PPFIA3 and CAST

Number of citations of the paper that reports this interaction (PubMedID 12923177)
0

Data Source:
HPRD (two hybrid, in vitro)

		PPFIA3	CAST
Description		PPFI scaffold protein A3	calpastatin
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Cytoplasm Cytosol Cytoplasmic Vesicle Synapse Presynaptic Active Zone Presynaptic Active Zone Cytoplasmic Component Epididymosome Glutamatergic Synapse	Cytoplasm Endoplasmic Reticulum Cytosol Membrane
	Molecular Function	Protein Binding	RNA Binding Endopeptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding Calcium-dependent Cysteine-type Endopeptidase Inhibitor Activity Peptidase Inhibitor Activity Cadherin Binding
	Biological Process	Neurotransmitter Secretion Synaptic Vesicle Exocytosis Synaptic Vesicle Docking Regulation Of Short-term Neuronal Synaptic Plasticity Synapse Organization	Presynaptic Active Zone Organization Negative Regulation Of Type B Pancreatic Cell Apoptotic Process
Pathways		Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Receptor-type tyrosine-protein phosphatases	Degradation of the extracellular matrix Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Drugs			Calcium Artenimol
Diseases
GWAS		Adult body size ( 32376654) Leukoderma in response to rhododendrol ( 32558222)	Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Alcohol dependence ( 19581569) Appendicular lean mass ( 33097823) Body mass index ( 26426971 29381148) Fish- and plant-related diet ( 32066663) Medication use (agents acting on the renin-angiotensin system) ( 31015401)
Interacting Genes		18 interacting genes: ATP1A3 CAST CBY2 CNKSR1 DISC1 ERC2 GIT1 PPFIA1 PPFIA2 PPFIBP1 PPFIBP2 PPP1R13B PTPRD PTPRF PTPRS PTPRU SORBS3 TFIP11	11 interacting genes: CAPN1 CAPNS1 CASP1 CASP3 CASP7 HTRA1 PPFIA1 PPFIA2 PPFIA3 PPFIA4 SUMO2
Entrez ID		8541	831
HPRD ID		04393	00233
Ensembl ID		ENSG00000177380	ENSG00000310517
Uniprot IDs		O75145	A0A6Q8PH20 B7Z6N0 E9PCH5 E9PDE4 P20810 Q59HE3 Q86YM9
PDB IDs
Enriched GO Terms of Interacting Partners?		Presynaptic Active Zone Synapse Organization Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Regulation Of Dendritic Spine Development Cell Junction Organization Transmembrane Receptor Protein Tyrosine Phosphatase Activity Cell Adhesion Synaptic Membrane Adhesion Protein Tyrosine Phosphatase Activity Maintenance Of Synapse Structure Presynaptic Membrane Phosphoprotein Phosphatase Activity Regulation Of Postsynapse Organization Glutamatergic Synapse Cell Junction Maintenance Cortical Microtubule Organization Axon Presynaptic Active Zone Organization Cellular Component Maintenance Maintenance Of Postsynaptic Specialization Structure Regulation Of Cellular Component Organization Regulation Of Neuron Projection Development Presynapse Protein Dephosphorylation Regulation Of Postsynaptic Density Assembly Modulation Of Chemical Synaptic Transmission Postsynaptic Density Schaffer Collateral - CA1 Synapse GABA-ergic Synapse Presynapse Organization Postsynaptic Density Organization Regulation Of Postsynaptic Specialization Assembly Regulation Of Excitatory Synapse Assembly Peptidyl-tyrosine Dephosphorylation Regulation Of Synapse Organization Synapse Postsynaptic Specialization Organization Dephosphorylation Regulation Of Axon Regeneration Growth Cone Regulation Of Neuron Projection Regeneration Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Cell-substrate Adhesion Neuromuscular Junction Development Regulation Of Response To Wounding Cell Cortex Focal Adhesion Regulation Of Dendritic Spine Morphogenesis	Presynaptic Active Zone Protein Poly-ADP-ribosylation Calpain Complex Cysteine-type Peptidase Activity Pyroptotic Inflammatory Response Cellular Response To Staurosporine Peptidase Activity Cysteine-type Endopeptidase Activity Synapse Organization Calcium-dependent Cysteine-type Endopeptidase Activity Fibroblast Apoptotic Process Proteolysis Interleukin-18-mediated Signaling Pathway Cytosol Aspartic-type Endopeptidase Activity Execution Phase Of Apoptosis Plasma Membrane Repair Cell Junction Organization Protein Processing Regulation Of Macroautophagy Cellular Response To Alkaloid Glutamatergic Synapse Cellular Response To Osmotic Stress Leukocyte Apoptotic Process Ceramide Biosynthetic Process Structural Constituent Of Presynapse Epididymosome Protein Metabolic Process Cytoplasm Protein Maturation Response To Lipopolysaccharide Positive Regulation Of Neuron Apoptotic Process Striated Muscle Cell Differentiation Response To Osmotic Stress Response To Molecule Of Bacterial Origin AIM2 Inflammasome Complex Assembly Protease Inhibitor Complex Phospholipase A2 Activator Activity Regulation Of Autophagy Ceramide Metabolic Process Post-translational Protein Modification Endopeptidase Activity Response To Alkaloid Sphingolipid Biosynthetic Process AIM2 Inflammasome Complex IPAF Inflammasome Complex Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Structural Constituent Of Postsynaptic Density Hydrolase Activity Cell Death
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