RPA2 and XPA

Number of citations of the paper that reports this interaction (PubMedID 11081631)
107

Data Source:
HPRD (in vitro)

		RPA2	XPA
Description		replication protein A2	XPA, DNA damage recognition and repair factor
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm DNA Replication Factor A Complex Nuclear Body PML Body Site Of Double-strand Break	Nucleotide-excision Repair Factor 1 Complex Nucleus Nucleoplasm Cytoplasm Intercellular Bridge
	Molecular Function	Damaged DNA Binding Single-stranded DNA Binding Protein Binding Enzyme Binding Protein Phosphatase Binding Ubiquitin Protein Ligase Binding Protein N-terminus Binding G-rich Strand Telomeric DNA Binding	Damaged DNA Binding Protein Binding Protein Domain Specific Binding Protein Homodimerization Activity Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Replication Base-excision Repair Nucleotide-excision Repair Mismatch Repair Regulation Of Double-strand Break Repair Via Homologous Recombination Mitotic G1 DNA Damage Checkpoint Signaling Protein Localization To Chromosome Regulation Of DNA Damage Checkpoint	Nucleotide-excision Repair, DNA Damage Recognition DNA Repair Base-excision Repair UV Protection Response To Auditory Stimulus Nucleotide-excision Repair, DNA Incision Protein Localization To Nucleus UV-damage Excision Repair Nucleotide-excision Repair Involved In Interstrand Cross-link Repair
Pathways		Translesion synthesis by REV1 Recognition of DNA damage by PCNA-containing replication complex Translesion Synthesis by POLH Removal of the Flap Intermediate from the C-strand Activation of ATR in response to replication stress Regulation of HSF1-mediated heat shock response HSF1 activation Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) PCNA-Dependent Long Patch Base Excision Repair Translesion synthesis by POLK Translesion synthesis by POLI Termination of translesion DNA synthesis HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Formation of Incision Complex in GG-NER Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Fanconi Anemia Pathway Regulation of TP53 Activity through Phosphorylation Activation of the pre-replicative complex Removal of the Flap Intermediate G2/M DNA damage checkpoint Meiotic recombination	Formation of Incision Complex in GG-NER Dual Incision in GG-NER Formation of TC-NER Pre-Incision Complex Dual incision in TC-NER
Drugs
Diseases
GWAS		HDL cholesterol levels ( 32203549) Platelet count ( 32888494) Plateletcrit ( 32888494) White blood cell count ( 32888494)	Hypothyroidism ( 27182965) Obesity-related traits ( 23251661) Serum thyroid-stimulating hormone levels ( 24852370) Thyroid cancer (Papillary, radiation-related) ( 20350937)
Interacting Genes		65 interacting genes: ACP5 AKAP9 APP ATM CALCOCO2 CASK CCNC CCNO CDC5L CDK1 CEP126 CFB COPS6 CRMP1 DMRTB1 EEF1A1 EIF4G2 ERCC1 ERCC4 GAPDH GOLM1 HERPUD1 HNRNPUL1 HUS1 LNX2 LRIF1 MARK2 MCM2 MCM5 MED1 MED31 MEN1 NDEL1 ORC1 ORC2 ORC4 ORC5 PCM1 PIAS1 PIAS4 PPP4C PRC1 PRKCI PRKDC RAD1 RAD51 RAD52 RAD9A RBM14 RBM48 RPA1 RPA3 RPLP1 SDF4 SERTAD3 SLC17A9 STAT3 TLE1 TUBB2A UNC119 UNG UTP14A XPA YWHAE ZBTB14	52 interacting genes: AP2M1 ARID3A ATM ATR AURKA BMPR1A BUB1 DDB1 DDB2 DLC1 DVL3 ERCC1 ERCC4 ERCC6 FBXW7 GPN1 GTF2E2 GTF2H1 HERC2 MEOX2 MLH1 MLH3 MSH2 MSH3 MUTYH NDEL1 NRAS PCNA PDGFRL PICK1 PMS2 POLR1C PRDM16 PRKDC PSMB1 RASSF1 RB1 RHOU RPA1 RPA2 RPA4 SKIL SMAD2 SNPH SRC STK11 TBC1D7 TRIM27 VPS26C XAB2 XPC ZNF655
Entrez ID		6118	7507
HPRD ID		01566	02045
Ensembl ID		ENSG00000117748	ENSG00000136936
Uniprot IDs		B4DUL2 P15927	P23025
PDB IDs		1DPU 1L1O 1QUQ 1Z1D 2PI2 2PQA 2Z6K 3KDF 4MQV 4OU0	1D4U 1XPA 2JNW 6J44 6LAE 6RO4
Enriched GO Terms of Interacting Partners?
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