CDC34 and FBXW2

Number of citations of the paper that reports this interaction (PubMedID 10531035)
133

Data Source:
BioGRID (enzymatic study)

		CDC34	FBXW2
Description		cell division cycle 34, ubiqiutin conjugating enzyme	F-box and WD repeat domain containing 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Nuclear Speck	Cytosol
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin Conjugating Enzyme Activity	Ubiquitin-protein Transferase Activity Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Protein Polyubiquitination DNA Replication Initiation Cellular Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Cellular Response To Interferon-beta Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of CAMP-mediated Signaling Response To Growth Factor Protein K48-linked Ubiquitination Positive Regulation Of Inclusion Body Assembly	Cellular Protein Modification Process Proteolysis Protein Ubiquitination
Pathways		Downstream TCR signaling FCERI mediated NF-kB activation CLEC7A (Dectin-1) signaling Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation	Association of TriC/CCT with target proteins during biosynthesis Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Hip circumference adjusted for BMI ( 25673412)
Interacting Genes		57 interacting genes: ATF5 BTRC CCNB1 CDK9 CDKN1B CREM CSNK2B CUL1 CUL2 CUL3 EGFR FBXL2 FBXL3 FBXO32 FBXO4 FBXO7 FBXW2 FBXW7 HIF1A ING4 ITCH MARCHF1 MARCHF2 MDM2 MEOX1 MEOX2 MUL1 MYBL2 MYOD1 NEDD4L NEDD8 NFKBIA PPARA PPARG PRKN PTTG1 RBX1 RELA RNF31 RNF7 ROCK1 SDCBP SIAH1 SKP2 TBL1X TRIM21 TRIM28 TRIM29 UBA1 UBB UBE3B USP2 USP21 VHL WWP2 ZFAND6 ZNRF1	11 interacting genes: BTRC CDC34 CLVS2 CTNNB1 CUL1 EXOSC2 MSX2 MYB SKP1 TRIM54 UBE2D2
Entrez ID		997	26190
HPRD ID		00306	09950
Ensembl ID		ENSG00000099804	ENSG00000119402
Uniprot IDs		A0A024R1Z1 P49427	B4DT60 Q9UKT8
PDB IDs		2OB4 3RZ3 4MDK
Enriched GO Terms of Interacting Partners?
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