TRAFD1 and KCNMB4

		TRAFD1	KCNMB4
Description		TRAF-type zinc finger domain containing 1	potassium calcium-activated channel subfamily M regulatory beta subunit 4
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GO Annotations	Cellular Component	Mitochondrion	Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Synapse
	Molecular Function	Protein Binding Zinc Ion Binding Metal Ion Binding	Protein Binding Calcium-activated Potassium Channel Activity Potassium Channel Regulator Activity Voltage-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential
	Biological Process	Negative Regulation Of Innate Immune Response	Action Potential Detection Of Calcium Ion Monoatomic Ion Transport Potassium Ion Transport Chemical Synaptic Transmission Neuronal Action Potential Regulation Of Vasoconstriction Monoatomic Ion Transmembrane Transport Regulation Of Neurotransmitter Secretion Potassium Ion Transmembrane Transport Regulation Of Presynaptic Membrane Potential
Pathways			Ca2+ activated K+ channels cGMP effects
Drugs			Procaine Ritodrine Nitrendipine Miconazole Colforsin Trimebutine
Diseases
GWAS		Alanine aminotransferase levels ( 30718733) Alcohol consumption (max-drinks) ( 29460428) Alcohol dependence symptom count ( 29460428) Aspartate aminotransferase levels ( 30718733) Body mass index ( 25673413 26426971) Coffee consumption ( 29367735) Confectionary intake ( 33632354) Hemoglobin ( 19862010) Hemoglobin levels ( 32327693) Neutrophil count ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494) Primary biliary cholangitis ( 26394269) Response to alcohol consumption (flushing response) ( 29460428) Spleen volume ( 34128465) Systemic lupus erythematosus ( 28714469) Type 1 diabetes ( 17554300) White blood cell count ( 32888494)	Appendicular lean mass ( 33097823) Gut microbiota relative abundance (unassigned genus belonging to family Clostridiales) ( 33208821) L1-L4 bone mineral density x serum urate levels interaction ( 34046847) Metabolite levels ( 23823483)
Interacting Genes		9 interacting genes: CFTR ESPL1 HTT KCNMB4 NGLY1 PRPF40B PTPRD TRAF6 UBC	5 interacting genes: CSDE1 MAL MS4A13 SNCA TRAFD1
Entrez ID		10906	27345
HPRD ID		10994	05564
Ensembl ID		ENSG00000135148	ENSG00000135643
Uniprot IDs		O14545	Q86W47
PDB IDs		2D9K	5Y7L 6V22 6V35 9CZH 9CZJ 9CZK 9CZM 9CZO 9CZQ 9D18 9D19
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Ion Transmembrane Transporter Activity Positive Regulation Of Transporter Activity Odontogenesis Of Dentin-containing Tooth Endosome Membrane Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Establishment Of Spindle Localization Establishment Of Mitotic Spindle Localization Spindle Localization Peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine Amidase Activity	Protein Insertion Into Plasma Membrane Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Protein Localization To Paranode Region Of Axon Membrane Raft Polarization Peptidase Activator Activity Involved In Apoptotic Process Negative Regulation Of Dopamine Metabolic Process Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Negative Regulation Of Catecholamine Metabolic Process Negative Regulation Of Chaperone-mediated Autophagy Regulation Of Serotonin Uptake MCRD-mediated MRNA Stability Complex RISC Complex Binding Dopamine Uptake Involved In Synaptic Transmission Nuclear-transcribed MRNA Catabolic Process, No-go Decay CRD-mediated MRNA Stability Complex Membrane Raft Distribution Response To Iron(II) Ion Membrane Raft Localization Regulation Of Chaperone-mediated Autophagy Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Oxidative Phosphorylation Protein Localization To Axon Schmidt-Lanterman Incisure Structural Constituent Of Myelin Sheath Mitochondrial ATP Synthesis Coupled Electron Transport Cuprous Ion Binding Catecholamine Uptake Dopamine Uptake Dopamine Biosynthetic Process Regulation Of Acyl-CoA Biosynthetic Process Positive Regulation Of Inositol Phosphate Biosynthetic Process Negative Regulation Of Cellular Respiration Supramolecular Fiber IRES-dependent Viral Translational Initiation CRD-mediated MRNA Stabilization Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors SNARE Complex Assembly Cellular Response To Epinephrine Stimulus Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Lipid Binding
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