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PPARA and SIRT1
Number of citations of the paper that reports this interaction (PubMedID
19356714
)
436
Data Source:
BioGRID
(pull down, pull down)
PPARA
SIRT1
Description
peroxisome proliferator activated receptor alpha
sirtuin 1
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Chromatin
Euchromatin
Heterochromatin
Fibrillar Center
Nucleus
Nuclear Envelope
Nuclear Inner Membrane
Nucleoplasm
Chromatin Silencing Complex
Nucleolus
Cytoplasm
Mitochondrion
Cytosol
PML Body
RDNA Heterochromatin
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Transcription Coactivator Binding
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Steroid Hormone Receptor Activity
Nuclear Receptor Activity
Protein Binding
Transcription Factor Binding
Zinc Ion Binding
Lipid Binding
Phosphatase Binding
Protein Domain Specific Binding
Ubiquitin Conjugating Enzyme Binding
Sequence-specific DNA Binding
Protein-containing Complex Binding
NFAT Protein Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
MDM2/MDM4 Family Protein Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
P53 Binding
Transcription Coactivator Activity
Transcription Corepressor Activity
NAD+ ADP-ribosyltransferase Activity
Histone Deacetylase Activity
Protein Binding
Protein C-terminus Binding
Transcription Factor Binding
Nuclear Receptor Binding
NAD-dependent Histone Deacetylase Activity
Deacetylase Activity
Enzyme Binding
Protein Deacetylase Activity
NAD-dependent Protein Deacetylase Activity
Histone Binding
Identical Protein Binding
HLH Domain Binding
BHLH Transcription Factor Binding
Metal Ion Binding
NAD-dependent Histone Deacetylase Activity (H3-K9 Specific)
Mitogen-activated Protein Kinase Binding
NAD+ Binding
Protein-propionyllysine Depropionylase Activity
Keratin Filament Binding
Promoter-specific Chromatin Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Response To Hypoxia
Fatty Acid Metabolic Process
Heart Development
Epidermis Development
Cellular Response To Starvation
Hormone-mediated Signaling Pathway
Regulation Of Cellular Ketone Metabolic Process
Negative Regulation Of Macrophage Derived Foam Cell Differentiation
Lipid Localization
Negative Regulation Of Cholesterol Storage
Negative Regulation Of Sequestering Of Triglyceride
Regulation Of Lipid Metabolic Process
Regulation Of Fatty Acid Metabolic Process
Cell Differentiation
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Intracellular Receptor Signaling Pathway
Positive Regulation Of Fatty Acid Beta-oxidation
Negative Regulation Of Protein Binding
Negative Regulation Of Appetite
Response To Insulin
Circadian Regulation Of Gene Expression
Response To Lipid
Behavioral Response To Nicotine
Wound Healing
Lipoprotein Metabolic Process
Regulation Of Circadian Rhythm
Steroid Hormone Mediated Signaling Pathway
Positive Regulation Of Viral Genome Replication
Response To Ethanol
Positive Regulation Of Gluconeogenesis
Negative Regulation Of Blood Pressure
Negative Regulation Of Glycolytic Process
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Fatty Acid Metabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Fatty Acid Oxidation
Positive Regulation Of Lipid Biosynthetic Process
Negative Regulation Of Inflammatory Response
Negative Regulation Of Protein Kinase B Signaling
Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development
Enamel Mineralization
Negative Regulation Of Cytokine Production Involved In Inflammatory Response
Negative Regulation Of Neuron Death
Negative Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Negative Regulation Of Leukocyte Cell-cell Adhesion
Negative Regulation Of Reactive Oxygen Species Biosynthetic Process
Negative Regulation Of Hepatocyte Apoptotic Process
Regulation Of Fatty Acid Transport
Negative Regulation Of Signaling Receptor Activity
Positive Regulation Of ATP Biosynthetic Process
Single Strand Break Repair
Negative Regulation Of Transcription By RNA Polymerase II
RDNA Heterochromatin Assembly
Pyrimidine Dimer Repair By Nucleotide-excision Repair
DNA Synthesis Involved In DNA Repair
Angiogenesis
Ovulation From Ovarian Follicle
Cellular Glucose Homeostasis
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Endothelial Cell Proliferation
Positive Regulation Of Adaptive Immune Response
Chromatin Organization
DNA Methylation-dependent Heterochromatin Assembly
Protein ADP-ribosylation
Protein Deacetylation
Triglyceride Mobilization
Cellular Response To DNA Damage Stimulus
Response To Oxidative Stress
Transforming Growth Factor Beta Receptor Signaling Pathway
Spermatogenesis
Regulation Of Mitotic Cell Cycle
Muscle Organ Development
Cell Aging
Positive Regulation Of Cell Population Proliferation
Cellular Response To Starvation
Negative Regulation Of Gene Expression
Regulation Of Centrosome Duplication
Positive Regulation Of Cholesterol Efflux
Regulation Of Lipid Storage
Regulation Of Glucose Metabolic Process
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Positive Regulation Of Macroautophagy
Protein Ubiquitination
Histone Deacetylation
Peptidyl-lysine Acetylation
Macrophage Differentiation
Negative Regulation Of Cell Growth
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of Prostaglandin Biosynthetic Process
Heterochromatin Assembly
Protein Destabilization
Negative Regulation Of TOR Signaling
Regulation Of Endodeoxyribonuclease Activity
Negative Regulation Of NF-kappaB Transcription Factor Activity
Response To Insulin
Circadian Regulation Of Gene Expression
Leptin-mediated Signaling Pathway
Regulation Of Smooth Muscle Cell Apoptotic Process
Peptidyl-lysine Deacetylation
Cellular Triglyceride Homeostasis
Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway
Regulation Of Cell Population Proliferation
Negative Regulation Of Phosphorylation
Response To Hydrogen Peroxide
Behavioral Response To Starvation
Cholesterol Homeostasis
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Regulation Of Apoptotic Process
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Negative Regulation Of DNA-binding Transcription Factor Activity
Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Response To Leptin
Positive Regulation Of MHC Class II Biosynthetic Process
Negative Regulation Of Fat Cell Differentiation
Positive Regulation Of Gluconeogenesis
Positive Regulation Of DNA Repair
Positive Regulation Of Angiogenesis
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Insulin Receptor Signaling Pathway
White Fat Cell Differentiation
Negative Regulation Of Helicase Activity
Positive Regulation Of Smooth Muscle Cell Differentiation
Positive Regulation Of Histone H3-K9 Methylation
Negative Regulation Of Protein Kinase B Signaling
Fatty Acid Homeostasis
Negative Regulation Of Androgen Receptor Signaling Pathway
Positive Regulation Of Macrophage Cytokine Production
Histone H3-K9 Modification
Cellular Response To Hydrogen Peroxide
Regulation Of Bile Acid Biosynthetic Process
UV-damage Excision Repair
Histone H3 Deacetylation
Cellular Response To Tumor Necrosis Factor
Negative Regulation Of Histone H3-K14 Acetylation
Cellular Response To Hypoxia
Cellular Response To Ionizing Radiation
Regulation Of Protein Serine/threonine Kinase Activity
Regulation Of Brown Fat Cell Differentiation
Stress-induced Premature Senescence
Protein Depropionylation
Regulation Of Cellular Response To Heat
Negative Regulation Of Histone H3-K9 Trimethylation
Negative Regulation Of Neuron Death
Negative Regulation Of Protein Acetylation
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Adipose Tissue Development
Histone H3-K9 Deacetylation
Cellular Response To Leukemia Inhibitory Factor
Positive Regulation Of Macrophage Apoptotic Process
Negative Regulation Of CAMP-dependent Protein Kinase Activity
Positive Regulation Of CAMP-dependent Protein Kinase Activity
Negative Regulation Of Histone H4-K16 Acetylation
Negative Regulation Of Cellular Response To Testosterone Stimulus
Negative Regulation Of Peptidyl-lysine Acetylation
Negative Regulation Of Cellular Senescence
Positive Regulation Of Cellular Senescence
Pathways
RORA activates gene expression
BMAL1:CLOCK,NPAS2 activates circadian gene expression
PPARA activates gene expression
PPARA activates gene expression
Transcriptional activation of mitochondrial biogenesis
Activation of gene expression by SREBF (SREBP)
Transcriptional regulation of white adipocyte differentiation
Nuclear Receptor transcription pathway
Regulation of lipid metabolism by PPARalpha
Circadian Clock
SUMOylation of intracellular receptors
Cytoprotection by HMOX1
Heme signaling
Regulation of HSF1-mediated heat shock response
Circadian Clock
SIRT1 negatively regulates rRNA expression
SIRT1 negatively regulates rRNA expression
Regulation of FOXO transcriptional activity by acetylation
Regulation of FOXO transcriptional activity by acetylation
Heme signaling
Drugs
alpha-Linolenic acid
Icosapent
Troglitazone
Valproic acid
Indomethacin
Rosiglitazone
Fenoprofen
Clofibrate
Fenofibrate
Ibuprofen
Amiodarone
Gemfibrozil
Bezafibrate
Prasterone
N,N-Bis(3-(D-gluconamido)propyl)deoxycholamide
Flufenamic acid
Resveratrol
Phthalic Acid
Lauric acid
Stearic acid
Doconexent
Palmitic Acid
Oleic Acid
Caprylic acid
Arachidonic Acid
Reglitazar
Elafibranor
Cardarine
Muraglitazar
Ertiprotafib
Ragaglitazar
Tesaglitazar
GW-590735
Indeglitazar
Myristic acid
Aleglitazar
Clinofibrate
Ciprofibrate
Dexibuprofen
Soybean oil
Omega-3 fatty acids
Myrrh
Isoflavone
Leukotriene B4
Fenofibric acid
Fish oil
Resveratrol
Selisistat
Cambinol
Diseases
GWAS
Cholesterol, total (
24097068
)
CTACK levels (
27989323
)
Eosinophil counts (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Hip circumference adjusted for BMI (
34021172
)
Impulsivity (motor) (
30718321
)
LDL cholesterol (
24097068
)
Liver enzyme levels (alkaline phosphatase) (
33972514
)
Refractive error (
32231278
)
Resting-state electroencephalogram vigilance (
29703947
)
Triglyceride levels (
32203549
)
Type 2 diabetes (
31049640
)
Very long-chain saturated fatty acid levels (fatty acid 20:0) (
25378659
)
Atrial fibrillation (
30061737
)
Chronotype (
30696823
)
Diverticular disease (
30177863
)
Molybdenum levels (
26025379
)
Pulse pressure (
30224653
)
Interacting Genes
70 interacting genes:
AIP
AKAP13
ANKRD11
AQP1
BCL2
CCDC179
CDC34
CDK3
CEP350
CHD9
CHIC2
COL8A1
CTNNA3
DAP3
DUT
EP300
EXOSC4
FABP1
FAM90A1
FAM9B
FBLN1
FOXA3
GADD45A
GADD45B
GADD45G
GPANK1
HELZ2
HOXC8
HSP90AA1
KCTD7
KRTAP10-1
LAMTOR5
MAPK1
MAPK3
MECR
MED1
MED24
NCOA1
NCOA2
NCOA3
NCOR1
NCOR2
NR1H2
NR1H3
NRBF2
NRIP1
PAQR3
PICK1
PIK3R3
POU1F1
PPARGC1A
PPARGC1B
PRKCA
PRKCD
PRMT1
PRMT8
RELA
RXRA
RXRG
SDCBP
SIRT1
STAC3
TNP1
TRIM55
TRIM63
UBE2I
VWA5A
VWC2L
ZNF587
ZSCAN23
65 interacting genes:
AFP
AKT1
AR
ARNTL
BAZ1B
BCL11A
BHLHE41
BRIP1
CDK6
CENATAC
CHFR
CLOCK
CSNK2B
CTTN
E2F1
EP300
ESRRA
EZH2
FOS
FOXM1
FOXO1
FOXO3
GAPDH
H1-5
H3C1
HES1
HEY2
HIC1
HIPK2
HNF4A
HOXB9
MAPK8
MPHOSPH8
MYCN
NBN
NDN
NMNAT1
NR1H2
NR1H3
NR1H4
PARP1
PML
PPARA
PPARG
PPARGC1A
PRMT1
PSME3
RARA
RELA
RICTOR
RRP8
SATB1
SETD7
SMAD7
SMURF2
SNW1
STK11
STK4
SUMO2
TP53
TP73
TRIM28
UBE2I
USP22
VDR
Entrez ID
5465
23411
HPRD ID
01369
08381
Ensembl ID
ENSG00000186951
ENSG00000096717
Uniprot IDs
F1D8S4
Q07869
A0A024QZQ1
A8K128
B0QZ35
E9PC49
Q96EB6
PDB IDs
1I7G
1K7L
1KKQ
2NPA
2P54
2REW
2ZNN
3ET1
3FEI
3G8I
3KDT
3KDU
3SP6
3VI8
4BCR
4CI4
5AZT
5HYK
6KAX
6KAY
6KAZ
6KB0
6KB1
6KB2
6KB3
6KB4
6KB5
6KB6
6KB7
6KB8
6KB9
6KBA
6KXX
6KXY
6KYP
6L36
6L37
6L38
6L96
6LX4
6LX5
6LX6
6LX7
6LX8
6LX9
6LXA
6LXB
6LXC
7BPY
7BPZ
7BQ0
7BQ1
7BQ2
7BQ3
7BQ4
4I5I
4IF6
4IG9
4KXQ
4ZZH
4ZZI
4ZZJ
5BTR
Enriched GO Terms of Interacting Partners
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