CNKSR1 and PPFIA3

Number of citations of the paper that reports this interaction (PubMedID 34187934)
69

Data Source:
BioGRID (pull down)

		CNKSR1	PPFIA3
Description		connector enhancer of kinase suppressor of Ras 1	PPFI scaffold protein A3
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Cell-cell Junction Cell Cortex Membrane	Acrosomal Vesicle Cytoplasm Cytosol Cytoplasmic Vesicle Synapse Presynaptic Active Zone Presynaptic Active Zone Cytoplasmic Component Epididymosome Glutamatergic Synapse
	Molecular Function	Protein Binding Protein-macromolecule Adaptor Activity	Protein Binding
	Biological Process	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway	Neurotransmitter Secretion Synaptic Vesicle Exocytosis Synaptic Vesicle Docking Regulation Of Short-term Neuronal Synaptic Plasticity Synapse Organization
Pathways		MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants	Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Receptor-type tyrosine-protein phosphatases
Drugs
Diseases
GWAS		Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189)	Adult body size ( 32376654) Leukoderma in response to rhododendrol ( 32558222)
Interacting Genes		37 interacting genes: ARHGEF1 BRAP CADM4 CYTH3 CYTH4 DSCR9 DUSP10 DUSP7 ENPP3 G6PC3 ILKAP MAP2K2 MAP2K7 MAP3K10 PIN1 PPFIA1 PPFIA3 PPP1R14C PPP1R8 PTPN18 PTPN6 PTPRH PTPRJ PTPRM PTPRR RAF1 RALGDS RASSF1 RHOA RHPN1 SASH1 SMAD4 STK3 STK4 TCAF1 ZDHHC17 ZGPAT	18 interacting genes: ATP1A3 CAST CBY2 CNKSR1 DISC1 ERC2 GIT1 PPFIA1 PPFIA2 PPFIBP1 PPFIBP2 PPP1R13B PTPRD PTPRF PTPRS PTPRU SORBS3 TFIP11
Entrez ID		10256	8541
HPRD ID		11937	04393
Ensembl ID		ENSG00000142675	ENSG00000177380
Uniprot IDs		B4DL25 G3V160 Q53GM7 Q969H4	O75145
PDB IDs		1WWV
Enriched GO Terms of Interacting Partners?		Regulation Of MAPK Cascade Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity MAPK Cascade Intracellular Signaling Cassette Regulation Of Protein Phosphorylation Regulation Of Intracellular Signal Transduction Regulation Of Phosphorylation Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of Protein Modification Process Dephosphorylation Regulation Of Phosphorus Metabolic Process Protein Dephosphorylation Transmembrane Receptor Protein Tyrosine Phosphatase Activity Negative Regulation Of MAPK Cascade Negative Regulation Of Signal Transduction Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Protein Serine/threonine Kinase Activity Intracellular Signal Transduction Phosphate-containing Compound Metabolic Process Protein Modification Process Positive Regulation Of Protein Phosphorylation Negative Regulation Of ERK1 And ERK2 Cascade Regulation Of Protein Kinase Activity Positive Regulation Of Phosphorylation Regulation Of Kinase Activity Positive Regulation Of Protein Modification Process Signal Transduction Positive Regulation Of Phosphate Metabolic Process Regulation Of Cell Motility Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Cell Motility Regulation Of Protein Metabolic Process Negative Regulation Of Locomotion Regulation Of Locomotion Regulation Of MAP Kinase Activity Peptidyl-tyrosine Dephosphorylation ERBB2 Signaling Pathway Hydrolase Activity Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Population Proliferation Small GTPase-mediated Signal Transduction Negative Regulation Of Mast Cell Activation Involved In Immune Response Primitive Hemopoiesis Anatomical Structure Formation Involved In Morphogenesis Negative Regulation Of ERBB Signaling Pathway	Presynaptic Active Zone Synapse Organization Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Regulation Of Dendritic Spine Development Cell Junction Organization Transmembrane Receptor Protein Tyrosine Phosphatase Activity Cell Adhesion Synaptic Membrane Adhesion Protein Tyrosine Phosphatase Activity Maintenance Of Synapse Structure Presynaptic Membrane Phosphoprotein Phosphatase Activity Regulation Of Postsynapse Organization Glutamatergic Synapse Cell Junction Maintenance Cortical Microtubule Organization Axon Presynaptic Active Zone Organization Cellular Component Maintenance Maintenance Of Postsynaptic Specialization Structure Regulation Of Cellular Component Organization Regulation Of Neuron Projection Development Presynapse Protein Dephosphorylation Regulation Of Postsynaptic Density Assembly Modulation Of Chemical Synaptic Transmission Postsynaptic Density Schaffer Collateral - CA1 Synapse GABA-ergic Synapse Presynapse Organization Postsynaptic Density Organization Regulation Of Postsynaptic Specialization Assembly Regulation Of Excitatory Synapse Assembly Peptidyl-tyrosine Dephosphorylation Regulation Of Synapse Organization Synapse Postsynaptic Specialization Organization Dephosphorylation Regulation Of Axon Regeneration Growth Cone Regulation Of Neuron Projection Regeneration Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Cell-substrate Adhesion Neuromuscular Junction Development Regulation Of Response To Wounding Cell Cortex Focal Adhesion Regulation Of Dendritic Spine Morphogenesis
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