CDK1 and RPA2

Number of citations of the paper that reports this interaction (PubMedID 1318195)
85

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)
HPRD (in vitro, in vivo)

		CDK1	RPA2
Description		cyclin dependent kinase 1	replication protein A2
Image
GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Matrix Endoplasmic Reticulum Membrane Centrosome Cytosol Spindle Microtubule Membrane Midbody Extracellular Exosome Mitotic Spindle Cyclin B1-CDK1 Complex	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm DNA Replication Factor A Complex Nuclear Body PML Body Site Of Double-strand Break
	Molecular Function	Virus Receptor Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Cyclin Binding Histone Kinase Activity Cyclin-dependent Protein Kinase Activity Protein Serine Kinase Activity	Damaged DNA Binding Single-stranded DNA Binding Protein Binding Enzyme Binding Protein Phosphatase Binding Ubiquitin Protein Ligase Binding Protein N-terminus Binding G-rich Strand Telomeric DNA Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Microtubule Cytoskeleton Organization DNA Replication DNA Repair Protein Phosphorylation Apoptotic Process Mitotic G2 DNA Damage Checkpoint Signaling Centrosome Cycle Pronuclear Fusion Cell Aging Response To Xenobiotic Stimulus Response To Toxic Substance Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Schwann Cell Differentiation Response To Organic Cyclic Compound Response To Amine Response To Activity Cell Migration Histone Phosphorylation Protein Deubiquitination Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Chromosome Condensation Epithelial Cell Differentiation Animal Organ Regeneration Protein Localization To Kinetochore Positive Regulation Of Protein Import Into Nucleus Regulation Of Circadian Rhythm Negative Regulation Of Apoptotic Process Response To Ethanol Positive Regulation Of DNA Replication Regulation Of Embryonic Development Response To Cadmium Ion Response To Copper Ion Viral Entry Into Host Cell Rhythmic Process Response To Axon Injury Cell Division Ventricular Cardiac Muscle Cell Development Positive Regulation Of Cardiac Muscle Cell Proliferation Protein-containing Complex Assembly Cellular Response To Hydrogen Peroxide ERK1 And ERK2 Cascade Golgi Disassembly Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport	Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Replication Base-excision Repair Nucleotide-excision Repair Mismatch Repair Regulation Of Double-strand Break Repair Via Homologous Recombination Mitotic G1 DNA Damage Checkpoint Signaling Protein Localization To Chromosome Regulation Of DNA Damage Checkpoint
Pathways		MAPK3 (ERK1) activation E2F-enabled inhibition of pre-replication complex formation Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 Golgi Cisternae Pericentriolar Stack Reorganization Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes APC/C:Cdc20 mediated degradation of Cyclin B Cdc20:Phospho-APC/C mediated degradation of Cyclin A Regulation of APC/C activators between G1/S and early anaphase Phosphorylation of the APC/C Phosphorylation of Emi1 Condensation of Prophase Chromosomes MASTL Facilitates Mitotic Progression Resolution of Sister Chromatid Cohesion Condensation of Prometaphase Chromosomes Regulation of PLK1 Activity at G2/M Transition Activation of NIMA Kinases NEK9, NEK6, NEK7 Initiation of Nuclear Envelope (NE) Reformation Nuclear Pore Complex (NPC) Disassembly Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Depolymerisation of the Nuclear Lamina Anchoring of the basal body to the plasma membrane MAPK6/MAPK4 signaling Ovarian tumor domain proteases TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Regulation of TP53 Degradation Mitotic Prophase G1/S-Specific Transcription Cyclin A/B1/B2 associated events during G2/M transition Cyclin A/B1/B2 associated events during G2/M transition G2/M DNA replication checkpoint Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex The role of GTSE1 in G2/M progression after G2 checkpoint AURKA Activation by TPX2 Transcriptional regulation by RUNX2	Translesion synthesis by REV1 Recognition of DNA damage by PCNA-containing replication complex Translesion Synthesis by POLH Removal of the Flap Intermediate from the C-strand Activation of ATR in response to replication stress Regulation of HSF1-mediated heat shock response HSF1 activation Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) PCNA-Dependent Long Patch Base Excision Repair Translesion synthesis by POLK Translesion synthesis by POLI Termination of translesion DNA synthesis HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Formation of Incision Complex in GG-NER Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Fanconi Anemia Pathway Regulation of TP53 Activity through Phosphorylation Activation of the pre-replicative complex Removal of the Flap Intermediate G2/M DNA damage checkpoint Meiotic recombination
Drugs		Indirubin-3'-monoxime Olomoucine Hymenialdisine SU9516 Alvocidib Alsterpaullone Seliciclib AT-7519 Fostamatinib
Diseases
GWAS		Cocaine dependence ( 23958962) Voxel-wise structural brain imaging measurements in Alzheimerâ€™s disease ( 31095298)	HDL cholesterol levels ( 32203549) Platelet count ( 32888494) Plateletcrit ( 32888494) White blood cell count ( 32888494)
Interacting Genes		188 interacting genes: ABL1 AMPH APLP2 AR ARID4A BARD1 BCL2 BIRC5 BIRC6 BRCA1 BRCA2 BTRC BUB1 CALD1 CCNA1 CCNA2 CCNB1 CCNB1IP1 CCNB2 CCNE1 CCP110 CD8A CDC20 CDC25A CDC25B CDC25C CDC6 CDCA2 CDCA5 CDK7 CDKN1A CDKN1B CDKN3 CDT1 CEP55 CEP63 CHAF1B CIITA CKS2 CNOT7 CREM CSN2 CSNK2A1 CSNK2B CTNNB1 CUX1 CXCR1 DAB2 DCTN6 DNM2 DTL DUT E2F1 ECT2 EEF1D EEF2K EGFR EP300 EPN1 ERCC2 FANCA FANCC FANCG FBXO5 FEN1 FOXM1 FYN GADD45A GADD45B GADD45G GATA2 GBF1 GFAP GOLGA2 GORASP1 H1-0 H1-1 H1-3 H1-5 H2AC4 H2BC3 H4C1 HMGA1 HMGA2 HMGB1 HSPA2 HTRA2 IL16 IL3RA IPO13 ITGB3 ITPR1 JAK3 KAT5 KHDRBS1 KIF11 KIF20B KIF26B KMT2E KRT18 LATS1 LMNA LMNB1 LYN LZTS1 MAP4 MAPT MBP MCM4 MDM4 MEF2C MKI67 MLKL MNDA MYC MYT1 NCAPD2 NCAPG NCAPH NCL NDE1 NES NPM1 NSFL1C NUP210 PAK6 PBK PCNA PIN1 PITPNM1 PKMYT1 PLEC PML POLA1 PPP2R1A PPP2R1B PPP2R2B PRC1 PTCH1 PTMA PTPN1 PTPN2 PTPN6 PTTG1 RAB4A RAB5B RACGAP1 RAP1GAP RB1 RCC1 RELB REPS2 RFX3 RGCC RPA2 RPS6KB1 RRM2 RUNX1 RUNX2 SFN SP1 SPAG5 SQSTM1 SRC SSBP1 STK3 STMN1 STMN2 TFDP1 TGFBR2 TK1 TLE1 TNNC1 TOP2A TP53 TP53BP1 TP73 TSC1 TSPYL2 UBA1 UBE2A UBE3A UHRF2 USP16 VIM WEE1 XIAP ZBTB16	65 interacting genes: ACP5 AKAP9 APP ATM CALCOCO2 CASK CCNC CCNO CDC5L CDK1 CEP126 CFB COPS6 CRMP1 DMRTB1 EEF1A1 EIF4G2 ERCC1 ERCC4 GAPDH GOLM1 HERPUD1 HNRNPUL1 HUS1 LNX2 LRIF1 MARK2 MCM2 MCM5 MED1 MED31 MEN1 NDEL1 ORC1 ORC2 ORC4 ORC5 PCM1 PIAS1 PIAS4 PPP4C PRC1 PRKCI PRKDC RAD1 RAD51 RAD52 RAD9A RBM14 RBM48 RPA1 RPA3 RPLP1 SDF4 SERTAD3 SLC17A9 STAT3 TLE1 TUBB2A UNC119 UNG UTP14A XPA YWHAE ZBTB14
Entrez ID		983	6118
HPRD ID		00302	01566
Ensembl ID		ENSG00000170312	ENSG00000117748
Uniprot IDs		A0A024QZJ8 B7Z3D6 I6L9I5 P06493	B4DUL2 P15927
PDB IDs		1LC9 4Y72 4YC3 4YC6 5HQ0 5LQF 6GU2 6GU3 6GU4 6GU6 6GU7	1DPU 1L1O 1QUQ 1Z1D 2PI2 2PQA 2Z6K 3KDF 4MQV 4OU0
Enriched GO Terms of Interacting Partners?
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