OCRL and RAB6A

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo, two hybrid, in vitro)

		OCRL	RAB6A
Description		OCRL inositol polyphosphate-5-phosphatase	RAB6A, member RAS oncogene family
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GO Annotations	Cellular Component	Photoreceptor Outer Segment Nucleus Cytoplasm Lysosome Endosome Early Endosome Golgi Apparatus Golgi Stack Golgi-associated Vesicle Trans-Golgi Network Cytosol Plasma Membrane Clathrin-coated Pit Cilium Microtubule Cytoskeleton Membrane Clathrin-coated Vesicle Phagocytic Vesicle Membrane Cytoplasmic Vesicle Early Endosome Membrane Centriolar Satellite Ciliary Basal Body Cell Projection Neuron Projection	Golgi Membrane Acrosomal Membrane Nucleoplasm Endoplasmic Reticulum Membrane Golgi Apparatus Trans-Golgi Network Cytosol Plasma Membrane Endomembrane System Membrane Secretory Granule Membrane Cytoplasmic Vesicle Trans-Golgi Network Membrane Ciliary Basal Body Extracellular Exosome Endosome To Plasma Membrane Transport Vesicle
	Molecular Function	Phosphatidylinositol-4,5-bisphosphate 5-phosphatase Activity Inositol-polyphosphate 5-phosphatase Activity GTPase Activator Activity Protein Binding Hydrolase Activity Phosphatase Activity Small GTPase Binding Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase Activity Phosphatidylinositol Bisphosphate Phosphatase Activity Phosphatidylinositol Phosphate 5-phosphatase Activity Phosphatidylinositol Phosphate 4-phosphatase Activity Phosphatidylinositol-3,5-bisphosphate 5-phosphatase Activity Inositol-1,4,5-trisphosphate 5-phosphatase Activity Inositol-1,3,4,5-tetrakisphosphate 5-phosphatase Activity Inositol Phosphate Phosphatase Activity	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity Protein Domain Specific Binding Myosin V Binding
	Biological Process	In Utero Embryonic Development Lipid Metabolic Process Phosphatidylinositol Biosynthetic Process Signal Transduction Cell Projection Organization Phosphatidylinositol-3-phosphate Biosynthetic Process Inositol Phosphate Metabolic Process Phosphatidylinositol Metabolic Process Phosphatidylinositol Dephosphorylation Cilium Assembly Membrane Organization	Intracellular Protein Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Intra-Golgi Vesicle-mediated Transport Protein Transport Vesicle-mediated Transport Peptidyl-cysteine Methylation Antigen Processing And Presentation Neuron Projection Development Protein Localization To Golgi Apparatus Early Endosome To Golgi Transport Retrograde Transport, Endosome To Golgi Minus-end-directed Organelle Transport Along Microtubule Protein Localization To Golgi Membrane
Pathways		Synthesis of PIPs at the plasma membrane Synthesis of PIPs at the Golgi membrane Synthesis of IP2, IP, and Ins in the cytosol Synthesis of IP3 and IP4 in the cytosol Golgi Associated Vesicle Biogenesis Clathrin-mediated endocytosis RHOJ GTPase cycle RAC3 GTPase cycle	Pre-NOTCH Processing in Golgi Neutrophil degranulation COPI-independent Golgi-to-ER retrograde traffic Retrograde transport at the Trans-Golgi-Network TBC/RABGAPs RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases		Dent disease, including: Dent disease 1; Dent disease 2; X-linked recessive nephrolithiasis ; Hypophosphatemic rickets; Low-molecular-weight proteinuria with hypercalciuria and nephrocalcinosis Lowe syndrome; Oculocerebrorenal Dystrophy (OCRL)
GWAS			Dimensional psychopathology (Cognitive) ( 29496196) Obesity-related traits ( 23251661)
Interacting Genes		14 interacting genes: CDC42 CLTC GOLGA5 GRB2 LHX3 RAB14 RAB1A RAB31 RAB5A RAB6A RAB8A RAC1 TFAP2A TYMS	24 interacting genes: BICD1 BICD2 CHM CHML DCTN1 ERC1 FKBP2 GDI1 GOLGA1 GOLGA2 GOLGA4 GORAB KIF20A OCRL PMM1 RAB7A RABAC1 RABGAP1 RABGGTB SHANK2 SYTL5 TIAM1 TMEM132D TMF1
Entrez ID		4952	5870
HPRD ID		02395	01543
Ensembl ID		ENSG00000122126	ENSG00000175582
Uniprot IDs		A0A2X0TVZ9 Q01968 Q504W7	A0A024R5J5 P20340 Q53ET8
PDB IDs		2KIE 2QV2 3QBT 3QIS 4CMN	1YZQ 2GIL 3BBP 3CWZ 4DKX 5LEF
Enriched GO Terms of Interacting Partners?		GTPase Activity Vesicle-mediated Transport GTP Binding G Protein Activity Phagocytic Vesicle Endocytosis Intracellular Protein Transport Import Into Cell Receptor Internalization Trans-Golgi Network Myosin V Binding GDP Binding Cellular Localization Endosome Intracellular Transport Melanosome Intracellular Protein Localization Trans-Golgi Network Membrane Endosomal Transport Endomembrane System Cytoplasmic Vesicle Golgi Vesicle Transport Golgi Organization Extracellular Exosome Golgi Membrane Establishment Of Localization In Cell Protein Transport Receptor-mediated Endocytosis Hydrolase Activity G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Amyloid-beta Clearance By Transcytosis Regulation Of Neuronal Synaptic Plasticity Early Endosome Membrane Nucleotide Binding Protein Kinase Binding Establishment Of Protein Localization Thioesterase Binding Plasma Membrane Bounded Cell Projection Organization Golgi Apparatus Phagocytic Vesicle Membrane Phagosome Maturation Organelle Transport Along Microtubule Localization Within Membrane Secretory Granule Membrane Retrograde Transport, Endosome To Golgi Recycling Endosome Membrane Trans-Golgi Network Transport Vesicle Early Endosome To Golgi Transport Protein Localization To Membrane Anatomical Structure Arrangement	Small GTPase Binding Golgi Apparatus Vesicle-mediated Transport Rab-protein Geranylgeranyltransferase Complex Protein Geranylgeranylation Cellular Localization Intracellular Transport Protein Prenylation Microtubule Anchoring At Microtubule Organizing Center Protein Transport GDP-dissociation Inhibitor Activity Establishment Of Localization In Cell Establishment Of Protein Localization Microtubule Anchoring Intracellular Protein Localization Minus-end-directed Organelle Transport Along Microtubule Rab Geranylgeranyltransferase Activity GTPase Activator Activity Golgi Vesicle Transport Organelle Assembly Cytosol Trans-Golgi Network Cytoplasm Positive Regulation Of Axonogenesis Microtubule-based Movement Dynactin Binding Microtubule Cytoskeleton Organization Retrograde Transport, Endosome To Golgi Dynein Complex Binding Retromer Complex Cytoskeletal Anchor Activity Small GTPase-mediated Signal Transduction Establishment Of Organelle Localization Microtubule-based Process Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Cytosolic Transport Maintenance Of Synapse Structure Vesicle-mediated Transport To The Plasma Membrane Cytoplasmic Vesicle Mitotic Spindle Regulation Of Axonogenesis Microtubule Associated Complex Positive Regulation Of Axon Extension GTPase Binding Synaptic Vesicle Recycling Via Endosome Neuronal Cell Body Regulation Of Microtubule Cytoskeleton Organization Golgi Membrane Transport Along Microtubule Centrosome
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