TRAFD1 and ESPL1

		TRAFD1	ESPL1
Description		TRAF-type zinc finger domain containing 1	extra spindle pole bodies like 1, separase
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GO Annotations	Cellular Component	Mitochondrion	Nucleus Cytoplasm Centrosome Cytosol Mitotic Spindle
	Molecular Function	Protein Binding Zinc Ion Binding Metal Ion Binding	Catalytic Activity Cysteine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity
	Biological Process	Negative Regulation Of Innate Immune Response	Mitotic Sister Chromatid Segregation Meiotic Spindle Organization Mitotic Cell Cycle Nuclear Division Mitotic Cytokinesis Proteolysis Apoptotic Process Chromosome Segregation Meiosis I Establishment Of Mitotic Spindle Localization Homologous Chromosome Segregation Positive Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Sister Chromatid Cohesion Mitotic Sister Chromatid Separation Meiotic Chromosome Separation Nuclear Chromosome Segregation
Pathways			Separation of Sister Chromatids
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 30718733) Alcohol consumption (max-drinks) ( 29460428) Alcohol dependence symptom count ( 29460428) Aspartate aminotransferase levels ( 30718733) Body mass index ( 25673413 26426971) Coffee consumption ( 29367735) Confectionary intake ( 33632354) Hemoglobin ( 19862010) Hemoglobin levels ( 32327693) Neutrophil count ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494) Primary biliary cholangitis ( 26394269) Response to alcohol consumption (flushing response) ( 29460428) Spleen volume ( 34128465) Systemic lupus erythematosus ( 28714469) Type 1 diabetes ( 17554300) White blood cell count ( 32888494)	Femoral neck bone mineral density ( 29499414) Lumbar spine bone mineral density ( 29499414)
Interacting Genes		9 interacting genes: CFTR ESPL1 HTT KCNMB4 NGLY1 PRPF40B PTPRD TRAF6 UBC	8 interacting genes: MTNR1B PJA1 RFFL TRAFD1 TRIM55 TRIM63 USP21 USP28
Entrez ID		10906	9700
HPRD ID		10994	06825
Ensembl ID		ENSG00000135148	ENSG00000135476
Uniprot IDs		O14545	Q14674
PDB IDs		2D9K	7NJ0 7NJ1
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Ion Transmembrane Transporter Activity Positive Regulation Of Transporter Activity Odontogenesis Of Dentin-containing Tooth Endosome Membrane Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Establishment Of Spindle Localization Establishment Of Mitotic Spindle Localization Spindle Localization Peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine Amidase Activity	Post-translational Protein Modification Ubiquitin Protein Ligase Activity Protein Modification Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Metabolic Process Zinc Ion Binding Cysteine-type Deubiquitinase Activity Protein Deubiquitination Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Protein K48-linked Ubiquitination Protein Modification By Small Protein Removal Metal Ion Binding Cysteine-type Peptidase Activity Melatonin Receptor Activity Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Positive Regulation Of Transmission Of Nerve Impulse Positive Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of CGMP-mediated Signaling Regulation Of Neuronal Action Potential Negative Regulation Of Transmission Of Nerve Impulse Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep DeNEDDylase Activity Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Diapedesis Skeletal Muscle Atrophy Skeletal Muscle Adaptation Striated Muscle Atrophy
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