CDC34 and PPARA

Number of citations of the paper that reports this interaction (PubMedID 26556865)
9

Data Source:
BioGRID (pull down)

		CDC34	PPARA
Description		cell division cycle 34, ubiqiutin conjugating enzyme	peroxisome proliferator activated receptor alpha
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Nuclear Speck	Chromatin Nucleus Nucleoplasm
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin Conjugating Enzyme Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coactivator Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Steroid Hormone Receptor Activity Nuclear Receptor Activity Protein Binding Transcription Factor Binding Zinc Ion Binding Lipid Binding Phosphatase Binding Protein Domain Specific Binding Ubiquitin Conjugating Enzyme Binding Sequence-specific DNA Binding Protein-containing Complex Binding NFAT Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding MDM2/MDM4 Family Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Protein Polyubiquitination DNA Replication Initiation Cellular Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Cellular Response To Interferon-beta Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of CAMP-mediated Signaling Response To Growth Factor Protein K48-linked Ubiquitination Positive Regulation Of Inclusion Body Assembly	Negative Regulation Of Transcription By RNA Polymerase II Response To Hypoxia Fatty Acid Metabolic Process Heart Development Epidermis Development Cellular Response To Starvation Hormone-mediated Signaling Pathway Regulation Of Cellular Ketone Metabolic Process Negative Regulation Of Macrophage Derived Foam Cell Differentiation Lipid Localization Negative Regulation Of Cholesterol Storage Negative Regulation Of Sequestering Of Triglyceride Regulation Of Lipid Metabolic Process Regulation Of Fatty Acid Metabolic Process Cell Differentiation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Intracellular Receptor Signaling Pathway Positive Regulation Of Fatty Acid Beta-oxidation Negative Regulation Of Protein Binding Negative Regulation Of Appetite Response To Insulin Circadian Regulation Of Gene Expression Response To Lipid Behavioral Response To Nicotine Wound Healing Lipoprotein Metabolic Process Regulation Of Circadian Rhythm Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Viral Genome Replication Response To Ethanol Positive Regulation Of Gluconeogenesis Negative Regulation Of Blood Pressure Negative Regulation Of Glycolytic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Fatty Acid Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Fatty Acid Oxidation Positive Regulation Of Lipid Biosynthetic Process Negative Regulation Of Inflammatory Response Negative Regulation Of Protein Kinase B Signaling Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Enamel Mineralization Negative Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Neuron Death Negative Regulation Of Pri-miRNA Transcription By RNA Polymerase II Negative Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Negative Regulation Of Hepatocyte Apoptotic Process Regulation Of Fatty Acid Transport Negative Regulation Of Signaling Receptor Activity Positive Regulation Of ATP Biosynthetic Process
Pathways		Downstream TCR signaling FCERI mediated NF-kB activation CLEC7A (Dectin-1) signaling Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation	RORA activates gene expression BMAL1:CLOCK,NPAS2 activates circadian gene expression PPARA activates gene expression PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) Transcriptional regulation of white adipocyte differentiation Nuclear Receptor transcription pathway Regulation of lipid metabolism by PPARalpha Circadian Clock SUMOylation of intracellular receptors Cytoprotection by HMOX1 Heme signaling
Drugs			alpha-Linolenic acid Icosapent Troglitazone Valproic acid Indomethacin Rosiglitazone Fenoprofen Clofibrate Fenofibrate Ibuprofen Amiodarone Gemfibrozil Bezafibrate Prasterone N,N-Bis(3-(D-gluconamido)propyl)deoxycholamide Flufenamic acid Resveratrol Phthalic Acid Lauric acid Stearic acid Doconexent Palmitic Acid Oleic Acid Caprylic acid Arachidonic Acid Reglitazar Elafibranor Cardarine Muraglitazar Ertiprotafib Ragaglitazar Tesaglitazar GW-590735 Indeglitazar Myristic acid Aleglitazar Clinofibrate Ciprofibrate Dexibuprofen Soybean oil Omega-3 fatty acids Myrrh Isoflavone Leukotriene B4 Fenofibric acid Fish oil
Diseases
GWAS			Cholesterol, total ( 24097068) CTACK levels ( 27989323) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Hip circumference adjusted for BMI ( 34021172) Impulsivity (motor) ( 30718321) LDL cholesterol ( 24097068) Liver enzyme levels (alkaline phosphatase) ( 33972514) Refractive error ( 32231278) Resting-state electroencephalogram vigilance ( 29703947) Triglyceride levels ( 32203549) Type 2 diabetes ( 31049640) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)
Interacting Genes		57 interacting genes: ATF5 BTRC CCNB1 CDK9 CDKN1B CREM CSNK2B CUL1 CUL2 CUL3 EGFR FBXL2 FBXL3 FBXO32 FBXO4 FBXO7 FBXW2 FBXW7 HIF1A ING4 ITCH MARCHF1 MARCHF2 MDM2 MEOX1 MEOX2 MUL1 MYBL2 MYOD1 NEDD4L NEDD8 NFKBIA PPARA PPARG PRKN PTTG1 RBX1 RELA RNF31 RNF7 ROCK1 SDCBP SIAH1 SKP2 TBL1X TRIM21 TRIM28 TRIM29 UBA1 UBB UBE3B USP2 USP21 VHL WWP2 ZFAND6 ZNRF1	70 interacting genes: AIP AKAP13 ANKRD11 AQP1 BCL2 CCDC179 CDC34 CDK3 CEP350 CHD9 CHIC2 COL8A1 CTNNA3 DAP3 DUT EP300 EXOSC4 FABP1 FAM90A1 FAM9B FBLN1 FOXA3 GADD45A GADD45B GADD45G GPANK1 HELZ2 HOXC8 HSP90AA1 KCTD7 KRTAP10-1 LAMTOR5 MAPK1 MAPK3 MECR MED1 MED24 NCOA1 NCOA2 NCOA3 NCOR1 NCOR2 NR1H2 NR1H3 NRBF2 NRIP1 PAQR3 PICK1 PIK3R3 POU1F1 PPARGC1A PPARGC1B PRKCA PRKCD PRMT1 PRMT8 RELA RXRA RXRG SDCBP SIRT1 STAC3 TNP1 TRIM55 TRIM63 UBE2I VWA5A VWC2L ZNF587 ZSCAN23
Entrez ID		997	5465
HPRD ID		00306	01369
Ensembl ID		ENSG00000099804	ENSG00000186951
Uniprot IDs		A0A024R1Z1 P49427	F1D8S4 Q07869
PDB IDs		2OB4 3RZ3 4MDK	1I7G 1K7L 1KKQ 2NPA 2P54 2REW 2ZNN 3ET1 3FEI 3G8I 3KDT 3KDU 3SP6 3VI8 4BCR 4CI4 5AZT 5HYK 6KAX 6KAY 6KAZ 6KB0 6KB1 6KB2 6KB3 6KB4 6KB5 6KB6 6KB7 6KB8 6KB9 6KBA 6KXX 6KXY 6KYP 6L36 6L37 6L38 6L96 6LX4 6LX5 6LX6 6LX7 6LX8 6LX9 6LXA 6LXB 6LXC 7BPY 7BPZ 7BQ0 7BQ1 7BQ2 7BQ3 7BQ4
Enriched GO Terms of Interacting Partners?
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