ESPL1

Description		extra spindle pole bodies like 1, separase
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GO Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Cytosol Mitotic Spindle
	Molecular Function	Catalytic Activity Cysteine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity
	Biological Process	Mitotic Sister Chromatid Segregation Meiotic Spindle Organization Mitotic Cell Cycle Nuclear Division Mitotic Cytokinesis Proteolysis Apoptotic Process Chromosome Segregation Meiosis I Establishment Of Mitotic Spindle Localization Homologous Chromosome Segregation Positive Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Sister Chromatid Cohesion Mitotic Sister Chromatid Separation Meiotic Chromosome Separation Nuclear Chromosome Segregation
Pathways		Separation of Sister Chromatids
Drugs
Diseases
GWAS		Femoral neck bone mineral density ( 29499414) Lumbar spine bone mineral density ( 29499414)
Novel Interacting Genes		8 novel interacting genes: MTNR1B PJA1 RFFL TRAFD1 TRIM55 TRIM63 USP21 USP28
Interacting Genes		8 interacting genes: MTNR1B PJA1 RFFL TRAFD1 TRIM55 TRIM63 USP21 USP28
Entrez ID		9700
HPRD ID		06825
Ensembl ID		ENSG00000135476
Uniprot IDs		Q14674
PDB IDs		7NJ0 7NJ1
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Ubiquitin Protein Ligase Activity Protein Modification Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Metabolic Process Zinc Ion Binding Cysteine-type Deubiquitinase Activity Protein Deubiquitination Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Protein K48-linked Ubiquitination Protein Modification By Small Protein Removal Metal Ion Binding Cysteine-type Peptidase Activity Melatonin Receptor Activity Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Positive Regulation Of Transmission Of Nerve Impulse Positive Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of CGMP-mediated Signaling Regulation Of Neuronal Action Potential Negative Regulation Of Transmission Of Nerve Impulse Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep DeNEDDylase Activity Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Diapedesis Skeletal Muscle Atrophy Skeletal Muscle Adaptation Striated Muscle Atrophy
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