB6A RAB8A RAC1 TFAP2A TYMS
Entrez ID		11031	4952
HPRD ID		05751	02395
Ensembl ID		ENSG00000168461	ENSG00000122126
Uniprot IDs		Q13636	A0A2X0TVZ9 Q01968 Q504W7
PDB IDs		2FG5	2KIE 2QV2 3QBT 3QIS 4CMN
Enriched GO Terms of Interacting Partners?		Early Endosome Membrane MAPK Cascade Kinase Activity Protein Kinase Activity Epidermal Growth Factor Binding Positive Regulation Of Protein Kinase C Signaling Epidermal Growth Factor Receptor Activity Shc-EGFR Complex Multivesicular Body, Internal Vesicle Lumen Inositol Phosphate Phosphatase Activity Phosphatidylinositol Phosphate 5-phosphatase Activity Phosphatidylinositol Bisphosphate Phosphatase Activity Phosphatidylinositol Phosphate 4-phosphatase Activity Septin Cytoskeleton Postsynaptic Early Endosome Axonal Spine Chemical Synaptic Transmission, Postsynaptic Synaptic Vesicle To Endosome Fusion	GTPase Activity Vesicle-mediated Transport GTP Binding G Protein Activity Phagocytic Vesicle Endocytosis Intracellular Protein Transport Import Into Cell Receptor Internalization Trans-Golgi Network Myosin V Binding GDP Binding Cellular Localization Endosome Intracellular Transport Melanosome Intracellular Protein Localization Trans-Golgi Network Membrane Endosomal Transport Endomembrane System Cytoplasmic Vesicle Golgi Vesicle Transport Golgi Organization Extracellular Exosome Golgi Membrane Establishment Of Localization In Cell Protein Transport Receptor-mediated Endocytosis Hydrolase Activity G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Amyloid-beta Clearance By Transcytosis Regulation Of Neuronal Synaptic Plasticity Early Endosome Membrane Nucleotide Binding Protein Kinase Binding Establishment Of Protein Localization Thioesterase Binding Plasma Membrane Bounded Cell Projection Organization Golgi Apparatus Phagocytic Vesicle Membrane Phagosome Maturation Organelle Transport Along Microtubule Localization Within Membrane Secretory Granule Membrane Retrograde Transport, Endosome To Golgi Recycling Endosome Membrane Trans-Golgi Network Transport Vesicle Early Endosome To Golgi Transport Protein Localization To Membrane Anatomical Structure Arrangement
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