PSME3 and AICDA

Number of citations of the paper that reports this interaction (PubMedID 22042974)
27

Data Source:
BioGRID (affinity chromatography technology, pull down)

		PSME3	AICDA
Description		proteasome activator subunit 3	activation induced cytidine deaminase
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GO Annotations	Cellular Component	Proteasome Complex Nucleus Nucleoplasm Cytoplasm Cytosol Cilium Proteasome Activator Complex Membrane Ciliary Basal Body	P-body Nucleus Cytoplasm Cytosol Protein-containing Complex
	Molecular Function	P53 Binding Protein Binding Identical Protein Binding Endopeptidase Activator Activity MDM2/MDM4 Family Protein Binding	RNA Binding Catalytic Activity Cytidine Deaminase Activity Protein Binding Zinc Ion Binding Hydrolase Activity Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Cyclic Amidines Ubiquitin Protein Ligase Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Apoptotic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	MRNA Processing Regulation Of Macromolecule Biosynthetic Process Somatic Diversification Of Immunoglobulins Somatic Hypermutation Of Immunoglobulin Genes Cytidine To Uridine Editing B Cell Differentiation Regulation Of Nuclear Cell Cycle DNA Replication Defense Response To Bacterium Positive Regulation Of Gene Expression Via Chromosomal CpG Island Demethylation Isotype Switching Negative Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Defense Response To Virus DNA Cytosine Deamination Cellular Response To Lipopolysaccharide
Pathways		Proteasome assembly	Chromatin modifications during the maternal to zygotic transition (MZT)
Drugs
Diseases			Hyper IgM syndromes, autosomal recessive type, including the following three diseases: Activation-induced cytidine deaminase (AICD) defect; Uracil nucleotide glycoside glycosylase (UNG) defect; Immunodeficiency with hyper-IgM type 3
GWAS			Takayasu arteritis ( 25604533)
Interacting Genes		66 interacting genes: ABCF3 ADAP1 AICDA ATN1 ATP5F1B BBS2 CASP3 CASP6 CASP7 CDC25B CDC42 CEBPA CHEK2 COIL CREBBP DEPTOR DIP2A DMRT3 DTNBP1 DVL3 EAF1 EAF2 FAM90A1 FBXL12 FMR1 FOXD4L1 FXR1 FXR2 GPATCH2L HDAC5 HSPA5 IKZF3 INPP5J ITPKB KANSL1 KBTBD7 KLF2 LNX1 MDM2 MEOX2 NCOA3 NTAQ1 NUDT18 PFDN5 PICK1 PKD1L1 PRKAB2 PRR13 RDX RNF111 RPH3AL RPS27 SERF2 SIRT1 SMURF1 SPG7 TBXA2R THAP10 TNFAIP8L1 TP53 TXN2 UBE2H UBE2I WDR25 YWHAQ ZCCHC10	5 interacting genes: APP NEDD4L PSME3 RNF126 RPA1
Entrez ID		10197	57379
HPRD ID		05500	05585
Ensembl ID		ENSG00000131467	ENSG00000111732
Uniprot IDs		B3KQ25 P61289 V9HWJ8	Q546Y9 Q6QJ80 Q7Z599 Q9GZX7
PDB IDs		7YQC 7YQD	5JJ4 5W0R 5W0U 5W0Z 5W1C
Enriched GO Terms of Interacting Partners?		Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Cellular Response To Staurosporine Response To Nutrient Levels Protein Binding Protein Domain Specific Binding Nucleus Positive Regulation Of Long-term Neuronal Synaptic Plasticity Cellular Response To Nutrient Levels Macromolecule Catabolic Process Cytosol Positive Regulation Of Protein Metabolic Process Cellular Response To Alkaloid Post-translational Protein Modification Response To Xenobiotic Stimulus Neuron Projection Response To Alkaloid Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Leukocyte Apoptotic Process Response To UV Proteolysis Regulation Of Protein Metabolic Process Signal Transduction By P53 Class Mediator Mononuclear Cell Differentiation Protein-containing Complex Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Translation Regulator Activity Cellular Response To Glucose Starvation Cellular Response To Actinomycin D Positive Regulation Of Catabolic Process Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cytoplasm Developmental Process Modification-dependent Protein Catabolic Process PML Body Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of RNA Metabolic Process Protein Destabilization Response To Actinomycin D HLH Domain Binding Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Protein Stability Leukocyte Differentiation Protein Catabolic Process Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of MiRNA-mediated Gene Silencing Disordered Domain Specific Binding Glial Cell Apoptotic Process Positive Regulation Of Macromolecule Biosynthetic Process	Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Regulation Of Extrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Response To Calcium Ion Amylin Binding Endosome To Plasma Membrane Transport Vesicle Hemopoiesis Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Positive Regulation Of Endocytosis Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Regulation Of Protein Catabolic Process Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Recombinational Repair Double-strand Break Repair Via Homologous Recombination Proteasome Activator Complex Negative Regulation Of Sodium Ion Import Across Plasma Membrane Positive Regulation Of Caveolin-mediated Endocytosis Protein K48-linked Ubiquitination Protein Monoubiquitination Cytoplasm Protein Quality Control By The Ubiquitin-proteasome System Cytoplasm Protein Quality Control Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Protein Catabolic Process Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Single-stranded Telomeric DNA Binding Negative Regulation Of Protein Localization Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Double-strand Break Repair Negative Regulation Of Potassium Ion Export Across Plasma Membrane DNA Recombination
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