RAB31 and ALS2CL

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RAB31	ALS2CL
Description		RAB31, member RAS oncogene family	ALS2 C-terminal like
Image			No pdb structure
GO Annotations	Cellular Component	Phagocytic Cup Cytoplasm Endosome Early Endosome Late Endosome Golgi Apparatus Trans-Golgi Network Cytosol Plasma Membrane Endomembrane System Membrane Secretory Granule Membrane Phagocytic Vesicle Membrane Cytoplasmic Vesicle Early Endosome Membrane Trans-Golgi Network Membrane Early Phagosome Membrane Phagocytic Vesicle	Cytoplasm Cytosol Cytoplasmic Vesicle
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Small GTPase Binding
	Biological Process	Intracellular Protein Transport Endocytosis Receptor Internalization Cellular Response To Insulin Stimulus Golgi To Plasma Membrane Protein Transport Regulated Exocytosis Golgi Vesicle Transport Positive Regulation Of Phagocytosis, Engulfment Phagosome Maturation	Endosomal Transport
Pathways		Neutrophil degranulation RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs	RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS		Age at first sexual intercourse ( 27089180) Basophil count ( 32888494) Blood pressure (age interaction) ( 24954895) Bone fracture in osteoporosis ( 28580392) Dupuytren's disease ( 28886342) Lung adenocarcinoma ( 28604730)
Interacting Genes		7 interacting genes: ALS2CL EEA1 EGFR IRAK1 MAPK6 MPP3 OCRL	7 interacting genes: EEF1AKMT3 RAB22A RAB31 RAB5A RAB5C RSPH14 SAXO4
Entrez ID		11031	259173
HPRD ID		05751	10643
Ensembl ID		ENSG00000168461	ENSG00000178038
Uniprot IDs		Q13636	Q60I27
PDB IDs		2FG5
Enriched GO Terms of Interacting Partners?		Early Endosome Membrane MAPK Cascade Kinase Activity Protein Kinase Activity Epidermal Growth Factor Binding Positive Regulation Of Protein Kinase C Signaling Epidermal Growth Factor Receptor Activity Shc-EGFR Complex Multivesicular Body, Internal Vesicle Lumen Inositol Phosphate Phosphatase Activity Phosphatidylinositol Phosphate 5-phosphatase Activity Phosphatidylinositol Bisphosphate Phosphatase Activity Phosphatidylinositol Phosphate 4-phosphatase Activity Septin Cytoskeleton Postsynaptic Early Endosome Axonal Spine Chemical Synaptic Transmission, Postsynaptic Synaptic Vesicle To Endosome Fusion	GDP Binding Early Endosome Endomembrane System GTPase Activity Phagocytic Vesicle Phagocytic Vesicle Membrane Plasma Membrane To Endosome Transport GTP Binding Endocytosis Regulation Of Vesicle Size Intracellular Protein Transport Import Into Cell Early Endosome Membrane Endosome Receptor Internalization Endocytic Vesicle G Protein Activity Protein Transport Endosome Organization Vesicle-mediated Transport Intracellular Transport Melanosome Ruffle Cell Projection Establishment Of Protein Localization Regulation Of Vesicle-mediated Transport Protein Localization To Early Endosome Early Phagosome Membrane Cytoplasmic Side Of Early Endosome Membrane Cellular Localization Late Endosome Establishment Of Localization In Cell Receptor-mediated Endocytosis Nucleotide Binding Amyloid-beta Clearance By Transcytosis Intracellular Protein Localization Motile Cilium Cytoplasmic Vesicle Regulation Of Cellular Component Size Regulation Of Endosome Size Endosomal Transport Phagosome Maturation Early Phagosome Radial Spoke Actin Cytoskeleton Endosome Membrane Protein Localization To Endosome Positive Regulation Of Phagocytosis, Engulfment Synaptic Vesicle Recycling Somatodendritic Compartment
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