PSME3 and NUDT18

Number of citations of the paper that reports this interaction (PubMedID 16189514)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PSME3	NUDT18
Description		proteasome activator subunit 3	nudix hydrolase 18
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GO Annotations	Cellular Component	Proteasome Complex Nucleus Nucleoplasm Cytoplasm Cytosol Cilium Proteasome Activator Complex Membrane Ciliary Basal Body	Cytosol
	Molecular Function	P53 Binding Protein Binding Identical Protein Binding Endopeptidase Activator Activity MDM2/MDM4 Family Protein Binding	Protein Binding Hydrolase Activity Nucleoside Diphosphate Phosphatase Activity 8-oxo-dGDP Phosphatase Activity 8-oxo-GDP Phosphatase Activity 8-hydroxy-dADP Phosphatase Activity Metal Ion Binding
	Biological Process	Apoptotic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Nucleotide Metabolic Process DADP Catabolic Process DGDP Catabolic Process GDP Catabolic Process Nucleobase-containing Small Molecule Metabolic Process
Pathways		Proteasome assembly
Drugs
Diseases
GWAS
Interacting Genes		66 interacting genes: ABCF3 ADAP1 AICDA ATN1 ATP5F1B BBS2 CASP3 CASP6 CASP7 CDC25B CDC42 CEBPA CHEK2 COIL CREBBP DEPTOR DIP2A DMRT3 DTNBP1 DVL3 EAF1 EAF2 FAM90A1 FBXL12 FMR1 FOXD4L1 FXR1 FXR2 GPATCH2L HDAC5 HSPA5 IKZF3 INPP5J ITPKB KANSL1 KBTBD7 KLF2 LNX1 MDM2 MEOX2 NCOA3 NTAQ1 NUDT18 PFDN5 PICK1 PKD1L1 PRKAB2 PRR13 RDX RNF111 RPH3AL RPS27 SERF2 SIRT1 SMURF1 SPG7 TBXA2R THAP10 TNFAIP8L1 TP53 TXN2 UBE2H UBE2I WDR25 YWHAQ ZCCHC10	34 interacting genes: APIP CAVIN2 COIL CUTC DCTD DHPS DUT EVI5L GLUL GNMT GSE1 HSD17B14 KCTD13 KCTD17 KHDRBS3 KRT15 KRTAP4-12 KXD1 NADK NAT9 NT5C2 PAICS PCBD1 PSME3 RAB3IL1 RABAC1 RAD54B RWDD1 TARBP2 TERF2IP TIFA TRAF2 TRIM37 ZBED1
Entrez ID		10197	79873
HPRD ID		05500	07992
Ensembl ID		ENSG00000131467	ENSG00000275074
Uniprot IDs		B3KQ25 P61289 V9HWJ8	Q6ZVK8
PDB IDs		7YQC 7YQD	3GG6 4HVY
Enriched GO Terms of Interacting Partners?		Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Cellular Response To Staurosporine Response To Nutrient Levels Protein Binding Protein Domain Specific Binding Nucleus Positive Regulation Of Long-term Neuronal Synaptic Plasticity Cellular Response To Nutrient Levels Macromolecule Catabolic Process Cytosol Positive Regulation Of Protein Metabolic Process Cellular Response To Alkaloid Post-translational Protein Modification Response To Xenobiotic Stimulus Neuron Projection Response To Alkaloid Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Leukocyte Apoptotic Process Response To UV Proteolysis Regulation Of Protein Metabolic Process Signal Transduction By P53 Class Mediator Mononuclear Cell Differentiation Protein-containing Complex Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Translation Regulator Activity Cellular Response To Glucose Starvation Cellular Response To Actinomycin D Positive Regulation Of Catabolic Process Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cytoplasm Developmental Process Modification-dependent Protein Catabolic Process PML Body Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of RNA Metabolic Process Protein Destabilization Response To Actinomycin D HLH Domain Binding Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Protein Stability Leukocyte Differentiation Protein Catabolic Process Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of MiRNA-mediated Gene Silencing Disordered Domain Specific Binding Glial Cell Apoptotic Process Positive Regulation Of Macromolecule Biosynthetic Process	Identical Protein Binding DUMP Biosynthetic Process DTMP Biosynthetic Process Pyrimidine Deoxyribonucleoside Monophosphate Biosynthetic Process Nucleoside Monophosphate Metabolic Process Negative Regulation Of Defense Response To Virus By Host Protein Complex Oligomerization Protein Homooligomerization Pyrimidine Deoxyribonucleotide Biosynthetic Process Nucleoside Monophosphate Biosynthetic Process Deoxyribonucleotide Metabolic Process Cytosol Nucleoside Metabolic Process Deoxyribonucleoside Monophosphate Biosynthetic Process Protein Binding Amino Acid Biosynthetic Process L-amino Acid Metabolic Process Small Molecule Metabolic Process Deoxyribonucleotide Biosynthetic Process 2'-deoxyribonucleotide Biosynthetic Process Methionine Metabolic Process Negative Regulation Of Defense Response To Virus Alpha-amino Acid Metabolic Process Protein-containing Complex Assembly IMP Metabolic Process Nucleotide Biosynthetic Process Purine Nucleobase Metabolic Process Protein Tetramerization Nucleobase-containing Small Molecule Metabolic Process Nucleotide Metabolic Process Purine Nucleoside Metabolic Process Pyrimidine Nucleotide Biosynthetic Process Deoxyhypusine Synthase Activity Deoxyribose Phosphate Catabolic Process Deoxyribonucleotide Catabolic Process DUTP Catabolic Process DUTP Diphosphatase Activity Amino Acid Metabolic Process Intracellular Ammonium Homeostasis Tumor Necrosis Factor Receptor Binding Regulation Of SiRNA Processing Protein-containing Complex Organization TORC2 Complex Disassembly Protein Autosumoylation Phosphoribosylaminoimidazolesuccinocarboxamide Synthase Activity GMP Metabolic Process Phosphoribosylaminoimidazole Carboxylase Activity Nucleoside Phosphotransferase Activity GMP Catabolic Process To Guanine Tubulin N-terminal-methionine Acetyltransferase Activity
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