CNKSR1 and RHPN1

Number of citations of the paper that reports this interaction (PubMedID 14749388)
44

Data Source:
HPRD (in vitro, in vivo)

		CNKSR1	RHPN1
Description		connector enhancer of kinase suppressor of Ras 1	rhophilin Rho GTPase binding protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Cell-cell Junction Cell Cortex Membrane	Cytosol
	Molecular Function	Protein Binding Protein-macromolecule Adaptor Activity	Protein Binding
	Biological Process	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway	Signal Transduction Negative Regulation Of Stress Fiber Assembly
Pathways		MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants	RHO GTPases Activate Rhotekin and Rhophilins RHO GTPases Activate Rhotekin and Rhophilins RHOA GTPase cycle
Drugs
Diseases
GWAS		Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189)
Interacting Genes		37 interacting genes: ARHGEF1 BRAP CADM4 CYTH3 CYTH4 DSCR9 DUSP10 DUSP7 ENPP3 G6PC3 ILKAP MAP2K2 MAP2K7 MAP3K10 PIN1 PPFIA1 PPFIA3 PPP1R14C PPP1R8 PTPN18 PTPN6 PTPRH PTPRJ PTPRM PTPRR RAF1 RALGDS RASSF1 RHOA RHPN1 SASH1 SMAD4 STK3 STK4 TCAF1 ZDHHC17 ZGPAT	16 interacting genes: CALCOCO2 CEP70 CNKSR1 EFEMP2 GPRASP2 HAP1 KRT15 KRT31 LZTS1 MTUS2 RHOA ROPN1 TRIM27 TRIM37 TRIM55 TRIM63
Entrez ID		10256	114822
HPRD ID		11937	17973
Ensembl ID		ENSG00000142675	ENSG00000158106
Uniprot IDs		B4DL25 G3V160 Q53GM7 Q969H4	Q8TCX5
PDB IDs		1WWV
Enriched GO Terms of Interacting Partners?		Regulation Of MAPK Cascade Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity MAPK Cascade Intracellular Signaling Cassette Regulation Of Protein Phosphorylation Regulation Of Intracellular Signal Transduction Regulation Of Phosphorylation Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of Protein Modification Process Dephosphorylation Regulation Of Phosphorus Metabolic Process Protein Dephosphorylation Transmembrane Receptor Protein Tyrosine Phosphatase Activity Negative Regulation Of MAPK Cascade Negative Regulation Of Signal Transduction Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Protein Serine/threonine Kinase Activity Intracellular Signal Transduction Phosphate-containing Compound Metabolic Process Protein Modification Process Positive Regulation Of Protein Phosphorylation Negative Regulation Of ERK1 And ERK2 Cascade Regulation Of Protein Kinase Activity Positive Regulation Of Phosphorylation Regulation Of Kinase Activity Positive Regulation Of Protein Modification Process Signal Transduction Positive Regulation Of Phosphate Metabolic Process Regulation Of Cell Motility Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Cell Motility Regulation Of Protein Metabolic Process Negative Regulation Of Locomotion Regulation Of Locomotion Regulation Of MAP Kinase Activity Peptidyl-tyrosine Dephosphorylation ERBB2 Signaling Pathway Hydrolase Activity Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Population Proliferation Small GTPase-mediated Signal Transduction Negative Regulation Of Mast Cell Activation Involved In Immune Response Primitive Hemopoiesis Anatomical Structure Formation Involved In Morphogenesis Negative Regulation Of ERBB Signaling Pathway	Regulation Of Microtubule-based Process Supramolecular Fiber Organization Cytoskeleton Myosin Binding Ubiquitin Protein Ligase Activity
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