TRIM14 and DHX58

Number of citations of the paper that reports this interaction (PubMedID 33373584)
7

Data Source:
BioGRID (pull down)

		TRIM14	DHX58
Description		tripartite motif containing 14	DExH-box helicase 58
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrial Outer Membrane Cytosol Phagocytic Vesicle	Cytoplasm
	Molecular Function	Transcription Coactivator Activity Protein Binding Zinc Ion Binding Protein Kinase Binding Protein Homodimerization Activity Ubiquitin Protein Ligase Activity	DNA Binding RNA Helicase Activity Double-stranded RNA Binding Single-stranded RNA Binding Protein Binding ATP Binding Zinc Ion Binding ATP Hydrolysis Activity
	Biological Process	Protein Polyubiquitination Regulation Of Gene Expression Positive Regulation Of Autophagy Protein Ubiquitination Regulation Of Protein Localization Negative Regulation Of Viral Transcription Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Positive Regulation Of Transcription, DNA-templated Regulation Of Viral Entry Into Host Cell Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity	Response To Virus Response To Bacterium Negative Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Positive Regulation Of Interferon-beta Production Negative Regulation Of MDA-5 Signaling Pathway Negative Regulation Of RIG-I Signaling Pathway Innate Immune Response Regulation Of Innate Immune Response Negative Regulation Of Innate Immune Response Defense Response To Virus Positive Regulation Of MDA-5 Signaling Pathway Positive Regulation Of RIG-I Signaling Pathway
Pathways		Interferon gamma signaling	DDX58/IFIH1-mediated induction of interferon-alpha/beta
Drugs
Diseases
GWAS		Multiple sclerosis ( 31604244)	Coronary artery disease ( 29212778) Fasting plasma glucose ( 31932636) Mean spheric corpuscular volume ( 32888494)
Interacting Genes		85 interacting genes: ABCF3 ADAMTS12 ALG13 AP3M1 ATP1B1 ATP1B3 ATP2A2 ATP5PB ATP6V1H BYSL CARD9 CCDC125 CCDC57 CCDC6 CENPC CIB3 CKS1B CSPP1 DHX58 EIF3G ERCC3 ETFBKMT EXOC8 FAM50B FAT1 GOLGA2 GOLGA6L9 HERC3 HEXIM2 HNRNPF IHO1 ITM2A IVNS1ABP KAT2B KIF3A KIFC3 LAMTOR1 LNX1 MAPRE3 MITD1 MNAT1 MRPL24 MYO15B NCOR1 NDUFA9 NFAT5 NPC2 PCGF6 PDIA6 PHF11 PIM2 PLCG1 POLR1C POLR2G PPP2R3C PRDM6 PRKAB2 PRPF31 PTPN21 RAB5A RAB9A RAD51D RBM33 RLF RNF125 RNF20 SLF2 SMARCB1 SMIM3 SPG21 STK38 TAX1BP1 TMEM167A TRAF2 TSGA10 UBE2B UBE2N UNK VIM WDR35 WRNIP1 ZC4H2 ZFP36L2 ZGPAT ZNF652	10 interacting genes: AGO2 AP2B1 APP DHX30 DICER1 EIF2AK2 EIF6 NKRF STAU2 TRIM14
Entrez ID		9830	79132
HPRD ID		05948	13115
Ensembl ID		ENSG00000106785	ENSG00000108771
Uniprot IDs		A0A024R165 Q14142	A0A024R1Y5 Q96C10
PDB IDs		6JBM	2RQA 2W4R 3EQT
Enriched GO Terms of Interacting Partners?
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