UBA1 and UBE2L3

Number of citations of the paper that reports this interaction (PubMedID 29643511)
50

Data Source:
BioGRID (pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study)

		UBA1	UBE2L3
Description		ubiquitin like modifier activating enzyme 1	ubiquitin conjugating enzyme E2 L3
Image
GO Annotations	Cellular Component	Heterochromatin Nucleus Nucleoplasm Cytoplasm Mitochondrion Lysosomal Membrane Cytosol Endosome Membrane Desmosome Rough Endoplasmic Reticulum Membrane Extracellular Exosome	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	RNA Binding Ubiquitin Activating Enzyme Activity Protein Binding ATP Binding	Transcription Coactivator Activity RNA Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Enzyme Binding Ubiquitin Protein Ligase Binding Ubiquitin Conjugating Enzyme Activity Ubiquitin-protein Transferase Activator Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Cellular Response To DNA Damage Stimulus Protein Ubiquitination Protein Modification By Small Protein Conjugation	Protein Polyubiquitination Regulation Of Transcription, DNA-templated Cellular Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Cell Population Proliferation Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Cell Cycle Phase Transition Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Ubiquitin-protein Transferase Activity Protein K11-linked Ubiquitination Cellular Response To Steroid Hormone Stimulus Cellular Response To Glucocorticoid Stimulus Positive Regulation Of Protein Targeting To Mitochondrion
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation	Synthesis of active ubiquitin: roles of E1 and E2 enzymes E3 ubiquitin ligases ubiquitinate target proteins Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Hexatantalum Dodecabromide Quercetin
Diseases
GWAS			Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Ankylosing spondylitis ( 23749187) Apolipoprotein A1 levels ( 32203549) Celiac disease ( 22057235 20190752 30572963) Celiac disease and Rheumatoid arthritis ( 26546613) Celiac disease or Rheumatoid arthritis ( 21383967) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Eosinophil percentage of white cells ( 32888494) HDL cholesterol ( 24097068 25961943 20686565) HDL cholesterol levels ( 32203549 28334899 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Heel bone mineral density ( 30598549) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hepatitis B ( 24162738) High density lipoprotein cholesterol levels ( 29403010 33339817) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Inflammatory bowel disease ( 28067908 23128233) Intraocular pressure ( 29617998) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular hemoglobin concentration ( 32888494 27863252) Mean corpuscular volume ( 29403010 32888494 20139978 27863252 28017375) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Neutrophil percentage of white cells ( 32888494 27863252) Non-albumin protein levels ( 29403010) Optic disc size ( 31809533) Psoriasis ( 23143594) Red blood cell traits ( 23222517) Red cell distribution width ( 32888494 27863252 28957414) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Rheumatoid arthritis ( 30423114 24390342) Rheumatoid arthritis (ACPA-positive) ( 24532676) Systemic lupus erythematosus ( 27399966 23273568 26502338 21408207 28714469 19838193 19838195) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031) Total cholesterol levels ( 30275531) Ulcerative colitis ( 28067908)
Interacting Genes		52 interacting genes: ABCF1 BUB3 CDC34 CDK1 CHEK1 ECHS1 GAN GRB2 HGS HSPH1 LINC01554 MGMT MTNR1A OGT PIAS3 SEMA3F SMAD5 SUMO2 TAF9 TMCC2 TSSC4 TTC19 UBC UBE2A UBE2B UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2G1 UBE2G2 UBE2H UBE2J1 UBE2J2 UBE2K UBE2L1 UBE2L3 UBE2L6 UBE2M UBE2N UBE2Q2 UBE2R2 UBE2S UBE2T UBE2U UBE2W UBE2Z UBTD2	109 interacting genes: ANKIB1 AREL1 ARIH1 ARIH2 ATXN3 BRAP BRCA1 CBL CBLB CBLC CCNB1IP1 CDC42 CDKN1B CUL9 DTX3 FBXO2 FOS HACE1 HECTD1 HECTD2 HECTD4 HECW1 HECW2 HERC1 HERC2 HERC3 HERC4 HERC6 HSPA4 HUWE1 IRF2BP1 ITCH LIG4 LTN1 MAPK6 MDM2 MEX3A MEX3C MID1 MKRN2 MKRN3 MUL1 MYCBP2 NEDD4 NEDD4L NFKBIA NR3C1 OTUB1 OTUD3 PIAS1 PIAS2 PJA1 POLR2A PRKN PTEN RBCK1 RBX1 RC3H1 RELA RNF103 RNF113B RNF114 RNF125 RNF14 RNF144A RNF144B RNF150 RNF168 RNF170 RNF182 RNF19A RNF19B RNF2 RNF20 RNF213 RNF216 RNF220 RNF31 RNF7 RTF2 SMAD4 SMAD7 SMURF1 SMURF2 STUB1 TP53 TRAF6 TRAF7 TRIM21 TRIM23 TRIM25 TRIM28 TRIM31 TRIM39 TRIM55 TRIP12 UBA1 UBA5 UBA6 UBA7 UBASH3A UBE3A UBE3C UBOX5 UBR4 UBR5 VPS11 WWP1 WWP2
Entrez ID		7317	7332
HPRD ID		02440	04762
Ensembl ID		ENSG00000130985	ENSG00000185651
Uniprot IDs		A0A024R1A3 P22314	A0A024R1A4 P68036
PDB IDs		4P22 6DC6	1C4Z 1FBV 3SQV 3SY2 4Q5E 4Q5H 5HPT 5TTE 5UDH 6CP2 6DJW 6DJX 6N13 6XXU 7B5L 7B5N
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?