CNKSR1 and ARHGEF1

Number of citations of the paper that reports this interaction (PubMedID 15753034)
0

Data Source:
HPRD (in vivo)

		CNKSR1	ARHGEF1
Description		connector enhancer of kinase suppressor of Ras 1	Rho guanine nucleotide exchange factor 1
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GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Cell-cell Junction Cell Cortex Membrane	Cytoplasm Cytosol Plasma Membrane Membrane
	Molecular Function	Protein Binding Protein-macromolecule Adaptor Activity	G Protein-coupled Receptor Binding RNA Binding Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding
	Biological Process	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway	G Protein-coupled Receptor Signaling Pathway Rho Protein Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Rho-activating G Protein-coupled Receptor Signaling Pathway
Pathways		MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants	NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle
Drugs
Diseases
GWAS		Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189)	Brain morphology (MOSTest) ( 32665545) Hallux valgus ( 32131869)
Interacting Genes		37 interacting genes: ARHGEF1 BRAP CADM4 CYTH3 CYTH4 DSCR9 DUSP10 DUSP7 ENPP3 G6PC3 ILKAP MAP2K2 MAP2K7 MAP3K10 PIN1 PPFIA1 PPFIA3 PPP1R14C PPP1R8 PTPN18 PTPN6 PTPRH PTPRJ PTPRM PTPRR RAF1 RALGDS RASSF1 RHOA RHPN1 SASH1 SMAD4 STK3 STK4 TCAF1 ZDHHC17 ZGPAT	12 interacting genes: ATR CD44 CNKSR1 CSNK1E GNA13 HRAS PRKCA RAP1A RHOA RNF10 SREBF2 TCF4
Entrez ID		10256	9138
HPRD ID		11937	03511
Ensembl ID		ENSG00000142675	ENSG00000076928
Uniprot IDs		B4DL25 G3V160 Q53GM7 Q969H4	M0QZR4 Q92888
PDB IDs		1WWV	1IAP 1SHZ 3AB3 3ODO 3ODW 3ODX 3P6A
Enriched GO Terms of Interacting Partners?		Regulation Of MAPK Cascade Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity MAPK Cascade Intracellular Signaling Cassette Regulation Of Protein Phosphorylation Regulation Of Intracellular Signal Transduction Regulation Of Phosphorylation Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of Protein Modification Process Dephosphorylation Regulation Of Phosphorus Metabolic Process Protein Dephosphorylation Transmembrane Receptor Protein Tyrosine Phosphatase Activity Negative Regulation Of MAPK Cascade Negative Regulation Of Signal Transduction Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Protein Serine/threonine Kinase Activity Intracellular Signal Transduction Phosphate-containing Compound Metabolic Process Protein Modification Process Positive Regulation Of Protein Phosphorylation Negative Regulation Of ERK1 And ERK2 Cascade Regulation Of Protein Kinase Activity Positive Regulation Of Phosphorylation Regulation Of Kinase Activity Positive Regulation Of Protein Modification Process Signal Transduction Positive Regulation Of Phosphate Metabolic Process Regulation Of Cell Motility Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Cell Motility Regulation Of Protein Metabolic Process Negative Regulation Of Locomotion Regulation Of Locomotion Regulation Of MAP Kinase Activity Peptidyl-tyrosine Dephosphorylation ERBB2 Signaling Pathway Hydrolase Activity Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Population Proliferation Small GTPase-mediated Signal Transduction Negative Regulation Of Mast Cell Activation Involved In Immune Response Primitive Hemopoiesis Anatomical Structure Formation Involved In Morphogenesis Negative Regulation Of ERBB Signaling Pathway	G Protein Activity Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Intracellular Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Cell Junction Assembly Intracellular Signal Transduction Positive Regulation Of Cell Communication Regulation Of Signal Transduction Small GTPase-mediated Signal Transduction Positive Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Nucleotide Binding Positive Regulation Of Signal Transduction GTPase Activity Regulation Of Cell Communication Regulation Of Signaling Membrane Disassembly Nuclear Membrane Disassembly Regulation Of ERK1 And ERK2 Cascade Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane GTP Binding Intracellular Signaling Cassette Wound Healing, Spreading Of Cells Cellular Response To Gamma Radiation Regulation Of Receptor Localization To Synapse Regulation Of Protein Localization To Synapse Positive Regulation Of MAPK Cascade Regulation Of Protein Localization Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Cellular Component Biogenesis Cellular Response To Nerve Growth Factor Stimulus Regulation Of Developmental Process Glutamatergic Synapse Response To Nerve Growth Factor Regulation Of Cellular Component Organization Nuclear Membrane Organization Non-canonical Wnt Signaling Pathway Response To Gamma Radiation Positive Regulation Of Cellular Component Organization Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Mitotic Cleavage Furrow Formation E-box Binding Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of MAPK Cascade Cellular Response To Growth Factor Stimulus Regulation Of Cell Projection Organization Positive Regulation Of MiRNA Metabolic Process Rho Protein Signal Transduction
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