PSME3 and PKD1L1

		PSME3	PKD1L1
Description		proteasome activator subunit 3	polycystin 1 like 1, transient receptor potential channel interacting
Image			No pdb structure
GO Annotations	Cellular Component	Proteasome Complex Nucleus Nucleoplasm Cytoplasm Cytosol Cilium Proteasome Activator Complex Membrane Ciliary Basal Body	Plasma Membrane Cilium Membrane Calcium Channel Complex Cell Projection Ciliary Membrane Non-motile Cilium
	Molecular Function	P53 Binding Protein Binding Identical Protein Binding Endopeptidase Activator Activity MDM2/MDM4 Family Protein Binding	Calcium Channel Activity Protein Binding
	Biological Process	Apoptotic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Detection Of Nodal Flow Monoatomic Ion Transport Calcium Ion Transport Monoatomic Ion Transmembrane Transport Detection Of Mechanical Stimulus Calcium Ion Transmembrane Transport Left/right Axis Specification Cell-cell Adhesion
Pathways		Proteasome assembly
Drugs
Diseases
GWAS			Anxiety disorder ( 25390645) Diastolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415) Gut microbiota alpha diversity (Shannon index) ( 33208821) Hepatitis C induced liver fibrosis ( 22841784) Obstructive sleep apnea during REM sleep (apnea hypopnea index) ( 29077507) Refractive error ( 32231278) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		66 interacting genes: ABCF3 ADAP1 AICDA ATN1 ATP5F1B BBS2 CASP3 CASP6 CASP7 CDC25B CDC42 CEBPA CHEK2 COIL CREBBP DEPTOR DIP2A DMRT3 DTNBP1 DVL3 EAF1 EAF2 FAM90A1 FBXL12 FMR1 FOXD4L1 FXR1 FXR2 GPATCH2L HDAC5 HSPA5 IKZF3 INPP5J ITPKB KANSL1 KBTBD7 KLF2 LNX1 MDM2 MEOX2 NCOA3 NTAQ1 NUDT18 PFDN5 PICK1 PKD1L1 PRKAB2 PRR13 RDX RNF111 RPH3AL RPS27 SERF2 SIRT1 SMURF1 SPG7 TBXA2R THAP10 TNFAIP8L1 TP53 TXN2 UBE2H UBE2I WDR25 YWHAQ ZCCHC10	11 interacting genes: ABCA13 ABCC3 ACAA2 C7orf57 CLK1 LINC02902 MGAT2 PKD1L1-AS1 PLCB2 PSME3 RPL6
Entrez ID		10197	168507
HPRD ID		05500	10154
Ensembl ID		ENSG00000131467	ENSG00000158683
Uniprot IDs		B3KQ25 P61289 V9HWJ8	Q8TDX9
PDB IDs		7YQC 7YQD
Enriched GO Terms of Interacting Partners?		Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Cellular Response To Staurosporine Response To Nutrient Levels Protein Binding Protein Domain Specific Binding Nucleus Positive Regulation Of Long-term Neuronal Synaptic Plasticity Cellular Response To Nutrient Levels Macromolecule Catabolic Process Cytosol Positive Regulation Of Protein Metabolic Process Cellular Response To Alkaloid Post-translational Protein Modification Response To Xenobiotic Stimulus Neuron Projection Response To Alkaloid Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Leukocyte Apoptotic Process Response To UV Proteolysis Regulation Of Protein Metabolic Process Signal Transduction By P53 Class Mediator Mononuclear Cell Differentiation Protein-containing Complex Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Translation Regulator Activity Cellular Response To Glucose Starvation Cellular Response To Actinomycin D Positive Regulation Of Catabolic Process Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cytoplasm Developmental Process Modification-dependent Protein Catabolic Process PML Body Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of RNA Metabolic Process Protein Destabilization Response To Actinomycin D HLH Domain Binding Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Protein Stability Leukocyte Differentiation Protein Catabolic Process Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of MiRNA-mediated Gene Silencing Disordered Domain Specific Binding Glial Cell Apoptotic Process Positive Regulation Of Macromolecule Biosynthetic Process	Alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase Activity G-protein Beta/gamma-subunit Complex ATPase-coupled Transmembrane Transporter Activity Icosanoid Transmembrane Transporter Activity ABC-type Transporter Activity Glucuronoside Transmembrane Transporter Activity Glucuronoside Transport Ciliary Basal Body
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