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CDC34 and UBA1
Number of citations of the paper that reports this interaction (PubMedID
30097011
)
4
Data Source:
BioGRID
(enzymatic study)
CDC34
UBA1
Description
cell division cycle 34, ubiqiutin conjugating enzyme
ubiquitin like modifier activating enzyme 1
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytosol
Nuclear Speck
Heterochromatin
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Lysosomal Membrane
Cytosol
Endosome Membrane
Desmosome
Rough Endoplasmic Reticulum Membrane
Extracellular Exosome
Molecular Function
Ubiquitin-protein Transferase Activity
Protein Binding
ATP Binding
Ubiquitin Conjugating Enzyme Activity
RNA Binding
Ubiquitin Activating Enzyme Activity
Protein Binding
ATP Binding
Biological Process
G1/S Transition Of Mitotic Cell Cycle
Protein Polyubiquitination
DNA Replication Initiation
Cellular Protein Modification Process
Ubiquitin-dependent Protein Catabolic Process
Protein Ubiquitination
Cellular Response To Interferon-beta
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Neuron Apoptotic Process
Negative Regulation Of CAMP-mediated Signaling
Response To Growth Factor
Protein K48-linked Ubiquitination
Positive Regulation Of Inclusion Body Assembly
Ubiquitin-dependent Protein Catabolic Process
Cellular Response To DNA Damage Stimulus
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Pathways
Downstream TCR signaling
FCERI mediated NF-kB activation
CLEC7A (Dectin-1) signaling
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Antigen processing: Ubiquitination & Proteasome degradation
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Hexatantalum Dodecabromide
Quercetin
Diseases
GWAS
Interacting Genes
57 interacting genes:
ATF5
BTRC
CCNB1
CDK9
CDKN1B
CREM
CSNK2B
CUL1
CUL2
CUL3
EGFR
FBXL2
FBXL3
FBXO32
FBXO4
FBXO7
FBXW2
FBXW7
HIF1A
ING4
ITCH
MARCHF1
MARCHF2
MDM2
MEOX1
MEOX2
MUL1
MYBL2
MYOD1
NEDD4L
NEDD8
NFKBIA
PPARA
PPARG
PRKN
PTTG1
RBX1
RELA
RNF31
RNF7
ROCK1
SDCBP
SIAH1
SKP2
TBL1X
TRIM21
TRIM28
TRIM29
UBA1
UBB
UBE3B
USP2
USP21
VHL
WWP2
ZFAND6
ZNRF1
52 interacting genes:
ABCF1
BUB3
CDC34
CDK1
CHEK1
ECHS1
GAN
GRB2
HGS
HSPH1
LINC01554
MGMT
MTNR1A
OGT
PIAS3
SEMA3F
SMAD5
SUMO2
TAF9
TMCC2
TSSC4
TTC19
UBC
UBE2A
UBE2B
UBE2C
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E2
UBE2E3
UBE2G1
UBE2G2
UBE2H
UBE2J1
UBE2J2
UBE2K
UBE2L1
UBE2L3
UBE2L6
UBE2M
UBE2N
UBE2Q2
UBE2R2
UBE2S
UBE2T
UBE2U
UBE2W
UBE2Z
UBTD2
Entrez ID
997
7317
HPRD ID
00306
02440
Ensembl ID
ENSG00000099804
ENSG00000130985
Uniprot IDs
A0A024R1Z1
P49427
A0A024R1A3
P22314
PDB IDs
2OB4
3RZ3
4MDK
4P22
6DC6
Enriched GO Terms of Interacting Partners
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