ESPL1 and TRAFD1

		ESPL1	TRAFD1
Description		extra spindle pole bodies like 1, separase	TRAF-type zinc finger domain containing 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Cytosol Mitotic Spindle	Mitochondrion
	Molecular Function	Catalytic Activity Cysteine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity	Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Mitotic Sister Chromatid Segregation Meiotic Spindle Organization Mitotic Cell Cycle Nuclear Division Mitotic Cytokinesis Proteolysis Apoptotic Process Chromosome Segregation Meiosis I Establishment Of Mitotic Spindle Localization Homologous Chromosome Segregation Positive Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Sister Chromatid Cohesion Mitotic Sister Chromatid Separation Meiotic Chromosome Separation Nuclear Chromosome Segregation	Negative Regulation Of Innate Immune Response
Pathways		Separation of Sister Chromatids
Drugs
Diseases
GWAS		Femoral neck bone mineral density ( 29499414) Lumbar spine bone mineral density ( 29499414)	Alanine aminotransferase levels ( 30718733) Alcohol consumption (max-drinks) ( 29460428) Alcohol dependence symptom count ( 29460428) Aspartate aminotransferase levels ( 30718733) Body mass index ( 25673413 26426971) Coffee consumption ( 29367735) Confectionary intake ( 33632354) Hemoglobin ( 19862010) Hemoglobin levels ( 32327693) Neutrophil count ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494) Primary biliary cholangitis ( 26394269) Response to alcohol consumption (flushing response) ( 29460428) Spleen volume ( 34128465) Systemic lupus erythematosus ( 28714469) Type 1 diabetes ( 17554300) White blood cell count ( 32888494)
Interacting Genes		7 interacting genes: MTNR1B PJA1 RFFL TRIM55 TRIM63 USP21 USP28	5 interacting genes: CFTR HTT NGLY1 TRAF6 UBC
Entrez ID		9700	10906
HPRD ID		06825	10994
Ensembl ID		ENSG00000135476	ENSG00000135148
Uniprot IDs		Q14674	O14545
PDB IDs		7NJ0 7NJ1	2D9K
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Ubiquitin Protein Ligase Activity Protein Modification Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Metabolic Process Zinc Ion Binding Cysteine-type Deubiquitinase Activity Protein Deubiquitination Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Protein K48-linked Ubiquitination Protein Modification By Small Protein Removal Metal Ion Binding Cysteine-type Peptidase Activity Melatonin Receptor Activity Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Positive Regulation Of Transmission Of Nerve Impulse Positive Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of CGMP-mediated Signaling Regulation Of Neuronal Action Potential Negative Regulation Of Transmission Of Nerve Impulse Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep DeNEDDylase Activity Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Diapedesis Skeletal Muscle Atrophy Skeletal Muscle Adaptation Striated Muscle Atrophy	Positive Regulation Of Ion Transmembrane Transporter Activity Positive Regulation Of Transporter Activity Odontogenesis Of Dentin-containing Tooth Endosome Membrane Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Establishment Of Spindle Localization Establishment Of Mitotic Spindle Localization Spindle Localization Peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine Amidase Activity
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