PKD1L1 and MGAT2

		PKD1L1	MGAT2
Description		polycystin 1 like 1, transient receptor potential channel interacting	alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cilium Membrane Calcium Channel Complex Cell Projection Ciliary Membrane Non-motile Cilium	Golgi Membrane Golgi Apparatus Golgi Stack Membrane
	Molecular Function	Calcium Channel Activity Protein Binding	Alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase Activity Transferase Activity Glycosyltransferase Activity Manganese Ion Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Detection Of Nodal Flow Monoatomic Ion Transport Calcium Ion Transport Monoatomic Ion Transmembrane Transport Detection Of Mechanical Stimulus Calcium Ion Transmembrane Transport Left/right Axis Specification Cell-cell Adhesion	Protein Glycosylation Protein N-linked Glycosylation Oligosaccharide Biosynthetic Process Protein N-linked Glycosylation Via Asparagine Viral Protein Processing
Pathways			Defective MGAT2 causes CDG-2a Maturation of spike protein Reactions specific to the complex N-glycan synthesis pathway
Drugs
Diseases			Congenital disorders of glycosylation (CDG) type II
GWAS		Anxiety disorder ( 25390645) Diastolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415) Gut microbiota alpha diversity (Shannon index) ( 33208821) Hepatitis C induced liver fibrosis ( 22841784) Obstructive sleep apnea during REM sleep (apnea hypopnea index) ( 29077507) Refractive error ( 32231278) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)	Blood protein levels ( 30072576)
Interacting Genes		11 interacting genes: ABCA13 ABCC3 ACAA2 C7orf57 CLK1 LINC02902 MGAT2 PKD1L1-AS1 PLCB2 PSME3 RPL6	4 interacting genes: GOLPH3 GOLPH3L PKD1L1 TIMM9
Entrez ID		168507	4247
HPRD ID		10154	04013
Ensembl ID		ENSG00000158683	ENSG00000168282
Uniprot IDs		Q8TDX9	Q10469
PDB IDs			5VCM 5VCR 5VCS
Enriched GO Terms of Interacting Partners?		Alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase Activity G-protein Beta/gamma-subunit Complex ATPase-coupled Transmembrane Transporter Activity Icosanoid Transmembrane Transporter Activity ABC-type Transporter Activity Glucuronoside Transmembrane Transporter Activity Glucuronoside Transport Ciliary Basal Body	Golgi Vesicle Budding Cargo Adaptor Activity Protein Targeting To Golgi Apparatus Golgi Cisterna Protein Targeting Establishment Of Protein Localization To Membrane Phosphatidylinositol-4-phosphate Binding Golgi To Plasma Membrane Protein Transport Vesicle Budding From Membrane Establishment Of Protein Localization To Organelle Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Establishment Of Protein Localization To Plasma Membrane Golgi To Plasma Membrane Transport Golgi Cisterna Membrane Localization Within Membrane Mitochondrial Intermembrane Space Membrane Organization Post-Golgi Vesicle-mediated Transport Golgi Organization Vesicle-mediated Transport To The Plasma Membrane Positive Regulation Of Protein Secretion Asymmetric Golgi Ribbon Formation Trans-Golgi Network Cell Adhesion Molecule Production Cellular Response To Rapamycin Detection Of Nodal Flow Protein Localization To Plasma Membrane Protein Transport Protein Retention In Golgi Apparatus Protein Localization To Cell Periphery Positive Regulation Of Protein Transport Mitochondrial Intermembrane Space Chaperone Complex Regulation Of Protein Secretion Response To Rapamycin Establishment Of Protein Localization Golgi Vesicle Transport TIM22 Mitochondrial Import Inner Membrane Insertion Complex Positive Regulation Of Secretion By Cell Vesicle Organization Positive Regulation Of Secretion Positive Regulation Of Establishment Of Protein Localization Protein Localization To Membrane Lipid Binding Golgi Ribbon Formation Cellular Localization Cellular Response To Ether Left/right Axis Specification Protein Transporter Activity Membrane Insertase Activity Regulation Of Protein Transport
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